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Journal of cancer prevention v.23 no.1, 2018년, pp.25 - 36  

Lycopene Protects Against Spontaneous Ovarian Cancer Formation in Laying Hens

Sahin, Kazim    (Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey  ); Yenice, Engin    (Poultry Research Institute, Ankara, Turkey  ); Tuzcu, Mehmet    (Division of Biology, Faculty of Science, Firat University, Elazig, Turkey  ); Orhan, Cemal    (Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey  ); Mizrak, Cengizhan    (Poultry Research Institute, Ankara, Turkey  ); Ozercan, Ibrahim H.    (Department of Pathology, Faculty of Medicine, Firat University, Elazig, Turkey  ); Sahin, Nurhan    (Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey  ); Yilmaz, Bahiddin    (Winship Cancer Institute of Emory University, Atlanta, GA, USA  ); Bilir, Birdal    (Winship Cancer Institute of Emory University, Atlanta, GA, USA  ); Ozpolat, Bulent    (Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Hous  ); Kucuk, Omer  
  • 초록

    Background Dietary intake of lycopene has been associated with a reduced risk of ovarian cancer, suggesting its chemopreventive potential against ovarian carcinogenesis. Lycopene's molecular mechanisms of action in ovarian cancer have not been fully understood. Therefore, in the present study, we investigated the effects of lycopene on the ovarian cancer formation using the laying hen model, a biologically relevant animal model of spontaneous ovarian carcinogenesis due to high incidence rates similar to humans. Methods In this study, a total of 150 laying hens at age of 102 weeks were randomized into groups of 50: a control group (0 mg of lycopene per kg of diet) and two treatment groups (200 mg or 400 mg of lycopene per kg of diet, or ~26 and 52 mg/d/hen, respectively). At the end of 12 months, blood, ovarian tissues and tumors were collected. Results We observed that lycopene supplementation significantly reduced the overall ovarian tumor incidence ( P P P P P Conclusions Taken together, our findings strongly support the potential of lycopene in the chemoprevention of ovarian cancer through antioxidant and anti-inflammatory mechanisms.


  • 주제어

    Lycopene .   Ovarian cancer .   Laying hen model .   Chemoprevention .   Transcription factors.  

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