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Biomedical chromatography : BMC v.32 no.8, 2018년, pp.e4250 -   

Inhibitory effects of Danhong Injection and its major constituents on human cytochrome P450 enzymes in vitro

Ye, Lin‐Hu (Department of Pharmacy, The First People's Hospital of Bijie, Bijie, China ) ; Zhao, Xin‐Qian (Department of Pharmacy, The First People's Hospital of Bijie, Bijie, China ) ; Kong, Ling‐Ti (Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China ) ; Wang, Li‐Sha (Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China ) ; Tao, Xue (Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China ) ; Wu, Hui (Department of Pharmacy, The First People's Hospital of Bijie, Bijie, China ) ; He, Mei (Department of Pharmacy, The First People's Hospital of Bijie, Bijie, China ) ; Chang, Qi (Institute of Medicinal Plant Developmen ) ;
  • 초록  

    Abstract Danhong Injection (DHI) as a Chinese patent medicine is mainly used to treat ischemic encephalopathy and coronary heart disease in combination with other chemotherapy. However, the information on DHI's potential drug interactions is limited. The goal of this work was to examine the potential P450‐mediated metabolism drug interaction arising from DHI and its active components. The results showed that DHI inhibited CYP2C19, CYP2D6, CYP3A4, CYP2E1 and CYP2C9 with IC 50 values of 1.26, 1.42, 1.63, 1.10 and 1.67% ( v /v), respectively. Danshensu and rosmarinic acid inhibited CYP2E1 and CYP2C9 with IC 50 values of 36.63 and 75.76 μ m , and 34.42 and 76.89 μ m , respectively. Salvianolic acid A and B inhibited CYP2D6, CYP2E1 and CYP2C9 with IC 50 values of 33.79, 21.64 and 31.94 μ m , and 45.47, 13.52 and 24.15 μ m , respectively. The study provides some useful information for safe and effective use of DHI in clinical practice.


  • 주제어

    cytochrome P450 .   Danhong Injection .   drug interactions .   HPLC–MS/MS .   traditional Chinese medicine.  

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