본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Electrospray ionization study of tricarbonyl fac‐[Re(CO)3(PO)(X)]‐type complexes: influence of ancillary co‐ligands in the release of carbon monoxide

Tisato, Francesco (CNR – ) ; Porchia, Marina (ICMATE, Corso Stati Uniti 4, 35127, Padova, Italy ) ; Shegani, Antoni (CNR – ) ; Maina, Theodosia (ICMATE, Corso Stati Uniti 4, 35127, Padova, Italy ) ; Papadopoulos, Minas S. (INRaSTES, NCSR “Demokritos”, 15310 Ag. Paraskevi Attikis, Athens, Greece ) ; Seraglia, Roberta (INRaSTES, NCSR “Demokritos”, 15310 Ag. Paraskevi Attikis, Athens, Greece ) ; Traldi, Pietro (INRaSTES, NCSR “Demokritos”, 15310 Ag. Paraskevi Attikis, Athens, Greece ) ;
  • 초록  

    Rationale fac ‐[Re(CO) 3 (PO)(X)]‐type complexes (PO = chelated bidentate tertiary phosphine (1‐), X = various neutral, mono‐dentate ligands) represent a class of compounds that meets the synthetic criteria for the preparation of potential carbon monoxide (CO) release molecules (CORMs) for medicinal application. The aim of our investigation was to achieve qualitative information whether the nature of the ancillary X ligand might influence the release of CO. Methods The release of CO has been investigated by means of product ion spectrometry of electrospray ionization (ESI)‐generated [M + H] + species, produced by multiple collisional experiments, using an ion trap mass spectrometer. Results Tandem mass spectrometry applied to the protonated species [Re(CO) 3 (PO)(X) + H] + of seven complexes (those including X = OH 2 ( 1 ), isonitrile ( 2 , 3 ), imidazole ( 4 ), pyridine ( 5 ) and phosphine ( 6 , 7 )) shows initial loss of coordinated water ( 1 ) or pyridine ( 5 ), whereas the majority of investigated entries display initial, sequential release of CO groups. The energetics of CO release have been investigated by breakdown curves for selected collisionally activated decomposition processes involving CO, and compared with those involving X groups. Conclusions The nature of the co‐ligand X drives the primary loss in the MS n processes of [Re(CO) 3 (PO)(X) + H] + compounds. When X = solvent, the energetics of these decompositions follow the trend H 2 O n pathways indicate that [Re(PO)] (Re with chelated PO phosphine) constitutes the residual moiety. This behavior indicates that the presence of a functionalized phosphine is essential for a sequential, controlled release of CO.


 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기