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Journal of cellular physiology v.233 no.10, 2018년, pp.6603 - 6612  

Long non‐coding RNA (LncRNA) RMST in triple‐negative breast cancer (TNBC): Expression analysis and biological roles research

Wang, Li (Department of Radiation Oncology, Yunnan Cancer Hospital and The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China ) ; Liu, Dequan (Department of Breast Surgery, Yunnan Cancer Hospital and The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China ) ; Wu, Xingrao (Department of Radiation Oncology, Yunnan Cancer Hospital and The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China ) ; Zeng, Yueqin (Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming, Yunnan, China ) ; Li, Lan (Department of Radiation Oncology, Yunnan Cancer Hospital and The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China ) ; Hou, Yu (Department of Radiation Oncology, Yunnan Cancer Hospital and The Third Affiliated Hospital of Kunming Medical University, Kunmi ) ; Li, Wenhui ; Liu, Zhijie ;

  • 초록  

    Microarray showed that lncRNA RMST was differentially expressed in cervical cancer. Further experiments were conducted to detect the expression and biological function of RMST in triple‐negative breast cancer (TNBC). Microarray was used to screen the differentially expressed lncRNAs in TNBC. QRT‐PCR was applied to uncover the expression of RMST in TNBC tissues. The cell viability of RMST‐transfected TNBC cells were probed by CKK‐8 assay and colony formation assay. TUNEL assay was conducted to test the cell apoptosis and FCM assay was exerted to detect the cell cycle. The invasion and migration ability of transfected cells were examined by transwell assay. RMST played its biological function through regulating the mRNA or protein expression in cytoplasm. CCK‐8 and colony formation assay unveiled that RMST could slow down the proliferation of TNBC cells to influence the tumor progression. TUNEL results revealed that RMST could enhance cell apoptosis in TNBC. The cell cycle detected by FCM assay indicated that RMST might induce the block of G0/G1 phase thus inhibiting TNBC cell proliferation. RMST overexpression could also restrain the invasion and migration abilities of TNBC cells. RMST played a role of tumor suppressor in TNBC through inhibiting cell proliferation, invasion and migration, enhancing cell apoptosis, and regulating cell cycle.


  • 주제어

    lncRNA RMST .   TNBC.  

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