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Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases v.60, 2018년, pp.117 - 125   SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Up-regulated Th17 cell function is associated with increased peptic ulcer disease in Helicobacter pylori-infection

Bagheri, Nader (Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran ) ; Razavi, Alireza (Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran ) ; Pourgheysari, Batoul (Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran ) ; Azadegan-Dehkordi, Fatemeh (Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran ) ; Rahimian, Ghorbanali (Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran ) ; Pirayesh, Ashkan (Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran ) ; Shafigh, Mohammedhadi (Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran ) ; Rafieian-Kopaei, Mahmoud (Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran ) ; Fereidani, Rana (Department of Pathology, Shahrekord Un ) ; Tahmasbi, Kamran ; Shirzad, Hedayatollah ;
  • 초록  

    Abstract Background During Helicobacter pylori ( H. pylori ) infection CD4 + T cells in the gastric lamina propria are hyporesponsive and polarized by Th1/Th17 cell responses controlled by Treg cells. The objective of this study was to determine the number of Th17 cells in gastric mucosa of patients with gastritis and peptic ulcer and determined the relationship between main virulence factor of H. pylori and Th17 cells. Methods and materials A total of 89 H. pylori -infected gastritis patients, 63 H. pylori -infected peptic ulcer patients and 48 H. pylori -negative non-ulcer dysplasia patients were enrolled in this study. The number of Th17 was determined by immunohistochemistry. IL-8 and IL-17A expressions were determined by real-time polymerase chain reaction (qPCR). Also, the grade of chronic and active inflammation was investigated for involvement according to the density of neutrophils and mononuclear in gastric mucosal crypts, from one to all crypts. Results The number of Th17 cells and the expression of IL-8 and IL-17A in infected patients were significantly higher than uninfected subjects. The number of Th17 cells and the expression of IL-8 and IL-17A in infected patients with peptic ulcer were significantly higher than patients with gastritis. Additionally, the numbers of Th17 cells as well as the expression of IL-8 and IL-17A were positively correlated with the degree of H. pylori density in infected patients with peptic ulcer, while this correlation was negative in infected patients with gastritis. The numbers of Th17 cells as well as the expression of IL-8 and IL-17A were positively correlated with the degree of chronic inflammation. Conclusion The predominant Th17 cell responses may play a role in the pathogenesis of peptic ulcers disease in infected patients. Highlights The number of Th17 cells in infected patients had a significantly higher than uninfected. The number of Th17 cells was dependent on the oipA, but it was independent on cagA. The number of Th17 cells in infected patients with peptic ulcer was significantly higher. The numbers of Th17 cells was positively correlated with the degree of chronic inflammation. The numbers of Th17 cells was positively correlated with H. pylori density in patients with PUD.


  • 주제어

    Helicobacter pylori .   Th17 .   Gastritis .   Peptic ulcer disease .   Virulence factor.  

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