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Macromolecular bioscience v.18 no.7, 2018년, pp.1800096 -   

Strontium‐Substituted Hydroxyapatite‐Gelatin Biomimetic Scaffolds Modulate Bone Cell Response

Panzavolta, Silvia (Department of Chemistry “G. Ciamician”, University of Bologna, via Selmi, 2, Bologna, 40126, Italy ) ; Torricelli, Paola (Laboratory of Preclinical and Surgical Studies, IRCCS Rizzoli Orthopaedic Institute, via di Barbiano 1/10, 40136, Bologna, Italy ) ; Casolari, Sonia (Department of Chemistry “G. Ciamician”, University of Bologna, via Selmi, 2, Bologna, 40126, Italy ) ; Parrilli, Annapaola (Laboratory of Preclinical and Surgical Studies, IRCCS Rizzoli Orthopaedic Institute, via di Barbiano 1/10, 40136, Bologna, Italy ) ; Fini, Milena (Laboratory of Preclinical and Surgical Studies, IRCCS Rizzoli Orthopaedic Institute, via di Barbiano 1/10, 40136, Bologna, Italy ) ; Bigi, Adriana (Department of Chemistry “G. Ciamician”, University of Bologna, via Selmi, 2, Bologna, 40126, Italy ) ;
  • 초록  

    Abstract Strontium has a beneficial role on bone remodeling and is proposed for the treatment of pathologies associated to excessive bone resorption, such as osteoporosis. Herein, the possibility to utilize a biomimetic scaffold as strontium delivery system is explored. Porous 3D gelatin scaffolds containing about 30% of strontium substituted hydroxyapatite (SrHA) or pure hydroxyapatite (HA) are prepared by freeze‐drying. The scaffolds display a very high open porosity, with an interconnectivity of 100%. Reinforcement with further amount of gelatin provokes a modest decrease of the average pore size, without reducing interconnectivity. Moreover, reinforced scaffolds display reduced water uptake ability and increased values of mechanical parameters when compared to as‐prepared scaffolds. Strontium displays a sustained release in phosphate buffered saline: the quantities released after 14 d from as‐prepared and reinforced scaffolds are just 14 and 18% of the initial content, respectively. Coculture of osteoblasts and osteoclasts shows that SrHA‐containing scaffolds promote osteoblast viability and activity when compared to HA‐containing scaffolds. On the other hand, osteoclastogenesis and osteoclast differentiation are significantly inhibited on SrHA‐containing scaffolds, suggesting that these systems could be usefully applied for local delivery of strontium in loci characterized by excessive bone resorption.


  • 주제어

    biomimetic scaffolds .   gelatin .   reinforcement .   strontium release.  

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