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Sensors and actuators. B, Chemical v.259, 2018년, pp.233 - 240   SCI SCIE SCOPUS
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A novel “turn-on” fluorescent probe with a large stokes shift for homocysteine and cysteine: Performance in living cells and zebrafish

Song, Haohan (Institute of Environmental and Analytical Sciences, Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China ) ; Zhang, Junli (Institute of Plant Stress Biology, State Key Laboratory of Cotton Biology, Department of Biology, Henan University, Kaifeng 475004, China ) ; Wang, Xiao (Institute of Environmental and Analytical Sciences, Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China ) ; Zhou, Yanmei (Institute of Environmental and Analytical Sciences, Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China ) ; Xu, Chenggong (Institute of Environmental and Analytical Sciences, Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemis ) ; Pang, Xiaobin ; Peng, Xiaojun ;
  • 초록  

    Abstract Carbazole-based fluorescent probes have a significant edge on structure and optical properties, but stokes shift of them were mostly less than 100 nm. In this work, a novel carbazole-based fluorescent probe, which featured with a large stokes shift (128 nm), was used to effectively detect homocysteine (Hcy) and cysteine (Cys). This probe revealed obvious color variation and a “turn-on” alteration of fluoresence toward Hcy and Cys. Furthermore, the probe works under physiological conditions and can image thiol in living cells as well as zebrafish because of its wonderful cell permeability. Notably, it provides a possibility to detect endogenous bio-thiols quantitatively in living cells. Highlights A novel colorimetric and turn-on fluorescent probe for Hcy and Cys was synthesized. The probe shows a large stokes shift (128 nm). The probe can be used for imaging in living cells and zebrafish. The probe provides a possibility to detect endogenous bio-thiols quantitatively. Graphical abstract [DISPLAY OMISSION]


  • 주제어

    Thiol probe .   “Turn-on” fluorescence .   Large stokes shift .   Cell imaging .   Zebrafish imaging.  

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