본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of cellular physiology v.233 no.10, 2018년, pp.6951 - 6964  

Anionic nanoliposomes reduced atherosclerosis progression in Low Density Lipoprotein Receptor (LDLR) deficient mice fed a high fat diet

Krishna, Smriti M.    (Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australi  ); Moxon, Joseph V.    (Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australi  ); Jose, Roby J.    (Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australi  ); Li, Jiaze    (Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australi  ); Sahebkar, Amirhossein    (Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Ira  ); Jaafari, Mahmoud R.    (Nanotechnology Research Centre, Pharmaceutical Technology Institute, M  ); Hatamipour, Mahdi   Liu, Dawie   Golledge, Jonathan  
  • 초록  

    Atherosclerosis is a systemic disease characterized by the deposition of cholesterol and inflammatory cells within the arterial wall. Removal of cholesterol from the vessel wall may have an impact on the size and composition of atherosclerotic lesions. Anionic phospholipids or liposome vesicles composed of a lipid bilayer such as nanoliposomes have been suggested as treatments for dyslipidemia. In this study, we investigated the effect of anionic nanoliposomes on atherosclerosis in a mouse model. Low‐density lipoprotein receptor knockout mice ( Ldlr –/– ) were fed with an atherosclerosis promoting high fat and cholesterol (HFC) diet for 12 weeks. Anionic nanoliposomes including hydrogenated soy phosphatidylcholine (HSPC) and distearoyl phosphatidylglycerol (DSPG) (molar ratio: 1:3) were injected intravenously into HFC‐fed Ldlr −/− mice once a week for 4 weeks. Mice receiving nanoliposomes had significantly reduced atherosclerosis within the aortic arch as assessed by Sudan IV staining area ( p = 0.007 ), and reduced intima/media ratio ( p = 0.030 ) and greater collagen deposition within atherosclerosis plaques within the brachiocephalic artery ( p = 0.007 ), compared to control mice. Administration of nanoliposomes enhanced markers of reverse cholesterol transport (RCT) and increased markers of plaque stability in HFC‐fed Ldlr −/ − mice. Reduced cholesterol accumulation was observed in the liver along with the up‐regulation of the major genes involved in the efflux of cholesterol such as hepatic ATP‐binding cassette transporters (ABC) including Abc‐a1 , Abc‐g1 , Abc‐g5 , and Abc‐g8 , Scavenger receptor class B, member 1 ( Scarb1 ), and Liver X receptor alpha ( Lxr )‐ α . Lecithin Cholesterol Acyltransferase activity within the plasma was also increased in mice receiving nanoliposomes. Anionic nanoliposome administration reduced atherosclerosis in HFC‐fed Ldlr −/− mice by promoting RCT and upregulating the ABC‐A1/ABC‐G1 pathway.


  • 주제어

    anionic nanoliposome .   atherosclerosis .   ATP‐binding cassette transporters .   Low Density Lipoprotein Receptor (LDLR) deficient mice .   reverse cholesterol transport.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기