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Journal of cellular physiology v.233 no.10, 2018년, pp.6344 - 6351  

Protective effect of miR378* on doxorubicin‐induced cardiomyocyte injury via calumenin

Wang, Yu (Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China ) ; Cui, Xiaoxue (Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China ) ; Wang, Yilin (Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China ) ; Fu, Yao (Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China ) ; Guo, Xin (Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China ) ; Long, Jie (Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China ) ; Wei, Chengxi (Medicinal Chemistry and Pharmacology Institute, Inner M ) ; Zhao, Ming ;
  • 초록  

    Doxorubicin (Dox) is a highly effective antitumor antibiotic, however myocardial toxicity severely limits its use clinically. The pathogenesis of doxorubicin‐induced cardiomyopathy is unclear. In Dox cardiomyopathy mice, there is a decline in cardiac function, a change in myocardial pathology and a reduction in miR378* expression. Expression changes in calumenin, an endoplasmic reticulum stress (ERS) chaperone protein and pathway factor, as well as apoptosis, were observed in cardiomyocytes after doxorubicin‐induced injury. However, miR378* increased calumenin expression, eased ERS, and reduced cardiomyocyte apoptosis, while, silencing miR378* reduced calumenin expression, aggravated ERS, and increased cardiomyocyte apoptosis. The above results indicate that miR378* alleviates ERS and inhibits the activation of the ERS‐mediated apoptosis signaling pathway in cardiomyocytes via regulating calumenin expression, thereby reducing cardiomyocyte apoptosis after doxorubicin‐induced injury. Increasing miR378* expression may be a new way to improve cardiac function and quality of life in patients with Dox cardiomyopathy.


  • 주제어

    apoptosis .   calumenin .   doxorubicin .   ERS .   miR378*.  

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