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Sensors and actuators. B, Chemical v.259, 2018년, pp.1099 - 1107   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Numerical prototyping of lateral flow biosensors

Schaumburg, Federico (Instituto de Desarrollo Tecnológico para la Industria Química (INTEC, UNL–CONICET), Colectora RN 168 Km 472, S3000GLN Santa Fe, Argentina ) ; Kler, Pablo A. (Centro de Investigación de Métodos Computacionales (CIMEC, UNL–CONICET), Colectora RN 168 Km 472, S3000GLN Santa Fe, Argentina ) ; Berli, Claudio L.A. (Instituto de Desarrollo Tecnológico para la Industria Química (INTEC, UNL–CONICET), Colectora RN 168 Km 472, S3000GLN Santa Fe, Argentina ) ;
  • 초록  

    Abstract Lateral flow biosensors (LFB) have become a hot topic in the scientific literature in association with the rapid growing of paper-based microfluidics. Improving the existing LFB technology is a challenging task that demands large experimental efforts. Thus computer simulations are practical tools to assist the development of novel devices, since running virtual experiments considerably reduces costs and time in the path from design to real LFB prototypes. We present a computational tool for 3D numerical prototyping of LFB, which accounts for the fluid dynamics (including capillary-driven flow) in the heterogeneous porous materials, the transport of reactive components, and all the biochemical reactions involved. Mathematical modeling was carried out in the framework of continuum transport phenomena, and numerical calculations were implemented by using the finite element method. This numerical prototyping allows developers to explore arbitrary architectures, materials, and assay formats, which is demonstrated here by discussing different real-world examples. The advantages of the proposed numerical model are also discussed in relation to up-to-date reported methods. Highlights A novel complete numerical prototyping of lateral flow biosensors is presented. Full transport problem in 3D paper-based microfluidic devices is considered. The model enables LFB design with different geometries and assay formats. Better binding efficiency, shorter assay times, or improved LODs are readily explored.


  • 주제어

    Numerical prototype .   Lateral flow biosensor .   Lateral flow immunoassay .   Paper-based microfluidics.  

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