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Computers in biology and medicine v.95, 2018년, pp.34 - 42   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Discrete multi-physics simulations of diffusive and convective mass transfer in boundary layers containing motile cilia in lungs

Ariane, Mostapha (School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom ) ; Kassinos, Stavros (Department of Mechanical and Manufacturing Engineering, University of Cyprus, 1678, Nicosia, Cyprus ) ; Velaga, Sitaram (Pharmaceutical Research Group, Division of Medical Science, Department of Health Science, Luleå ) ; Alexiadis, Alessio (University of Technology, 971 87, Luleå, Sweden ) ;
  • 초록  

    Abstract In this paper, the mass transfer coefficient (permeability) of boundary layers containing motile cilia is investigated by means of discrete multi-physics. The idea is to understand the main mechanisms of mass transport occurring in a ciliated-layer; one specific application being inhaled drugs in the respiratory epithelium. The effect of drug diffusivity, cilia beat frequency and cilia flexibility is studied. Our results show the existence of three mass transfer regimes. A low frequency regime, which we called shielding regime, where the presence of the cilia hinders mass transport; an intermediate frequency regime, which we have called diffusive regime, where diffusion is the controlling mechanism; and a high frequency regime, which we have called convective regime, where the degree of bending of the cilia seems to be the most important factor controlling mass transfer in the ciliated-layer. Since the flexibility of the cilia and the frequency of the beat changes with age and health conditions, the knowledge of these three regimes allows prediction of how mass transfer varies with these factors. Highlights The Discrete Multi-Physics is applied to boundary layers containing motile cilia (mass transfer). The effect of drug diffusivity, cilia beat frequency and cilia flexibility is investigated. The results show the existence of three mass transfer regimes: Shielding regime, diffusive regime and convective regime.


  • 주제어

    Discrete multi-physics .   Smoothed particle hydrodynamics .   Mass-spring model .   Cilia .   Diffusivity .   Mass transfer.  

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