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Experimental and molecular pathology 19건

  1. [해외논문]   Editorial Board  


    Experimental and molecular pathology v.103 no.2 ,pp. IFC , 2017 , 0014-4800 ,

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  2. [해외논문]   Editorial Board   SCIE SCOPUS


    Experimental and molecular pathology v.103 no.2 ,pp. IFC - IFC , 2017 , 0014-4800 ,

    초록

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Effects of single or combined induction of diabetes mellitus and knee osteoarthritis on some biochemical and haematological parameters in rats   SCIE SCOPUS

    Adeyemi, Wale J. (Corresponding author at: P. O. Box 6593, Ilorin, Kwara State, Nigeria.) , Olayaki, Luqman A.
    Experimental and molecular pathology v.103 no.2 ,pp. 113 - 120 , 2017 , 0014-4800 ,

    초록

    Abstract Clinical evidences on the coexistence of diabetes mellitus (DM) and osteoarthritis (OA) dated back to the 1960s. Therefore, the study investigated the effects of induced DM and/or knee osteoarthritis (KOA) on some biochemical and haematological parameters in adult male Wistar rats. Twenty rats were used for this study. They were randomly divided into 4 groups (N=5 rats) which included: Normal control; Osteoarthritic (OA) control; Diabetic control; and, Diabetic+Osteoarthritic (D+OA) control. DM was induced in overnight fasted rats by the administration of streptozotocin (65mg/kg b.w., i.p. ) 15min after the administration of nicotinamide (110mg/kg, b.w., i.p. ). However, KOA was induced by the intra-articular injection of 4mg of sodium monoiodoacetate in 40μl of normal saline. In the D+OA group, KOA was induced about 12h after the induction of DM. The rats were left untreated for four weeks. Afterwards, the experiment was terminated. The results showed that both DM and OA featured hypercortisolism and dyslipidaemia. The additive effects of both conditions were observed on the lipid profile and some haematological indices in the D+OA group. Unlike DM, OA had mild adverse effects on the haematological profile. Nevertheless, it significantly contributed to hyperglycaemia in the D+OA group, even though it had no significant effect on the insulin resistance. However, the hypocalcaemic and glycogenolytic effects of DM were negated by OA. In conclusion, the coexistence of DM and OA presents a greater challenge on the biochemical and haematological profiles than the individual disease. But, this prediction could sometimes be annulled by the intervention of endogenous homeostatic mechanisms. Highlights In the presence of diabetes (DM), osteoarthritis (OA) worsens glycaemic control. Unlike DM, OA has mild adverse effects on the haematological profile. Although DM and OA share certain features, they could also negate each other. Homeostatic mechanisms could abate the effects of the coexistence of DM and OA. Adverse effects of the coexistence of DM and OA are more than in each condition.

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  4. [해외논문]   African medicinal plants and their derivatives: Current efforts towards potential anti-cancer drugs   SCIE SCOPUS

    Mbele, Mzwandile (Corresponding author.) , Hull, Rodney , Dlamini, Zodwa
    Experimental and molecular pathology v.103 no.2 ,pp. 121 - 134 , 2017 , 0014-4800 ,

    초록

    Abstract Cancer is a leading cause of mortality and morbidity worldwide and second only to cardiovascular diseases. Cancer is a challenge in African countries because generally there is limited funding available to deal with the cancer epidemic and awareness and this should be prioritised and all possible resources should be utilized to prevent and treat cancer. The current review reports on the role of African medicinal plants in the treatment of cancer, and also outlines methodologies that can also be used to achieve better outcomes for cancer treatment. This review outlines African medicinal plants, isolated compounds and technologies that can be used to advance cancer research. Chemical structures of isolated compounds have an important role in anti-cancer treatments; new technologies and methods may assist to identify more properties of African medicinal plants and the treatment of cancer. In conclusion, African medicinal plants have shown their potential as enormous resources for novel cytotoxicity compounds. Finally it has been noted that the cytotoxicity depends on the chemical structural arrangements of African medicinal plants compounds.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Is the diagnosis of acute luminal appendicitis clinically meaningful?   SCIE SCOPUS

    Byers, Joshua T. (Corresponding author.) , French, Samuel W.
    Experimental and molecular pathology v.103 no.2 ,pp. 135 - 136 , 2017 , 0014-4800 ,

    초록

    Abstract Cancer is a leading cause of mortality and morbidity worldwide and second only to cardiovascular diseases. Cancer is a challenge in African countries because generally there is limited funding available to deal with the cancer epidemic and awareness and this should be prioritised and all possible resources should be utilized to prevent and treat cancer. The current review reports on the role of African medicinal plants in the treatment of cancer, and also outlines methodologies that can also be used to achieve better outcomes for cancer treatment. This review outlines African medicinal plants, isolated compounds and technologies that can be used to advance cancer research. Chemical structures of isolated compounds have an important role in anti-cancer treatments; new technologies and methods may assist to identify more properties of African medicinal plants and the treatment of cancer. In conclusion, African medicinal plants have shown their potential as enormous resources for novel cytotoxicity compounds. Finally it has been noted that the cytotoxicity depends on the chemical structural arrangements of African medicinal plants compounds.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   The role of the IL-8 signaling pathway in the infiltration of granulocytes into the livers of patients with alcoholic hepatitis   SCIE SCOPUS

    French, S.W. (Corresponding author.) , Mendoza, A.S. , Afifiyan, N. , Tillman, B. , Vitocruz, E. , French, B.A.
    Experimental and molecular pathology v.103 no.2 ,pp. 137 - 140 , 2017 , 0014-4800 ,

    초록

    Abstract Background and aim IL-8 (C-X-L motif chemokine ligase 8) and CXCR2 (C-X-C-motif chemokine receptor 2) are up regulated in alcoholic hepatitis (AH) liver biopsies. One of the consequences is the attraction and chemotactic neutrophilic infiltrate seen at the AH stage of alcoholic liver disease. Materials and methods Human formalin-fixed, paraffin-embedded (FFPE) liver biopsies from patients who have AH were studied by (2.1) RNA sequencing, (2.2) PCR and (2.3) semi quantitation of specific proteins in biopsy sections using immunohistochemical measurements of antibody fluorescent intensity with morphometric technology. Results Immunohistochemistry of IL-8 showed that the expression was increased in the cytoplasm of the hepatocytes in AH liver biopsies compared to the controls. IL-8 and ubiquitin were co-localized in the MDBs. Numerous neutrophils were found throughout and satellitosis of neutrophils around MDBs was present. This suggested that IL-8 may be involved in MDB pathogenesis. RNA seq analysis revealed activation by IL-8 which included neutrophil chemotaxis by LIM domain kinase 2 (LIMK2) (17.5 fold increase) and G protein subunit alpha 15 (GNA15) (27.8 fold increase). Conclusions The formation of MDBs by liver cells showed colocalization of ubiquitin and IL-8 in the MDBs. This suggested that IL-8 in these hepatocytes attracted the neutrophils to form satellitosis. This correlated with up regulation of the proteins downstream from the IL-8 pathways including LIMK2, GNG2 (guanine nucleotide binding proteins) and PIK3CB (phosphatidyl isitol-4, 5-biophosphate-3-kinase, catalytic subunit beta).

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Regulation of autoimmune myocarditis by host responses to the microbiome   SCIE SCOPUS

    Barin, Jobert G. (The Johns Hopkins University School of Medicine, Dept. of Pathology, Div. of Immunology, Baltimore, MD 21205, United States ) , Talor, Monica V. (The Johns Hopkins University School of Medicine, Dept. of Pathology, Div. of Immunology, Baltimore, MD 21205, United States ) , Diny, Nicola L. (The Johns Hopkins Bloomberg School of Public Health, The W. Harry Feinstone Dept. of Molecular Microbiology & Immunology, United States ) , Ong, SuFey (The Johns Hopkins Bloomberg School of Public Health, The W. Harry Feinstone Dept. of Molecular Microbiology & Immunology, United States ) , Schaub, Julie A. (The Johns Hopkins University School of Medicine, Dept. of Pathology, Div. of Immunology, Baltimore, MD 21205, United States ) , Gebremariam, Elizabeth (The Johns Hopkins University School of Medicine, Dept. of Pathology, Div. of Immunology, Baltimore, MD 21205, United States ) , Bedja, Djahida (The Johns Hopkins University School of Medicine, Dept. of Cardiology, United States ) , Chen, Guobao (The Johns Hopkins University School of Medicine, Dept. of Pathology, Div. of Immunology, Baltimore, MD 21205, United States ) , Choi, Hee Sun (The John) , Hou, Xuezhou , Wu, Lei , Cardamone, Ashley B. , Peterson, Daniel A. , Rose, Noel R. , Č , ihá , ková , , Daniela
    Experimental and molecular pathology v.103 no.2 ,pp. 141 - 152 , 2017 , 0014-4800 ,

    초록

    Abstract The extensive, diverse communities that constitute the microbiome are increasingly appreciated as important regulators of human health and disease through inflammatory, immune, and metabolic pathways. We sought to elucidate pathways by which microbiota contribute to inflammatory, autoimmune cardiac disease. We employed an animal model of experimental autoimmune myocarditis (EAM), which results in inflammatory and autoimmune pathophysiology and subsequent maladaptive cardiac remodeling and heart failure. Antibiotic dysbiosis protected mice from EAM and fibrotic cardiac dysfunction. Additionally, mice derived from different sources with different microbiome colonization profiles demonstrated variable susceptibility to disease. Unexpectedly, it did not track with segmented filamentous bacteria (SFB)-driven Th17 programming of CD4 + T cells in the steady-state gut. Instead, we found disease susceptibility to track with presence of type 3 innate lymphoid cells (ILC3s). Ablating ILCs by antibody depletion or genetic tools in adoptive transfer variants of the EAM model demonstrated that ILCs and microbiome profiles contributed to the induction of CCL20/CCR6-mediated inflammatory chemotaxis to the diseased heart. From these data, we conclude that sensing of the microbiome by ILCs is an important checkpoint in the development of inflammatory cardiac disease processes through their ability to elicit cardiotropic chemotaxis.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Can Ocimum basilicum relieve chronic unpredictable mild stress-induced depression in mice?   SCIE SCOPUS

    Ayuob, Nasra Naeim (Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia ) , Firgany, Alaa El-Din L. (Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt ) , El-Mansy, Ahmed A. (Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt ) , Ali, Soad (Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia)
    Experimental and molecular pathology v.103 no.2 ,pp. 153 - 161 , 2017 , 0014-4800 ,

    초록

    Abstract Background Depression is one of the important world-wide health problems. Objectives This study aimed to assess the ameliorative effect of Ocimum basilicum (OB) essential oil on the behavioral, biochemical and histopathological changes resulted from exposure to chronic unpredictable mild stress (CUMS). It also aimed to investigate the underlying mechanism in an animal model of depression. Materials and methods Forty male Swiss albino mice were divided into four groups (n=10): control, CUMS (exposed to CUMS for 4weeks), CUMS plus fluoxetine, and CUMS plus OB. At the end of the experiment, behavioral changes, serum corticosterone level, protein and gene expressions of brain derived neurotropic factor (BDNF) and glucocorticoid receptors (GR) in the hippocampus was all assessed. Immunoexpression of surface makers of glial fibrillary acidic protein (GFAP), Ki67, Caspase-3, BDNF and GR in the hippocampus were estimated. Data were analyzed by using the statistical package for the social sciences (SPSS). Results OB alleviated both behavioral and biochemical changes recorded in mice after exposure to CUMS. It also reduced neuronal atrophy observed in the hippocampal region III cornu ammonis (CA3) and dentate gyrus and restored back astrocyte number. OB decreased apoptosis in both neurons and glial cells and increased neurogenesis in the dentate gyrus in a pattern comparable to that of fluoxetine. Increased BDNF and GR gene and protein expressions seems to be behind the antidepressant-like effect of OB. Conclusion Ocimum basilicum ameliorates the changes induced after exposure to the chronic stress. Assessing Ocimum basilicum efficacy on human as antidepressant is recommended in further studies.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Change in nomenclature for the immunologic synapse from Troxis Necrosis to trogocytosis   SCIE SCOPUS

    French, Samuel W.
    Experimental and molecular pathology v.103 no.2 ,pp. 162 - 162 , 2017 , 0014-4800 ,

    초록

    Abstract The immunologic synapse mechanism of liver necrosis was termed Troxis Necrosis meaning “nibbling”. (Wang MX et al. and French SW. Exp Mol Pathol 2001, 71: 137–146). This mechanism of liver injury was first named “Piecemeal Necrosis” by Hans Popper. It is involved in autoimmune hepatitis, HCV, HBV, primary biliary cirrhosis and steatohepatitis. This process involves the T cell receptor (TCR) which binds to the hepatocyte antigen presenting major histocompatibility complex (MHC) on the hepatocytic plasma membrane which quickly leads to the removal of the complex from the liver and uptake by the CD4 lymphocyte. This process is performed by the immunologic synapse now called trogocytosis meaning “gnaw” (Martinez-Martin N et al., Immunity 2011, 35: 208–222 and Dustin ML, Cancer Immunol Res 2014, 2: 1023–1033). The repeated episodes of uptake of the hepatocyte bite by bite causes the hepatocyte to slowly disappear like the Cheshire cat. This immunological synapse process is also involved in drug hepatitis, Hashimoto's thyroiditis, type I diabetes, autoimmune adrenalitis, autoimmune gastritis and cancer therapy. Treatment of Alzheimer's disease is also now being studied with PD-L1 antibody as used in the treatment of cancer allowing recruitment of disease modifying leukocytes to the sites of brain pathology (Schwartz M. Science 2017, 357: 254–255). Acknowledgement: Supported by a Grant from NIAAA UO1-021898 .

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [해외논문]   5-gene differential expression predicts stability of human intestinal allografts   SCIE SCOPUS

    Talayero, Paloma (Department of Immunology, University Hospital 12 de Octubre, Madrid, Spain ) , Alonso-Guirado, Lola (Bioinformatics and Biostatistics Unit, Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain ) , Padilla, Guillermo (Bioinformatics and Biostatistics Unit, Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain ) , Artaza, Haydee (Bioinformatics and Biostatistics Unit, Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain ) , Dopazo, Ana (Genomics Unit, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain ) , Sá (Bioinformatics Unit, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain ) , nchez-Cabo, Fá (Department of Gastroenterology, University Hospital 12 de Octubre, Madrid, Spain ) , tima (Department of General and Digestive Surgery and Abdominal Organ Transplantation, University Hospital 12 de Octubre, Madrid, Spain ) , Rodrí (Department of Immunology, University Hospital 12 de Octubre, Madrid, Spain ) , guez-Muñ (Bioinformatics and Biostatistics Unit, Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain ;) , oz, Sarbelio , Calvo-Pulido, Jorge , Mancebo, Esther , de Lacoba, Mario Garcí , a , Paz-Artal, Estela
    Experimental and molecular pathology v.103 no.2 ,pp. 163 - 171 , 2017 , 0014-4800 ,

    초록

    Abstract In intestinal allografts, endoscopy and histology detect the injury once changes in the bowel wall architecture have occurred. We aimed to identify a molecular signature that could predict early deterioration, within histologically indistinguishable biopsies with “minimal changes” (MC) pathology. Sixty biopsies from 12 adult recipients were longitudinally taken during 8years post-transplant. They were classified as either stable (STA) or non-stable (NSTA) according to the prospectively recorded number, frequency and severity of rejection events of the allograft. In a discovery set of MC samples analyzed by RNA-Seq, 816 genes were differentially expressed in STA vs NSTA biopsies. A group of 5 genes (ADH1C, SLC39A4, CYP4F2, OPTN and PDZK1) correctly classified all NSTA biopsies in the discovery set and all STA biopsies from an independent set. These results were validated by qPCR in a new group of MC biopsies. Based on a logistic regression model, a cutoff of 0.28 predicted the probability of being a NSTA biopsy with 85% sensitivity and 69% specificity. In conclusion, by analyzing MC samples early after transplantation, the expression of a 5-gene set may predict the evolution of the bowel allograft. This prognostic biomarker may be of help to personalize care of the intestinal transplant recipient. Highlights RNA-Sequencing is a highly sensitive tool for biomarker discovery. Apparently histologically equal biopsies are molecularly different. A 5-gene signature may be able to predict intestinal graft stability.

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