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Journal of neurogastroenterology and motility v.24 no.2, 2018년, pp.255 - 267   SCIE SCOPUS
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Axial Movements and Length Changes of the Human Lower Esophageal Sphincter During Respiration and Distension-induced Secondary Peristalsis Using Functional Luminal Imaging Probe

Liao, Donghua    (GIOME Academia, Department of Medicine, Aarhus University, Aarhus, Denmark  ); Lottrup, Christian    (Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark  ); Fynne, Lotte    (Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark  ); McMahon, Barry P    (TAGG Research Center, Tallaght Hospital and Trinity College, Dublin, Ireland  ); Krogh, Klaus    (Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark  ); Drewes, Asbjørn M    (Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark  ); Zhao, Jingbo    (GIOME Academia, Department of Medicine, Aarhus University, Aarhus, Denmark  ); Gregersen, Hans    (GIOME, Department of Surgery, Chinese University of Hong Kong and Prince of Wales Hospital, Hong Kong  );
  • 초록

    Background/Aims Efficient transport through the esophago-gastric junction (EGJ) requires synchronized circular and longitudinal muscle contraction of the esophagus including relaxation of the lower esophageal sphincter (LES). However, there is a scarcity of technology for measuring esophagus movements in the longitudinal (axial) direction. The aim of this study is to develop new analytical tools for dynamic evaluation of the length change and axial movement of the human LES based on the functional luminal imaging probe (FLIP) technology and to present normal signatures for the selected parameters. Methods Six healthy volunteers without hiatal hernia were included. Data were analyzed from stepwise LES distensions at 20, 30, and 40 mL bag volumes. The bag pressure and the diameter change were used for motion analysis in the LES. The cyclic bag pressure frequency was used to distinguish dynamic changes of the LES induced by respiration and secondary peristalsis. Results Cyclic fluctuations of the LES were evoked by respiration and isovolumetric distension, with phasic changes of bag pressure, diameter, length, and axial movement of the LES narrow zone. Compared to the respiration-induced LES fluctuations, peristaltic contractions increased the contraction pressure amplitude ( P P P P Conclusions FLIP can be used for evaluation of dynamic length changes and axial movement of the human LES. The method may shed light on abnormal longitudinal muscle activity in esophageal disorders.


  • 주제어

    Distension .   Esophageal sphincter .   lower .   Longitudinal .   Motion.  

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