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Human brain mapping v.39 no.8, 2018년, pp.3143 - 3151  

A more randomly organized grey matter network is associated with deteriorating language and global cognition in individuals with subjective cognitive decline

Verfaillie, Sander C. J. (Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands ) ; Slot, Rosalinde E. R. (Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands ) ; Dicks, Ellen (Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands ) ; Prins, Niels D. (Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands ) ; Overbeek, Jozefien M. (Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands ) ; Teunissen, Charlotte E. (Department of Clinical Chemistry, VU University Medical Center Amsterdam, The Netherlands ) ; Scheltens, Philip (Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands ) ; Barkhof, Frederik (Department o ) ; van der Flier, Wiesje M. ; Tijms, Betty M. ;
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    Abstract Objectives Grey matter network disruptions in Alzheimer's disease (AD) are associated with worse cognitive impairment cross‐sectionally. Our aim was to investigate whether indications of a more random network organization are associated with longitudinal decline in specific cognitive functions in individuals with subjective cognitive decline (SCD). Experimental design : We included 231 individuals with SCD who had annually repeated neuropsychological assessment (3 ± 1 years; n = 646 neuropsychological investigations) available from the Amsterdam Dementia Cohort (54% male, age: 63 ± 9, MMSE: 28 ± 2). Single‐subject grey matter networks were extracted from baseline 3D‐T1 MRI scans and we computed basic network (size, degree, connectivity density) and higher‐order (path length, clustering, betweenness centrality, normalized path length [lambda] and normalized clustering [gamma]) parameters at whole brain and/or regional levels. We tested associations of network parameters with baseline and annual cognition (memory, attention, executive functioning, language composite scores, and global cognition [all domains with MMSE]) using linear mixed models, adjusted for age, sex, education, scanner and total gray matter volume. Principal observations : Lower network size was associated with steeper decline in language (β ± SE = 0.12 ± 0.05, p p Conclusions A more randomly organized grey matter network was associated with a steeper decline of cognitive functioning, possibly indicating the start of cognitive impairment.


  • 주제어

    Alzheimer's disease .   cognition .   connectivity .   graph theory .   grey matter network .   longitudinal .   mild cognitive impairment .   MRI .   subjective cognitive decline.  

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