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Hematological parameters and red blood cell morphological abnormality of Glucose-6-Phosphate dehydrogenase deficiency co-inherited with thalassemia

Pengon, Jutharat (Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand ) ; Svasti, Saovaros (Thalassemia Research Centre, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand ) ; Kamchonwongpaisan, Sumalee (Medical Molecular Biology Research Unit, BIOTEC, National Science and Technology Development Agency, Pathum Thani, Thailand ) ; Vattanaviboon, Phantip (Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand ) ;
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    Abstract Objective/Background Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and thalassemia are genetically independent hemolytic disorders. Co-inheritance of both disorders may affect red blood cell pathology to a greater extent than normally seen in either disorder alone. This study determines the prevalence and evaluates hematological changes of G-6-PD deficiency and thalassemia co-inheritance. Methods G-6-PD deficiency was screened from 200 male thalassemia blood samples using a fluorescent spot test. Hematological parameters and red blood cell morphology were evaluated among G-6-PD deficiency/thalassemia co-inheritance, G-6-PD deficiency alone, thalassemia alone, and normal individuals. Results G-6-PD deficiency was detected together with hemoglobin (Hb) E heterozygote, Hb E homozygote, β-thalassemia trait, and β-thalassemia/Hb E, α-thalassemia-2 trait, and Hb H disease. Hb level, hematocrit, mean cell volume, and mean cell Hb of G-6-PD deficiency co-inherited with asymptomatic thalassemia carriers show significantly lower mean values compared to carriers with only the same thalassemia genotypes. Higher mean red blood cell distribution width was observed in G-6-PD deficiency co-inherited with Hb E heterozygote, as with numbers of hemighost cells in G-6-PD deficiency/thalassemia co-inheritance compared to those with either disorder. Apart from Hb level, hematological parameters of co-inheritance disorders were not different from individuals with a single thalassemia disease. Conclusion G-6-PD deficiency co-inherited with thalassemia in males was present in 10% of the participants, resulting in worsening of red blood cell pathology compared with inheritance of thalassemia alone.


  • 주제어

    G-6-PD deficiency .   Red blood cell morphology .   Red blood cell parameters .   Thalassemia.  

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