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Journal of behavioral addictions v.7 no.1, 2018년, pp.192 - 203   SCIE SSCI
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Pro-dopamine regulator, KB220Z, attenuates hoarding and shopping behavior in a female, diagnosed with SUD and ADHD

McLaughlin, Thomas    (Department of Psychopharmacology, Center for Psychiatric Medicine , Lawrence, MA, USA  ); Blum, Kenneth    (Department of Psychiatry, Boonshoft School of Medicine, Dayton VA Medical Center, Wright State University , Dayton, OH, USA  ); Steinberg, Bruce    (Department of Psychology, Curry College , Milton, MA, USA  ); Modestino, Edward J.    (Department of Psychology, Curry College , Milton, MA, USA  ); Fried, Lyle    (Division of Neuroscience Based Addiction Therapy, The Shores Treatment & Recovery Center , Port Saint Lucie, FL, USA  ); Baron, David    (Department of Psychiatry and Behavioral Sciences, Keck Medicine University of Southern California , Los Angeles, CA, USA  ); Siwicki, David    (Department of Precision Medicine, Geneus Health LLC , San Antonio, TX, USA  ); Braverman, Eric R.    (Department of Clinical Neurology, Path Foundation , New York, NY, USA  ); Badgaiyan, Rajendra D.    (Department of Psychiatry, Icahn School of Medicine , Staten Island, NY, USA <countr  );
  • 초록  

    Background Addictive-like behaviors (e.g., hoarding and shopping) may be the result of the cumulative effects of dopaminergic and other neurotransmitter genetic variants as well as elevated stress levels. We, therefore, propose that dopamine homeostasis may be the preferred goal in combating such challenging and unwanted behaviors, when simple dopaminergic activation through potent agonists may not provide any resolution. Case presentation C.J. is a 38-year-old, single, female, living with her mother. She has a history of substance use disorder as well as attention deficit hyperactivity disorder, inattentive type. She had been stable on buprenorphine/naloxone combination and amphetamine, dextroamphetamine mixed salts for many years when unexpectedly she lost her job for oversleeping and not calling into work. KB200z (a pro-dopamine compound) was added to her regimen for complaints of low drive and motivation. After taking this nutraceutical for 4 weeks, she noticed a marked improvement in her mental status and many behaviors. She noted that her shopping and hoarding addictions had appreciably decreased. Furthermore, her lifelong history of terrifying lucid dreams was eliminated. Finally, she felt more in control; her locus of control shifted from external to more internal. Discussion The hypothesis is that C.J.'s reported, behavioral, and psychological benefits resulted from the pro-dopamine-regulating effect of KB220Z across the brain reward system. Conclusions This effect, we surmise, could be the result of a new dopamine balance, across C.J.'s brain reward system. Dopamine homeostasis is an effect of KB220Z seen in both animal and human placebo-controlled fMRI experiments.


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