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Journal of medical virology v.90 no.9, 2018년, pp.1444 - 1452  

Molecular detection and phylogenetic analysis of human parechovirus in individuals with acute diarrhea and healthy controls in Guangzhou, China

Chen, Xuejiao    (Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Chin  ); Shi, Tingli    (Department of Hospital Infection Management, The Third People's Hospital of Hainan Province, Sanya, Chin  ); Huang, Jianhua    (Public Health Emergency Preparedness and Response Division, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Chin  ); Xiao, Gang    (Department of Medical Laboratory, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Chin  ); Huang, Jing    (Department of Medical Laboratory, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Chin  ); Xiong, Yiquan    (Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, C  ); Li, Xiufen   Chen, Huifang   Zheng, Xueyan   Yu, Shouyi   Chen, Qing  
  • 초록  

    Human parechoviruses (HPeVs) are prevalent in young children; however, their effects are incompletely understood. We investigated the prevalence, genotype distribution, and phylogeny of HPeVs in individuals with diarrhea (n = 430) and healthy controls (n = 93) by the analysis of stool specimens collected from July 2013 to December 2014; 51 (11.86%) and 6 (6.45%) specimens were HPeV positive, respectively. HPeV1A occurred in 28 (6.51%) and 6 (6.45%) individuals with diarrhea and controls, respectively, whereas HPeV1B (3.95%), HPeV3 (0.23%), HPeV4 (0.70%), and HPeV14 (a rare genotype, 0.47%) were only detected in individuals with diarrhea. There was no significant difference in the rate of HPeV detection between the 2 groups; however, the mean age of HPeV infection was significantly lower in males. We conclude that HPeVs may be opportunistic pathogens associated with acute diarrhea. Immunocompromised individuals, such as children aged under 2 years and the elderly, could be vulnerable to HPeV infections.


  • 주제어

    child .   diarrhea .   genotype .   parechovirus .   phylogeny .   preschool .   prevalence.  

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