본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Clinical transplantation v.32 no.9, 2018년, pp.e13372 -    SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Ten‐year observational follow‐up of a randomized trial comparing cyclosporine and tacrolimus therapy combined with steroid withdrawal in living‐donor renal transplantation

Kim, Jinhae (Division of Nephrology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea ) ; Park, Jeeeun (Division of Nephrology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea ) ; Hwang, Subin (Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea ) ; Yoo, Heejin (Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea ) ; Kim, Kyunga (Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea ) ; Park, Jae Berm (Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea ) ; Jang, Hye Ryoun (Division of Nephrology, Department of Medicine, Samsung Medical Center, Sungkyunkwan ) ; Lee, Jung Eun ; Kim, Sung‐Joo ; Kim, Yoon‐Goo ; Kim, Dae Joong ; Oh, Ha Young ; Huh, Wooseong ;
  • 초록  

    Although various strategies for steroid withdrawal after transplantation have been attempted, there are few reports of the long-term results of steroid withdrawal regimens in kidney transplantation. Earlier, we reported on a 5-year prospective, randomized, single-center trial comparing the safety and efficacy of cyclosporine (CsA) plus mycophenolate mofetil (MMF) with that of tacrolimus (TAC) plus MMF, when steroids were withdrawn 6 months after kidney transplantation in low-risk patients. We now report the 10-year observational data on the study population. We collected data from the database of the Organ Transplantation Center, Samsung Medical Center for 5 years after completion of the original study (TAC group n = 62; CsA group n = 55). The 10-year patient survival, death-censored graft survival, and acute rejection-free survival did not differ between groups (98% vs 96%; P = 0.49, 78% vs 85%; P = 0.75 and 84% vs 76%; P = 0.14 in the TAC group vs CsA group, respectively). In low-risk patients, there was no difference in long-term patient and graft survival between TAC- and CsA-based late steroid withdrawal regimens that included MMF treatment. More long-term randomized clinical trials are needed to clarify the benefits of late steroid withdrawal in kidney transplantation.


  • 주제어

    cyclosporine .   graft survival .   kidney transplantation .   steroid withdrawal .   tacrolimus.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기