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Macromolecular bioscience v.18 no.7, 2018년, pp.1800047 -   

An Extracellular Matrix‐Mimicking Hydrogel for Full Thickness Wound Healing in Diabetic Mice

Qin, Xianyan (Key Laboratory of Drug Targeting and Delivery, West China School of Pharmacy, Sichuan University, No. 17, Section 3, Southern Renmin Rd, Chengdu, 610041, China ) ; Qiao, Weizhen (Key Laboratory of Drug Targeting and Delivery, West China School of Pharmacy, Sichuan University, No. 17, Section 3, Southern Renmin Rd, Chengdu, 610041, China ) ; Wang, Yuejing (Key Laboratory of Drug Targeting and Delivery, West China School of Pharmacy, Sichuan University, No. 17, Section 3, Southern Renmin Rd, Chengdu, 610041, China ) ; Li, Tingyu (Key Laboratory of Drug Targeting and Delivery, West China School of Pharmacy, Sichuan University, No. 17, Section 3, Southern Renmin Rd, Chengdu, 610041, China ) ; Li, Xiang (Key Laboratory of Drug Targeting and Delivery, West China School of Pharmacy, Sichuan University, No. 17, Section 3, Southern Renmin Rd, Chengdu, 610041, China ) ; Gong, Tao ; Zhang, Zhi‐Rong ; Fu, Yao ;
  • 초록  

    Abstract An extracellular matrix‐mimicking hydrogel is developed consisting of a hyaluronan‐derived component with anti‐inflammatory activity, and a gelatin‐derived component offering adhesion sites for cell anchorage. The in situ‐forming hyaluronan‐gelatin (HA‐GEL) hydrogel displays a sponge‐like microporous morphology. Also, HA‐GEL shows a rapid swelling pattern reaching maximum weight swelling ratio within 10 min, while at the equilibrium state, fully swollen hydrogels display an exceedingly high water content with ≈2000% of the dry gel weight. Under typical 2D cell culture conditions, murine 3T3 fibroblasts adhere to, and proliferate on top of the HA‐GEL substrates, which demonstrate that HA‐GEL provides a favorable microenvironment for cell survival, adhesion, and proliferation. In vivo healing study further demonstrates HA‐GEL as a viable and effective treatment option to improve the healing outcome of full thickness wounds in diabetic mice by effectively depleting the inflammatory chemokine monocyte chemoattractant protein‐1 in the wound bed.


  • 주제어

    anti‐inflammation .   diabetic wound healing .   extracellular matrix .   hydrogel.  

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