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Traffic v.19 no.8, 2018년, pp.569 - 577   SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Tying trafficking to fusion and fission at the mighty mitochondria

Farmer, Trey (The Department of Biochemistry and Molecular Biology, The University of Nebraska Medical Center, Omaha, Nebraska ) ; Naslavsky, Naava (The Department of Biochemistry and Molecular Biology, The University of Nebraska Medical Center, Omaha, Nebraska ) ; Caplan, Steve (The Department of Biochemistry and Molecular Biology, The University of Nebraska Medical Center, Omaha, Nebraska ) ;
  • 초록  

    The mitochondrion is a unique organelle that serves as the main site of ATP generation needed for energy in the cell. However, mitochondria also play essential roles in cell death through apoptosis and necrosis, as well as a variety of crucial functions related to stress regulation, autophagy, lipid synthesis and calcium storage. There is a growing appreciation that mitochondrial function is regulated by the dynamics of its membrane fusion and fission; longer, fused mitochondria are optimal for ATP generation, whereas fission of mitochondria facilitates mitophagy and cell division. Despite the significance of mitochondrial homeostasis for such crucial cellular events, the intricate regulation of mitochondrial fusion and fission is only partially understood. Until very recently, only a single mitochondrial fission protein had been identified. Moreover, only now have researchers turned to address the upstream machinery that regulates mitochondrial fusion and fission proteins. Herein, we review the known GTPases involved in mitochondrial fusion and fission, but also highlight recent studies that address the mechanisms by which these GTPases are regulated. In particular, we draw attention to a substantial new body of literature linking endocytic regulatory proteins, such as the retromer VPS35 cargo selection complex subunit, to mitochondrial homeostasis. These recent studies suggest that relationships and cross‐regulation between endocytic and mitochondrial pathways may be more widespread than previously assumed.


  • 주제어

    dynamin2 .   dynamin‐related protein‐1 .   Eps15 homology domain‐containing protein 1 .   fission .   fusion .   homeostasis .   mitochondria .   Mitofusin‐1 .   Mitofusin‐2 .   optic atrophy protein 1 .   Rabankyrin‐5 .   retromer .   vacuole protein sorting 35.  

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