Preparation of bright fluorescent polydopamine-glutathione nanoparticles and their application for sensing of hydrogen peroxide and glucose
Abstract A novel water-soluble fluorescent polydopamine derivative, polydopamine-glutathione nanoparticles (PDA-G (-S-)NPs), was synthesized by the Michael addition reaction between dopamine (DA) and reduced glutathione (GSH). Compared to a direct polymerization of dopamine, the as-prepared PDA-G (-S-)NPs have stronger fluorescence emission intensity. Also, the synthesis does not need any hazardous organic solvents and the process is simple. Additionally, the roles of GSH and hydrogen peroxide (H 2 O 2 ) in enhancing the fluorescence intensity are discussed in detail. The thioether in PDA-G (-S-)NPs is easily oxidized by hydrogen peroxide to sulfoxide and sulfone groups, accompanied by a decrease in fluorescence intensity. Therefore, the PDA-G (-S-)NPs can be applied to construct a fluorescent sensor for the sensitive detection of hydrogen peroxide. Based on the transformation of glucose into gluconic acid and H 2 O 2 in the presence of glucose oxidase, the PDA-G (-S-)NPs system was further utilized to sensing glucose. The linear ranges and detection limits of hydrogen peroxide and glucose are (0.5–6 μM, 2–130 μM) and (0.15 μM, 0.6 μM), respectively. Highlights GSH was used as a surface modifier to enhance the fluorescence of polydopamine. The synthesis of the nanoparticles is simple without involving in organic solvents. A rapid fluorescent sensor for hydrogen peroxide and glucose was obtained. The probe has a good practicability for practical sample detection. Graphical abstract [DISPLAY OMISSION]
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