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Gynecologic oncology 42건

  1. [해외논문]   Reviewer Acknowledgement 2017   SCI SCIE


    Gynecologic oncology v.147 no.3 ,pp. I - IV , 2017 , 0090-8258 ,

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   Editorial Board   SCI SCIE


    Gynecologic oncology v.147 no.3 ,pp. viii - viii , 2017 , 0090-8258 ,

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   A call to standardize our approach to fertility-sparing surgery in patients with gynecologic cancers   SCI SCIE

    Aviki, Emeline M. (Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA ) , Abu-Rustum, Nadeem R. (Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA)
    Gynecologic oncology v.147 no.3 ,pp. 491 - 492 , 2017 , 0090-8258 ,

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Fertility-preserving surgery for advanced stage ovarian germ cell tumors   SCI SCIE

    Nasioudis, Dimitrios (Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA ) , Frey, Melissa K. (Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA ) , Chapman-Davis, Eloise (Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA ) , Caputo, Thomas A. (Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA ) , Holcomb, Kevin (Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA)
    Gynecologic oncology v.147 no.3 ,pp. 493 - 496 , 2017 , 0090-8258 ,

    초록

    Abstract Objective To evaluate the prevalence and safety of uterine preservation among premenopausal women diagnosed with a malignant ovarian germ-cell tumor (MOGCT) of advanced stage (stage II-IV). Materials and methods The National Cancer Database was accessed and a cohort of women aged Results A total of 526 eligible patients were identified; rate of hysterectomy was 20.2%. Women who had a hysterectomy were older (median age 30.5 vs 20years, p Conclusions Uterine preservation was not associated with decreased survival and should be considered in women with advanced stage GCTs interested in future fertility. Highlights Rate of uterine preservation among women with advanced stage MOGCTs was 79.8%. Uterine preservation was not associated with a decreased survival. FSS should be considered in women with advanced stage MOGCTs interested in future fertility.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Factors influencing fertility-sparing treatment for gynecologic malignancies: A survey of Society of Gynecologic Oncology members   SCI SCIE

    Shah, Jaimin S. (Department of Obstetrics and Gynecology, UT Health, The University of Texas at Houston, McGovern Medical School, United States ) , Guerra, Rosa (Department of Obstetrics and Gynecology, UT Health, The University of Texas at Houston, McGovern Medical School, United States ) , Bodurka, Diane C. (Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States ) , Sun, Charlotte C. (Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States ) , Chisholm, Gary B. (Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States ) , Woodard, Terri L. (Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States)
    Gynecologic oncology v.147 no.3 ,pp. 497 - 502 , 2017 , 0090-8258 ,

    초록

    Abstract Objectives This study aims to examine practice patterns of gynecologic oncologists (GO) regarding fertility-sparing treatments (FST) for gynecology malignancies and explores attitudes toward collaboration with reproductive endocrinologists (RE). Methods An anonymous 23-question survey was sent to 1087 GO with a 14.0% completion rate. Descriptive statistics, Fisher's exact test, and Chi-square tests were used for data analysis. Results The majority of GOs offer FST for gynecologic malignancies. Providers seeing larger numbers of reproductive age women were more likely to consider cancer prognosis ( p p p p p p Conclusions While FST offers women the chance to pursue pregnancy after cancer, there are minimal data on factors that influence whether FST is offered and if collaboration with a RE is sought in the management of these patients. The number of reproductive age women seen, geographic location, and practice setting are important variables that may influence current practice. Understanding these factors can help identify opportunities to improve oncologic and reproductive outcomes of this patient population. Highlights Number of reproductive aged women seen may influence fertility sparing treatment. Geographic region and practice setting also influences fertility sparing treatment. Most of the gynecologic oncologists felt collaborating with a RE was important. Collaboration can help optimize treatment planning for women considering a FST.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Intraperitoneal disease dissemination patterns are associated with residual disease, extent of surgery, and molecular subtypes in advanced ovarian cancer   SCI SCIE

    Torres, Diogo (Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, United States ) , Kumar, Amanika (Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, United States ) , Wallace, Sumer K. (Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, United States ) , Bakkum-Gamez, Jamie N. (Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, United States ) , Konecny, Gottfried E. (Department of Medicine, Division of Hematology/Oncology, University of California Los Angeles, Los Angeles, CA, United States ) , Weaver, Amy L. (Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States ) , McGree, Michaela E. (Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States ) , Goode, Ellen L. (Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, United States ) , Cliby, William A. (Department of Obstet) , Wang, Chen
    Gynecologic oncology v.147 no.3 ,pp. 503 - 508 , 2017 , 0090-8258 ,

    초록

    Abstract Objective To investigate the association between intraperitoneal (IP) disease dissemination patterns, residual disease (RD), surgical complexity, and molecular subtypes in advanced high-grade serous ovarian cancer (HGSOC). Methods 741 patients with operable stage III-IV HGSOC undergoing primary debulking surgery at Mayo Clinic from 1994 to 2011 were categorized into four mutually exclusive IP disease dissemination patterns: upper abdominal (60%), miliary (16%), lower abdominal (15%), and pelvic (9%). Surgical complexity was classified as high, intermediate, or low; RD status was defined as 0, 0.1–0.5, 0.6–1.0, or >1cm; molecular subtype assignments were derived from expression profiling of tumors from 334 patients. Results Patients with either miliary or upper abdominal dissemination patterns were less likely to achieve RD0 compared to patients with pelvic and lower abdominal dissemination patterns (25% vs. 9% and 62%, each P P P Conclusions IP disease dissemination patterns are associated with RD, surgical complexity, and tumor molecular subtypes. Patients with upper abdominal or miliary dissemination patterns are more likely to have mesenchymal HGSOC and in turn achieve lower rates of complete resection. This provides a plausible model for how the biologic behavior of molecular subtypes is manifest in disease and oncologic outcomes. Highlights Patients with upper abdominal and miliary disease have similar RD0 rates. IP disease dissemination patterns are associated with molecular subtypes. >90% of patients with MES tumors have either upper abdominal or miliary disease. Patients with MES tumor subtype were significantly less likely to achieve RD0.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Tolerance and toxicity of the PARP inhibitor olaparib in older women with epithelial ovarian cancer   SCI SCIE

    Dockery, Lauren E. (University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States ) , Tew, William P. (Memorial Sloan Kettering Cancer Center, New York, NY, United States ) , Ding, Kai (University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States ) , Moore, Kathleen N. (University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States)
    Gynecologic oncology v.147 no.3 ,pp. 509 - 513 , 2017 , 0090-8258 ,

    초록

    Abstract Objectives The objective of this study was to determine the overall tolerability and toxicity of olaparib capsules among older (≥65years) patients with recurrent ovarian cancer treated on 8 completed prospective trials of olaparib. Methods An ancillary data analysis of 398 patients with recurrent ovarian cancer enrolled on eight prospective trials of olaparib capsules was performed. Patients aged 65years and older were stratified into age groups by 5year increments (ages 65–69, 70–74, ≥75years) and compared to those Results Of the 398 patients included, 78 were ≥65 (age 65–69 n = 38, age 70–74 n = 23, age≥75 n = 17). The majority of elderly patients were Caucasian (n=2 Asian) and had received ≥5 prior lines of chemotherapy. In patients p = 0.62). In patients p = 0.11). There were no occurrences of myelodysplastic syndrome or acute myeloid leukemia in any of the older cohorts. Toxicities, including grade 3/4 nausea, were similar across age groups. Conclusions Tolerability and toxicity of olaparib capsules is similar between women ≥65years and Highlights Genetic testing should be offered for epithelial ovarian cancer, irrespective of age No statistical differences in toxicity were observed with olaparib use by age Trends towards more hematologic toxicity were observed with increasing age

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Concomitant venous thromboembolism at the time of primary EOC diagnosis: Perioperative outcomes and survival analyses   SCI SCIE

    Kumar, Amanika (Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, United States ) , Hurtt, Callie C. (Loyola University Medical Center, Chicago, IL, United States ) , Cliby, William A. (Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, United States ) , Martin, Janice R. (Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, United States ) , Weaver, Amy L. (Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States ) , McGree, Michaela E. (Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States ) , Langstraat, Carrie L. (Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, United States ) , Bakkum-Gamez, Jamie N. (Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, United States)
    Gynecologic oncology v.147 no.3 ,pp. 514 - 520 , 2017 , 0090-8258 ,

    초록

    Abstract Objective To compare outcomes among women with epithelial ovarian cancer (EOC) undergoing primary surgery who present without venous thromboembolism (VTE) versus with VTE and placement of inferior vena cava (IVC) filter. Methods Women who underwent primary surgery for EOC between 1/2/2003 and 12/30/2011 were identified. Patient characteristics were retrospectively abstracted, including diagnosis of VTE within 30days prior to surgery and placement of IVC filter. Associations with overall survival (OS) were evaluated using Cox proportional hazards models. Results A total of 843 patients met inclusion criteria; 817 patients (Group 1) did not have VTE at the time of EOC diagnosis and 26 patients (Group 2) had a VTE and IVC placement within 30days prior to surgery. Group 2 had worse performance status, lower albumin, and more likely to have clear cell histology. Groups 1 and 2 were similar in terms of perioperative outcomes. Mortality within 90days of surgery was 6.4% in Group 1 versus 11.5% in Group 2 (p=0.24). Although median OS for group 1 was much higher than group 2, 56.6m versus 25.7m, in this cohort this difference did not reach statistical significance (adjusted HR 1.39, 95% CI 0.85–2.29, p=0.19). Conclusions Patients with VTE diagnosed at the time of EOC diagnosis have poor outcomes. This may reflect more aggressive tumor biology, worse overall health of the patient following VTE, or may reflect worse survival secondary to the VTE. Patients must be carefully selected for surgery in the setting of VTE. Highlights Ovarian cancer surgery in the setting acute VTE is safe with the use of an IVC filter. VTE is associated with clear cell histology, lower functional status and low albumin. VTE diagnosed at time of OS is a poor prognostic factor.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry   SCI SCIE

    Schultz, Kris Ann P. (International Ovarian and Testicular Stromal Tumor Registry, Children's Minnesota, Minneapolis, MN, United States ) , Harris, Anne K. (International Ovarian and Testicular Stromal Tumor Registry, Children's Minnesota, Minneapolis, MN, United States ) , Finch, Michael (Children's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN, United States ) , Dehner, Louis P. (International Ovarian and Testicular Stromal Tumor Registry, Children's Minnesota, Minneapolis, MN, United States ) , Brown, Jubilee B. (Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, United States ) , Gershenson, David M. (Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, United States ) , Young, Robert H. (Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States ) , Field, Amanda (Department of Pathology and Center for Cancer & Immunology Research, Children's National Medical Center, Washington, DC, 20010, United States ) , Yu, Weiying (Department of Pathology and Center for Cancer & Immunology Research, Children's) , Turner, Joyce , Cost, Nicholas G. , Schneider, Dominik T. , Stewart, Douglas R. , Frazier, A. Lindsay , Messinger, Yoav , Hill, D. Ashley
    Gynecologic oncology v.147 no.3 ,pp. 521 - 527 , 2017 , 0090-8258 ,

    초록

    Abstract Background Ovarian sex cord-stromal tumors (OSCST) include juvenile granulosa cell tumors (JGCT), Sertoli-Leydig cell tumor (SLCT) and gynandroblastoma (GAB) among others. These ovarian sex cord-stromal tumors as well as other tumors including pleuropulmonary blastoma (PPB) may be associated with DICER1 mutations. We sought to describe the clinical and genetic findings from the first 107 individuals enrolled in the International Ovarian and Testicular Stromal Tumor Registry. Methods Medical and family history were obtained for individuals consecutively enrolled in the International Ovarian and Testicular Stromal Tumor Registry. Pathology was centrally reviewed. DICER1 sequencing was performed on blood and tumor tissue. Results Of the 107 participants, 49 had SLCT, 25 had JGCT and 5 had GAB. Nearly all (36/37) SLCTs and 4/4 GAB tested had a DICER1 mutation in an RNase IIIb domain hotspot; approximately half of these individuals had a predisposing germline DICER1 mutation. Metachronous SLCTs were seen in 3 individuals with germline DICER1 mutations. Other DICER1 -associated conditions were seen in 19% of patients with SLCT or GAB. Three children of women with SLCT were diagnosed with PPB based on genetic testing and clinical screening during the course of this study. All were diagnosed with PPB in its earliest and most curable form (Type I), were treated with surgery alone, and are alive without evidence of disease. Conclusions Recognition of the distinct genetic basis for a group of these tumors improves precise classification in difficult cases and promotes mutation-based screening and early detection. Highlights DICER1 RNase IIIb mutations were identified in 36/37 SLCT's and 4/4 GABs sequenced. Germline or mosaic mutations were found in more than half of those with SLCT. Predisposing DICER1 mutations were associated with higher recurrence free survival. DICER1 testing in women with SLCT facilitated screening of their children for PPB. Three children were diagnosed with PPB in its earliest and most curable form.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [해외논문]   The impact on survival of two different staging strategies in apparent early stage endometrial cancer comparing sentinel lymph nodes mapping algorithm and selective lymphadenectomy: An Italian retrospective analysis of two reference centers   SCI SCIE

    Buda, Alessandro (Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, ASST-Monza, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy ) , Di Martino, Giampaolo (Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, ASST-Monza, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy ) , Restaino, Stefano (Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, SS Annunziata Hospital, Chieti, Italy ) , De Ponti, Elena (Department of Physical Medicine, ASST-Monza, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy ) , Monterossi, Giorgia (Polo Scienze della Salute della Donna e del Bambino, Fondazione Policlinico Universitario A. Gemelli, Università) , Giuliani, Daniela (Cattolica del Sacro Cuore, Rome, Italy ) , Ercoli, Alfredo (Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, ASST-Monza, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy ) , Dell'Orto, Federica (Department of Obstetrics and Gynecology, Oriental Piedmont University, Maggiore Hospital Novara, Italy ) , Dinoi, Giorgia (Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, ASST-) , Grassi, Tommaso , Scambia, Giovanni , Fanfani, Francesco
    Gynecologic oncology v.147 no.3 ,pp. 528 - 534 , 2017 , 0090-8258 ,

    초록

    Abstract Objective The role of lymphadenectomy in endometrial cancer is still uncertain. We aimed to evaluate the survival outcomes of two different strategies in apparent uterine confined disease by comparing sentinel lymph node (SLN) mapping and selective lymphadenectomy (LD). Methods We retrospectively reviewed women with preoperative stage I endometrial cancer underwent surgical staging with either SLN mapping, or LD in two Italian centers. Results Eight hundred and two women underwent surgical staging for preoperative stage I endometrial cancer were revised (145 Monza; 657 Rome). All patients underwent peritoneal washing, simple hysterectomy with bilateral salpingo-oophorectomy and nodal staging including SLN mapping, or LD. Overall 8229 lymph nodes were removed (1595 in Monza, 6634 in Rome). Pelvic lymphadenectomy was performed in 33.1% and 52.4% in Monza and Rome, respectively (p Conclusions Survival outcomes were similar for both strategies. The SLN strategy allowed to identify a higher rate of stage IIIC1 disease even with a lower median number of lymph node removed in SLN group. Applying a SLN algorithm does not impair the prognosis of endometrial cancer patients. The clinical impact and management of low volume metastasis in high-risk patients should be further clarify. Highlights Impact on survival of two nodal staging strategies in stage I endometrial cancer Sentinel node mapping and selective lymphadenectomy have same survival outcomes. Sentinel node mapping did not impaired prognosis of women with endometrial cancer.

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