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Angewandte Chemie. international edition v.57 no.27, 2018년, pp.8120 - 8124   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Self‐Reporting Inhibitors: A Single Crystallization Process To Obtain Two Optically Pure Enantiomers

Ye, Xichong (Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China ) ; Cui, Jiaxi (INM—, Leibniz Institute for New Materials, Campus D22, 66123, Saarbrucken, Germany ) ; Li, Bowen (Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China ) ; Li, Na (Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China ) ; Zhang, Jie (Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of ) ; Wan, Xinhua ;
  • 초록  

    Abstract Collection of two optically pure enantiomers in a single crystallization process can significantly increase the chiral separation efficiency but this is difficult to realize. Now a self‐reporting strategy is presented for visualizing the crystallization process by a dyed self‐assembled inhibitor made from the copolymers with tri(ethylene glycol)‐grafting polymethylsiloxane as the main chain and poly(N 6 ‐methacryloyl‐ l ‐lysine) as side chains. When applied with seeds together for the fractional crystallization of conglomerates, the inhibitors can label the formation of the secondary crystals and guide the complete separation process of two enantiomers with colorless crystals as the first product and red crystals as the second. This method leads to high optical purity of d / l ‐Asn⋅H 2 O (99.9 % ee for d ‐crystals and 99.5 % for l ‐crystals) in a single crystallization process. It requires a small amount of additives and shows excellent recyclability.


  • 주제어

    chiral resolution .   inhibitors .   polymers .   self-assembly .   self-reporting.  

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