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Journal of the mechanical behavior of biomedical materials v.81, 2018년, pp.39 - 45   SCIE
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The impact of shape memory test on degradation profile of a bioresorbable polymer

Musioł, Marta (Polish Academy of Sciences, Centre of Polymer and Carbon Materials, 34, M. Curie-Skłodowska St., 41-819 Zabrze, Poland ) ; Jurczyk, Sebastian (Institute for Engineering of Polymer Materials and Dyes, Paint and Plastics Department in Gliwice, 50A Chorzowska St., 44-100 Gliwice, Poland ) ; Kwiecień, Michał (Polish Academy of Sciences, Centre of Polymer and Carbon Materials, 34, M. Curie-Skłodowska St., 41-819 Zabrze, Poland ) ; Smola-Dmochowska, Anna (Polish Academy of Sciences, Centre of Polymer and Carbon Materials, 34, M. Curie-Skłodowska St., 41-819 Zabrze, Poland ) ; Domański, Marian (Polish Academy of Sciences, Centre of Polymer and Carbon Materials, 34, M. Curie-Skłodowska St., 41-819 Zabrze, Poland ) ; Janeczek, Henryk (Polish Academy of Sciences, Centre of Polymer and Carbon Materials, 34, M. Curie-Skłodowska St., 41-819 Zabrze, Poland ) ; Włodarczyk, Jakub (Polish Academy of Sciences, Centre of Polymer and Carbon Materials, 34, M. Curie-Skłodowska St., 41-819 Zabrze, Poland ) ; Klim, Magdalena (Polish Academy of Sciences, Centre of Polymer and Carbon Materials, 34, M. Curie-Skłodowska St., 41-819 Zabrze, Pola ) ; Rydz, Joanna ; Kawalec, Michał ; Sobota, Michał ;
  • 초록  

    Abstract The semicrystalline poly(L-lactide) (PLLA) belongs to the materials with shape memory effect (SME) and as a bioresorbable and biocompatible polymer it have found many applications in medical and pharmaceutical field. Assessment of the SME impact on the polymer degradation profile plays crucial role in applications such as drug release systems or in regenerative medicine. Herein, the results of in vitro degradation studies of PLLA samples after SME full test cycle are presented. The samples were loaded and deformed in two manners: progressive and non-progressive. The performed experiments illustrate also influence of the material mechanical damages, caused e.g. during incorrect implantation of PLLA product, on hydrolytic degradation profile. Apparently, degradation profiles are significantly different for the material which was not subjected to the deformation and the deformed ones. The materials after deformation of 50% (in SME cycle) was characterized by non-reversible morphology changes. The effect was observed in deformed samples during the SME test which were carried out ten times.


  • 주제어

    PLLA .   Polylactide .   SMP .   Drug release .   Shape memory effect .   SME.  

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