본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of cellular physiology v.233 no.10, 2018년, pp.6975 - 6985  

NOTCH4 regulates colorectal cancer proliferation, invasiveness, and determines clinical outcome of patients

Zhang, Zixi    (Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Chin  ); Bu, Xin    (State Key Laboratory of Cancer Biology and Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, Chin  ); Yang, Jingyi    (Information Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Chin  ); Zhu, Shaojun    (Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, Chin  ); He, Shuixiang    (Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Chin  ); Zheng, Jianyong    (Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, Chin  ); Wang, Weizhong    (Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Disea  ); Chu, Dake  

  • 초록  

    Notch signal has complex roles in human malignancies, which might be attributed to the diversity of Notch receptors. Here, we set out to identify the association of NOTCH4 with colorectal cancer (CRC). In the hospital‐based study cohort, we investigated NOTCH4 mRNA levels in primary CRC, as well as its association with clinicopathologic characteristics. Besides, NOTCH4 cDNA and siRNA was transfected into colorectal cancer cell line to elucidate its impact on tumor cell proliferation and migration. Results revealed a statistically significant lower expression of NOTCH4 mRNA in tumor specimens compared with that in control. NOTCH4 level in CRC was found to be related to tumor differentiation, invasion, and node metastasis. Moreover, it was demonstrated that NOTCH4 mRNA level could be an independent prognostic factor for both disease‐free and overall survival of CRC patients. Overexpression of NOTCH4 in CRC cell lines suppressed tumor cell proliferation, migration, and invasion, while induced apoptosis. In the opposite, the malignant behavior of CRC cells was enhanced by NOTCH4 knockdown. These results demonstrated for the first time that NOTCH4 expression was decreased in CRC, which could determine tumor proliferation, relapse, and prognosis.


  • 주제어

    colorectal cancer .   NOTCH4 .   prognosis .   proliferation .   relapse.  

 활용도 분석

  • 상세보기

    amChart 영역

  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기