본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of cellular physiology v.233 no.10, 2018년, pp.6603 - 6612  

Long non‐coding RNA (LncRNA) RMST in triple‐negative breast cancer (TNBC): Expression analysis and biological roles research

Wang, Li (Department of Radiation Oncology, Yunnan Cancer Hospital and The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China ) ; Liu, Dequan (Department of Breast Surgery, Yunnan Cancer Hospital and The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China ) ; Wu, Xingrao (Department of Radiation Oncology, Yunnan Cancer Hospital and The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China ) ; Zeng, Yueqin (Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming, Yunnan, China ) ; Li, Lan (Department of Radiation Oncology, Yunnan Cancer Hospital and The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China ) ; Hou, Yu (Department of Radiation Oncology, Yunnan Cancer Hospital and The Third Affiliated Hospital of Kunming Medical University, Kunmi ) ; Li, Wenhui ; Liu, Zhijie ;
  • 초록  

    Microarray showed that lncRNA RMST was differentially expressed in cervical cancer. Further experiments were conducted to detect the expression and biological function of RMST in triple‐negative breast cancer (TNBC). Microarray was used to screen the differentially expressed lncRNAs in TNBC. QRT‐PCR was applied to uncover the expression of RMST in TNBC tissues. The cell viability of RMST‐transfected TNBC cells were probed by CKK‐8 assay and colony formation assay. TUNEL assay was conducted to test the cell apoptosis and FCM assay was exerted to detect the cell cycle. The invasion and migration ability of transfected cells were examined by transwell assay. RMST played its biological function through regulating the mRNA or protein expression in cytoplasm. CCK‐8 and colony formation assay unveiled that RMST could slow down the proliferation of TNBC cells to influence the tumor progression. TUNEL results revealed that RMST could enhance cell apoptosis in TNBC. The cell cycle detected by FCM assay indicated that RMST might induce the block of G0/G1 phase thus inhibiting TNBC cell proliferation. RMST overexpression could also restrain the invasion and migration abilities of TNBC cells. RMST played a role of tumor suppressor in TNBC through inhibiting cell proliferation, invasion and migration, enhancing cell apoptosis, and regulating cell cycle.


  • 주제어

    lncRNA RMST .   TNBC.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기