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European journal of cancer v.93, 2018년, pp.99 - 107   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Randomised phase III trial of concurrent chemoradiotherapy with extended nodal irradiation and erlotinib in patients with inoperable oesophageal squamous cell cancer

Wu, Shi-Xiu    (Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou, China   ); Wang, LV-Hua    (Department of Radiation Oncology, Cancer Hospital Chinese Academy of Medical Sciences, Beijing, China   ); Luo, Hong-Lei    (Department of Radiation Oncology, No.1 People's Hospital of Huaian, Huaian, China   ); Xie, Cong-Ying    (Department of Radiation Oncology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China   ); Zhang, Xue-Bang    (Department of Radiation Oncology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China   ); Hu, Wei    (Department of Radiation Oncology, Taizhou Hospital of Zhejiang Province, Linhai, China   ); Zheng, An-Ping    (Department of Radiation Oncology, Anyang Cancer Hospital, Anyang, China   ); Li, Duo-Jie    (Department of Radiation Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China   ); Zhang, Hong-Yan    (Department of Radiation Oncology, Anhui Provincial Hospital, Anhui, China   ); Xie, Cong-Hua    (Department of Radiation Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China   ); Lian, Xi-Long    (Department of Radiation Oncology, Kaohsiung Medical University Hospital Cancer Cen  ); Du, De-Xi   Chen, Ming   Bian, Xiu-Hua   Tan, Bang-Xian   Jiang, Hao   Zhang, Hong-Bo   Wang, Jian-Hua   Jing, Zhao   Xia, Bing   Zhang, Ni   Zhang, Ping   Li, Wen-Feng   Zhao, Fu-Jun   Tian, Zhi-Feng   Liu, Hui   Huang, Ke-Wei   Hu, Jin   Xie, Rui-Fei   Du, Lin   Li, Gang  
  • 초록  

    Abstract Background This randomised phase III study was conducted to investigate the efficacy of extended nodal irradiation (ENI) and/or erlotinib in inoperable oesophageal squamous cell cancer (ESCC). Patients and methods Patients with histologically confirmed locally advanced ESCC or medically inoperable disease were randomly assigned (ratio 1:1:1:1) to one of four treatment groups: group A, radiotherapy adoption of ENI with two cycles of concurrent TP chemotherapy (paclitaxel 135 mg/m 2 day 1 and cisplatin 20 mg/m 2 days 1–3, every 4 weeks) plus erlotinib (150 mg per day during chemoradiotherapy); group B, radiotherapy adoption of ENI with two cycles of concurrent TP; group C, radiotherapy adoption of conventional field irradiation (CFI) with two cycles of concurrent TP plus erlotinib; group D, radiotherapy adoption of CFI with two cycles of concurrent TP. Results A total of 352 patients (88 assigned to each treatment group) were enrolled. The 2-year overall survival rates of group A, B, C and D were 57.8%, 49.9%, 44.9% and 38.7%, respectively ( P = 0.015). Group A significantly improved 2-year overall survival compared with group D. The ENI significantly improved overall survival in patients with inoperable ESCC ( P = 0.014). The addition of erlotinib significantly decreased loco-regional recurrence ( P = 0.042). Aside from rash and radiation oesophagitis, the incidence of grade 3 or greater toxicities did not differ among 4 groups. Conclusion Chemoradiotherapy with ENI and erlotinib might represent a substantial improvement on the standard of care for inoperable ESCC. ENI alone should be adopted in concurrent chemoradiotherapy for ESCC patients. Highlights Chemotherapy with extended nodal irradiation and erlotinib improve survival for inoperable oesophageal squamous cell cancer. Chemoradiotherapy with ENI alone can significantly improve 2-year overall survival to 54.0% and reduce 31.2% risk of death. ENI alone should be adopted in concurrent chemoradiotherapy for inoperable ESCC.


  • 주제어

    Oesophageal squamous cell cancer .   Extended nodal irradiation .   Erlotinib.  

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