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Nature communications v.9 no.1, 2018년, pp.2145 - 2145   SCI SCIE
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Protein disorder–order interplay to guide the growth of hierarchical mineralized structures

Elsharkawy, Sherif    (Institute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK   ); Al-Jawad, Maisoon    (School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK   ); Pantano, Maria F.    (Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4NS, UK   ); Tejeda-Montes, Esther    (Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4NS, UK   ); Mehta, Khushbu    (Materials Research Institute, Queen Mary University of London, London, E1 4NS, UK   ); Jamal, Hasan    (Laboratory of Bio-Inspired and Graphene Nanomechanics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, 38123, Trento, Italy   ); Agarwal, Shweta    (School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK   ); Shuturminska, Kseniya    (School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK   ); Rice, Alistair    (School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK   ); Tarakina, Nadezda V.    (Departme  ); Wilson, Rory M.   Bushby, Andy J.   Alonso, Matilde   Rodriguez-Cabello, Jose C.   Barbieri, Ettore   del Río Hernández, Armando   Stevens, Molly M.   Pugno, Nicola M.   Anderson, Paul   Mata, Alvaro  
  • 초록  

    A major goal in materials science is to develop bioinspired functional materials based on the precise control of molecular building blocks across length scales. Here we report a protein-mediated mineralization process that takes advantage of disorder–order interplay using elastin-like recombinamers to program organic–inorganic interactions into hierarchically ordered mineralized structures. The materials comprise elongated apatite nanocrystals that are aligned and organized into microscopic prisms, which grow together into spherulite-like structures hundreds of micrometers in diameter that come together to fill macroscopic areas. The structures can be grown over large uneven surfaces and native tissues as acid-resistant membranes or coatings with tuneable hierarchy, stiffness, and hardness. Our study represents a potential strategy for complex materials design that may open opportunities for hard tissue repair and provide insights into the role of molecular disorder in human physiology and pathology.


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