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Macromolecular bioscience v.18 no.7, 2018년, pp.1800159 -   

Efficiency of Biodegradable and pH‐Responsive Polysuccinimide Nanoparticles (PSI‐NPs) as Smart Nanodelivery Systems in Grapefruit: In Vitro Cellular Investigation

Xin, Xiaoping (Department of Soil and Water Sciences, Indian River Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Fort Pierce, FL, 34945, USA ) ; He, Zhenli (Department of Soil and Water Sciences, Indian River Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Fort Pierce, FL, 34945, USA ) ; Hill, Megan R. (George and Josephine Butler Polymer Research Laboratory, Department of Chemistry, Center for Macromolecular Science and Engineering, University of Florida, Gainesville, FL, 32611, USA ) ; Niedz, Randall P. (USDA‐ARS U.S. Horticultural Research Laboratory, Fort Pierce, FL, 34945, USA ) ; Jiang, Xianjun (College of Resources and Environment, Southwest University, Beibei, Chongqing, 400715, China ) ; Sumerlin, Brent S. (George and Josephine Butler Polymer Research Laboratory, Department of Chemis ) ;
  • 초록  

    Abstract Biodegradable pH‐responsive polysuccinimide nanoparticles (PSI‐NPs) are synthesized for directly delivering agrochemicals to plant phloem to improve their efficacy. The PSI‐NPs have an average size of 20.6 nm with negative charge on the surface. The desired responsiveness to changes in pH is demonstrated by release efficiency of the model molecule (Coumarin 6), which increases with increasing pH over 24 h. The internalization of PSI‐NPs into grapefruit cells occurs in 10 min, and into nucleus in 2 h, with most of the PSI‐NPs being distributed in cytoplasm and nucleus. The proportion of PSI‐NPs in plant cells significantly increases with time, from 19.1% at 10 min to 55.5% at 2 h of administering. The PSI‐NPs do not show significant inhibitory effects on soil microbial growth and activity. These results indicate that this smart nanodelivery system has potential of application in agriculture for mitigating phloem‐limited diseases, such as citrus huanglongbing.


  • 주제어

    cellular internalization .   citrus HLB .   microbial toxicity .   polymeric nanoparticles .   release efficiency.  

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