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Anaerobe v.51, 2018년, pp.73 - 77   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Toxin profile of fecal Clostridium perfringens strains isolated from children with autism spectrum disorders

Góra, Bartłomiej    (Department of Medical Microbiology School of Medicine in Katowice, Medical University of Silesia, Poland   ); Gofron, Zygmunt    (Department of Medical Microbiology School of Medicine in Katowice, Medical University of Silesia, Poland   ); Grosiak, Magdalena    (Department of Medical Microbiology School of Medicine in Katowice, Medical University of Silesia, Poland   ); Aptekorz, Małgorzata    (Department of Medical Microbiology School of Medicine in Katowice, Medical University of Silesia, Poland   ); Kazek, Beata    (Department of Neuropediatrics School of Medicine in Katowice, Medical University of Silesia, Poland   ); Kocelak, Piotr    (Department of Pathophysiology School of Medicine in Katowice, Medical University of Silesia, Poland   ); Radosz-Komoniewska, Halina    (Department of Medical Microbiology School of Medicine in Katowice, Medical University of Silesia, Poland   ); Chudek, Jerzy    (Department of Pathophysiology School of Medicine in Katowice, Medical University of Silesia, Poland   ); Martirosian, Gayane    (Department of Medical Microbiology School of Medicine in Katowice, Medical University of Silesia, Poland  );
  • 초록  

    Abstract Infectious factors are taken into consideration in pathophysiology of autism spectrum disorders (ASD). ASD patients often suffer from gastrointestinal disorders. The intestinal microbiota of autistic patients significantly differs from that in healthy individuals. The aim of the study was to compare the profile of toxins produced by C. perfringens strains isolated from feces of children with ASD, with healthy individuals and obese subjects. This study included 111 strains of C. perfringens : 49 isolates from 29 children with ASD, 30 - from 17 healthy individuals and 32 - from 24 young obese subjects. Alpha, beta, beta2, epsilon, iota and enterotoxin genes were detected using appropriate PCRs. The alpha toxin gene ( cpa ) was present in all 111 examined strains (100%). The beta2 gene ( cpb2 ) was detected in 45/49 strains (91.8%) isolated from children with ASD, 17/30 (56.7%) isolates from healthy subjects, and 12 of 32 (37.5%) isolates from obese subjects. C. perfringens strains with cpb2 gene were detected in 27/29 ASD patients (93.1%), 10/17 healthy subjects (58.8%) and 11/24 (45.8%) obese subjects. Beta2 toxin encoding cpb2 gene was significantly more common in strains isolated from ASD patients, with no significant difference between control subjects regardless of diet. Further research to explain observed phenomena and pathomechanism of beta2 toxin is required. Highlights ASD patients possess beta2 toxin gene-positive C.perfringens strains significantly more often than healthy and obese subjects. There were no changes in prevalence of such strains in healthy normal weight and obese subjects (unaffected by diet). Further studies are required to explain beta2 toxin activity and possible neurotoxic mechanism.


  • 주제어

    Clostridium perfringens .   Beta2 toxin gene .   Autism spectrum disorders (ASD).  

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