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Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Soci v.24 no.3, 2018년, pp.445 - 449   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Non‐invasive evaluation of human mucosal structures by multiphoton laser scanning tomography in vitro

Springer, S. (Department of Dermatology, University Hospital Jena, Jena, Germany ) ; Zieger, M. (Department of Dermatology, University Hospital Jena, Jena, Germany ) ; Hipler, U. C. (Department of Dermatology, University Hospital Jena, Jena, Germany ) ; König, K. (JenLab GmbH, Jena, Germany ) ; Lademann, J. (Department of Dermatology, Venereology and Allergology, Center of Experimental and Cutaneous Physiology (CCP), Charité‐Universitätsmedizin Berlin, Berlin, Germany ) ; Kaatz, M. (Department of Dermatology, University Hospital Jena, Jena, Germany ) ; Koehler, M. J. (Department of Dermatology, University Hospital Jena, Jena, Germany ) ;
  • 초록  

    Abstract Background Mucous membranes may be affected by various diseases and the diagnostic accessibility is limited. Multiphoton laser tomography (MPT) is a useful tool for in vivo evaluation of superficial skin structures and might also be useful for the imaging of mucosa. Objectives In order to investigate the suitability of MPT for the evaluation of mucous membranes, tissue samples of different donors and anatomical localizations have been imaged. Methods Human mucosa samples from the urinary bladder, palatine tonsil and ocular conjunctiva were investigated by MPT and subsequently compared with conventional histology. Results Horizontal images of the epithelium and the underlying connective tissue were obtained using the autofluorescence and second harmonics generation signals by MPT. The stratification of multilayered epithelium was consistently reproduced. Also inflammatory changes like lymphocytic infiltrates and widened intercellular spaces were imaged in some cases. Conclusion Mucous tissue samples were obtained and MPT imaging was successfully performed. In the direct comparison with histology of the same tissue samples, the characteristic morphology of the epithelia was found. Further studies are necessary in order to compare images of healthy and diseased mucosal epithelium and the use of MPT for its evaluation in vivo.


  • 주제어

    autofluorescence .   bladder .   conjunctiva .   mucosa .   multiphoton laser scanning tomography .   palatine tonsil .   second harmonic generation.  

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