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Tetrahedron v.74 no.16, 2018년, pp.2100 - 2106   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Streptopyrazinones A−D, rare metabolites from marine-derived Streptomyces sp. ZZ446

Chen, Mengxuan (Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, PR China ) ; Chai, Weiyun (Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, PR China ) ; Zhu, Rongyao (College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China ) ; Song, Tengfei (Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, PR China ) ; Zhang, Zhizhen (Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, PR China ) ; Lian, Xiao-Yuan (College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China ) ;
  • 초록  

    Abstract Secondary metabolites from marine-associated actinomycetes are important source for the discovery of novel bioactive compounds. In this study, an actinomycete Streptomyces sp. ZZ446 was isolated from coastal soils and different media were used to culture this isolated marine actinomycete. It has been found that this actinomycete in the liquid medium of 2216 E with sea salt produced five new compounds of streptopyrazinones A−D ( 1 – 4 ) and N -acetyl- L -isoleucine- L -leucinamide ( 5 ) as well as six known diketopiperazines ( 6 – 11 ) and one alkaloid ( 12 ). Structures of the new compounds were determined by extensive NMR analyses, HRESIMS data, electronic circular dichroism (ECD) calculation, chemical degradation, Marfey's method, and X-ray diffraction analysis. This type of streptopyrazinones A−D ( 1 – 4 ) is rarely found in the natural resources. New compounds 1 – 5 showed activity in inhibiting the growth of Candida albicans and methicillin-resistant Staphylococcus aureus . Highlights Five new compounds were isolated from marine-associated Streptomyces sp. The discovery of the new compounds was the result of an OSMAC strategy. Streptopyrazinones A−D are rare compounds found in the natural resources. New compounds showed antimicrobial activity. Graphical abstract [DISPLAY OMISSION]


  • 주제어

    Streptomyces sp.   ZZ446 .   Marine actinomycete .   Streptopyrazinones .   Candida albicans .   Methicillin-resistant Staphylococcus aureus.  

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