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British journal of surgery : BJS v.105 no.9, 2018년, pp.1128 - 1134  

Two‐year results of the randomized clinical trial DILALA comparing laparoscopic lavage with resection as treatment for perforated diverticulitis

Kohl, A. (Centre for Perioperative Optimization, Department of Surgery, Herlev Hospital, Herlev, and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark ) ; Rosenberg, J. (Centre for Perioperative Optimization, Department of Surgery, Herlev Hospital, Herlev, and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark ) ; Bock, D. (Department of Surgery, Institute of Clinical Sciences, Scandinavian Surgical Outcomes Research Group, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden ) ; Bisgaard, T. (GastroUnit, Surgical Division, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark ) ; Skullman, S. (Department of Surgery, Skövde Hospital, Skövde, Sweden ) ; Thornell, A. (Department of Surgery, Institute of Clinical Sciences, Scandinavian Surgical Outcomes Research Group, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital/Öst ) ; Gehrman, J. ; Angenete, E. ; Haglind, E. ;
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    Background Traditionally, perforated diverticulitis with purulent peritonitis was treated with resection and colostomy (Hartmann's procedure), with inherent complications and risk of a permanent stoma. The DILALA (DIverticulitis – LAparoscopic LAvage versus resection (Hartmann's procedure) for acute diverticulitis with peritonitis) and other randomized trials found laparoscopic lavage to be a feasible and safe alternative. The medium‐term follow‐up results of DILALA are reported here. Methods Patients were randomized during surgery after being diagnosed with Hinchey grade III perforated diverticulitis at diagnostic laparoscopy. The primary outcome was the proportion of patients with one or more secondary operations from 0 to 24 months after the index procedure in the laparoscopic lavage versus Hartmann's procedure groups. The trial was registered as ISRCTN82208287. Results Forty‐three patients were randomized to laparoscopic lavage and 40 to Hartmann's procedure. Patients in the lavage group had a 45 per cent reduced risk of undergoing one or more operations within 24 months (relative risk 0·55, 95 per cent c.i. 0·36 to 0·84; P = 0·012) and had fewer operations (ratio 0·51, 95 per cent c.i. 0·31 to 0·87; P = 0·024) compared with those in the Hartmann's group. No difference was found in mean number of readmissions (1·37 versus 1·50; P = 0·221) or mortality between patients randomized to laparoscopic lavage or Hartmann's procedure. Three patients in the lavage group and nine in the Hartmann's group had a colostomy at 24 months. Conclusion Laparoscopic lavage is a better option for perforated diverticulitis with purulent peritonitis than open resection and colostomy.


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