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Maintenance of redox balance by antioxidants in hemolymph of the greater wax moth Galleria mellonella larvae during encapsulation response

Grizanova, Ekaterina V. (Novosibirsk State Agrarian University, Novosibirsk, Russia ) ; Semenova, Alexandra D. (Institute of Chemical Kinetics and Combustion, Russian Academy of Sciences, Siberian Branch, Novosibirsk, Russia ) ; Komarov, Denis A. (Institute of Chemical Kinetics and Combustion, Russian Academy of Sciences, Siberian Branch, Novosibirsk, Russia ) ; Chertkova, Ekaterina A. (Institute of Systematic and Ecology of Animals, Russian Academy of Sciences, Siberian Branch, Novosibirsk, Russia ) ; Slepneva, Irina A. (Institute of Chemical Kinetics and Combustion, Russian Academy of Sciences, Siberian Branch, Novosibirsk, Russia ) ; Dubovskiy, Ivan M. (Novosibirsk State Agrarian University, Novosibirsk, Russia ) ;
  • 초록  

    Abstract The lipid peroxidation process in hemocytes, activities of phenoloxidase and key enzymatic antioxidants (superoxide dismutase, glutathione‐S‐transferase, catalase) and nonenzymatic antioxidants (thiols, ascorbate) in hemolymph of the greater wax moth Galleria mellonella L. (Lepidoptera: Pyralidae) were studied during the encapsulation process of nylon implants. It has been established that as soon as 15 min after piercing a cuticle with the implant, a capsule is formed on its surface. Active melanization of the capsule has been shown to last for 4 h. During the first hours after incorporating the implant, an increase in phenoloxidase activity and lipid peroxidation in the insect hemocytes has been revealed. Adhesion and degranulation on the surface of foreign object lead to the depletion of total hemocytes count (THC). Our results indicated that thiols and ascorbate molecules take part in the immediate antioxidant response, during later stages of encapsulation process hemolymph glutathione‐S‐transferase detoxifies and protects insect organism thereby restoring the internal redox balance. We suggest that nonenzymatic and enzymatic antioxidants of hemolymph plasma play a key role in the maintenance of redox balance during encapsulation of foreign targets.


  • 주제어

    antioxidant system .   cellular immune response .   hemocytes .   insect immunity .   MDA .   melanization .   redox balance .   ROS .   wax moth.  

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