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Journal of neuroendocrinology 7건

  1. [해외논문]   Intranasal Insulin Boosts Gustatory Sensitivity   SCI SCIE

    Rodriguez‐ (Diagnostic and Interventional Neuroradiology, University Hospital, RWTH Aachen University, Aachen, Germany) , Raecke, R. (Diagnostic and Interventional Neuroradiology, University Hospital, RWTH Aachen University, Aachen, Germany) , Yang, H. (Diagnostic and Interventional Neuroradiology, University Hospital, RWTH Aachen University, Aachen, Germany) , Bruenner, Y. F. (Diagnostic and Interventional Neuroradiology, University Hospital, RWTH Aachen University, Aachen, Germany) , Freiherr, J.
    Journal of neuroendocrinology v.29 no.1 , 2017 , 0953-8194 ,

    초록

    Intranasal insulin has been the subject of attention not only with respect to enhancing memory processes, but also for its anorexic effects, as well as its effects on olfactory sensitivity. In the present study, the influence of intranasal insulin on gustatory sensitivity was investigated using intranasal applications of insulin or placebo in a double‐blind manner alongside a control condition without any application. We hypothesised that, because it mediates satiety, intranasal insulin alters gustatory sensitivity, whereas placebo application and the control should not alter gustatory sensitivity. We did not expect the sensitivity to the different taste solutions to differ. Sweet, salty, bitter and sour liquids in four concentrations each were sprayed onto the tongue of healthy male subjects. Additionally, water with no taste was applied to enable calculation of taste sensitivity in terms of parameter d′ of signal detection theory. The task of the subject was to identify the quality of the respective tastant. Gustatory sensitivity and blood parameters were evaluated using repeated‐measures ANOVAs. Gustatory sensitivity (implying all tastants) improved significantly after intranasal insulin application compared to the application of placebo, although it did not reach significance compared to the control condition. Subjects performed best when detecting the sweet taste and worst when detecting the bitter taste. The blood parameters glucose, insulin, homeostatic model assessment and leptin did not differ with respect to insulin or placebo condition, nor did they differ regarding measurements preceding or following intranasal application, in confirmation of preserved peripheral euglycaemia during the experiment. Thus, it can be concluded that the application of intranasal insulin led to an improved gustatory sensitivity compared to placebo.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  2. [해외논문]   Incomplete Re‐Expression of Neuroendocrine Progenitor/Stem Cell Markers is a Key Feature of β‐Cell Dedifferentiation   SCI SCIE

    Neelankal John, A. (Harry Perkins Institute of Medical Research, Centre for Medical Research, University of Western Australia, Nedlands, Australia) , Morahan, G. (Harry Perkins Institute of Medical Research, Centre for Medical Research, University of Western Australia, Nedlands, Australia) , Jiang, F.‐ (Harry Perkins Institute of Medical Research, Centre for Medical Research, University of Western Australia, Nedlands, Australia) , X.
    Journal of neuroendocrinology v.29 no.1 , 2017 , 0953-8194 ,

    초록

    There is increasing evidence to suggest that type 2 diabetes mellitus (T2D), a pandemic metabolic disease, may be caused by β‐cell dedifferentiation (βCD). However, there is currently no universal definition of βCD, and the underlying mechanism is poorly understood. We hypothesise that a high‐glucose in vitro environment mimics hyperglycaemia in vivo and that β cells grown in this milieu over a long period will undergo dedifferentiation. In the present study, we report that the pancreatic β cell line mouse insulinoma 6 (MIN6) grown under a high‐glucose condition did not undergo massive cell death but exhibited a glucose‐stimulated insulin‐secreting profile similar to that of immature β cells. The expression of insulin and the glucose‐sensing molecule glucose transporter 2 (Glut2) in late passage MIN6 cells was significantly lower than the early passage at both the RNA and protein levels. Mechanistically, these cells also expressed significantly less of the ‘pancreatic and duodenal homebox1’ (Pdx1) β‐cell transcription factor. Finally, passaged MIN6 cells dedifferentiated to demonstrate some features of β‐cell precursors, as well as neuroendocrine markers, in addition to expressing both glucagon and insulin. Thus, we concluded that high‐glucose passaged MIN6 cells passaged MIN6 cells . provide a cellular model of β‐cell dedifferentiation that can help researchers develop a better understanding of this process. These findings provide new insights that may enhance knowledge of the pathophysiology of T2D and facilitate the establishment of a novel strategy by which this disease can be treated.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Somatostatin Agonist Pasireotide Inhibits Exercise‐Stimulated Growth in the Male Siberian Hamster (Phodopus sungorus)   SCI SCIE

    Dumbell, R. (The Rowett Institute, University of Aberdeen, Aberdeen, UK) , Petri, I. (University of Veterinary Medicine Hannover, Hannover, Germany) , Scherbarth, F. (University of Veterinary Medicine Hannover, Hannover, Germany) , Diedrich, V. (University of Veterinary Medicine Hannover, Hannover, Germany) , Schmid, H. A. (Novartis Pharma AG, Basel, Switzerland) , Steinlechner, S. (University of Veterinary Medicine Hannover, Hannover, Germany) , Barrett, P. (The Rowett Institute, University of Aberdeen, Aberdeen, UK)
    Journal of neuroendocrinology v.29 no.1 , 2017 , 0953-8194 ,

    초록

    The Siberian hamster ( Phodopus sungorus ) is a seasonal mammal, exhibiting a suite of physiologically and behaviourally distinct traits dependent on the time of year and governed by changes in perceived day length (photoperiod). These attributes include significant weight loss, reduced food intake, gonadal atrophy and pelage change with short‐day photoperiod as in winter. The central mechanisms driving seasonal phenotype change during winter are mediated by a reduced availability of hypothalamic triiodothyronine (T3), although the downstream mechanisms responsible for physiological and behavioural changes are yet to be fully clarified. With access to a running wheel (RW) in short photoperiod, Siberian hamsters that have undergone photoperiod‐mediated weight loss over‐ride photoperiod‐drive for reduced body weight and regain weight similar to a hamster held in long days. These changes occur despite retaining the majority of hypothalamic gene expression profiles appropriate for short‐day hamsters. Utilising the somatostatin agonist pasireotide, we recently provided evidence for an involvement of the growth hormone (GH) axis in the seasonal regulation of bodyweight. In the present study, we employed pasireotide to test for the possible involvement of the GH axis in RW‐induced body weight regulation. Pasireotide successfully inhibited exercise‐stimulated growth in short‐day hamsters and this was accompanied by altered hypothalamic gene expression of key GH axis components. Our data provide support for an involvement of the GH axis in the RW response in Siberian hamsters.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Pituitary Stalk Interruption Syndrome: From Clinical Findings to Pathogenesis   SCI SCIE

    Wang, C.‐ (Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100853, China) , Z. (Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100853, China) , Guo, L.‐ (Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100853, China) , L. (Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100853, China) , Han, B.‐ (Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100853, China) , Y. (Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100853, China) , Su, X. , Guo, Q.‐ , H. , Mu, Y.‐ , M.
    Journal of neuroendocrinology v.29 no.1 , 2017 , 0953-8194 ,

    초록

    Pituitary stalk interruption syndrome (PSIS) is a rare congenital defect manifesting with varying degrees of pituitary hormone deficiency. The signs and symptoms of PSIS during the neonatal period and infancy are often overlooked and therefore diagnosis is delayed. The typical manifestations of PSIS can be detected by magnetic resonance imaging. Several genes in the Wnt, Notch and Shh signalling pathways related to hypothalamic‐pituitary development, such as PIT1 , PROP1 , LHX3/LHX4 , PROKR2 , OTX2 , TGIF and HESX1 , have been found to be associated with PSIS. Nevertheless, the aetiology in the majority of cases still remains unknown. In the present review, we provide an overview of clinical features of PSIS and summarise our current understanding of the underlying pathogenic mechanisms for this rare syndrome. Furthermore, we propose future research directions that may help our understanding of the aetiology of PSIS.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Mild Thyrotoxicosis Leads to Brain Perfusion Changes: An Arterial Spin Labelling Study   SCI SCIE

    Gö (Department of Neurology, University of Lübeck, Lübeck, Germany) , bel, A. (Department of Neurology, University of Lübeck, Lübeck, Germany) , Heldmann, M. (Central Institute of Mental Health, Mannheim, Germany) , Sartorius, A. (Department of Neurology, University of Lübeck, Lübeck, Germany) , Gö (Department of Internal Medicine I, University of Lübeck, Lübeck, Germany) , ttlich, M. (Department of Internal Medicine I, University of Lübeck, Lübeck, Germany) , Dirk, A.‐ (Department of Neurology, University of Lübeck, Lübeck, Germany) , L. , Brabant, G. , Mü , nte, T. F.
    Journal of neuroendocrinology v.29 no.1 , 2017 , 0953-8194 ,

    초록

    Hypo‐ and hyperthyroidism have effects on brain structure and function, as well as cognitive processes, including memory. However, little is known about the influence of thyroid hormones on brain perfusion and the relationship of such perfusion changes with cognition. The present study aimed to demonstrate the effect of short‐term experimental hyperthyroidism on brain perfusion in healthy volunteers and to assess whether perfusion changes, if present, are related to cognitive performance. It is known that an interaction exists between brain perfusion and cerebral oxygen consumption rate and it is considered that neural activation increases cerebral regional perfusion rate in brain areas associated with memory. Measuring cerebral blood flow may therefore represent a proxy for neural activity. Therefore, arterial spin labelling (ASL) measurements were conducted and later analysed to evaluate brain perfusion in 29 healthy men before and after ingesting thyroid hormones for 8 weeks. Psychological tests concerning memory were performed at the same time‐points and the results were correlated with the imaging results. In the hyperthyroid condition, perfusion was increased in the posterior cerebellum in regions connected with cerebral networks associated with cognitive control and the visual cortex compared to the euthyroid condition. In addition, these perfusion changes were positively correlated with changes of performance in the German version of the Auditory Verbal Learning Task [AVLT, Verbaler Lern‐und‐MerkfAhigkeits‐Test (VLMT)]. Cerebellar perfusion and function therefore appears to be modulated by thyroid hormones, likely because the cerebellum hosts a high number of thyroid hormone receptors.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Issue Information   SCI SCIE


    Journal of neuroendocrinology v.29 no.1 , 2017 , 0953-8194 ,

    초록

    Hypo‐ and hyperthyroidism have effects on brain structure and function, as well as cognitive processes, including memory. However, little is known about the influence of thyroid hormones on brain perfusion and the relationship of such perfusion changes with cognition. The present study aimed to demonstrate the effect of short‐term experimental hyperthyroidism on brain perfusion in healthy volunteers and to assess whether perfusion changes, if present, are related to cognitive performance. It is known that an interaction exists between brain perfusion and cerebral oxygen consumption rate and it is considered that neural activation increases cerebral regional perfusion rate in brain areas associated with memory. Measuring cerebral blood flow may therefore represent a proxy for neural activity. Therefore, arterial spin labelling (ASL) measurements were conducted and later analysed to evaluate brain perfusion in 29 healthy men before and after ingesting thyroid hormones for 8 weeks. Psychological tests concerning memory were performed at the same time‐points and the results were correlated with the imaging results. In the hyperthyroid condition, perfusion was increased in the posterior cerebellum in regions connected with cerebral networks associated with cognitive control and the visual cortex compared to the euthyroid condition. In addition, these perfusion changes were positively correlated with changes of performance in the German version of the Auditory Verbal Learning Task [AVLT, Verbaler Lern‐und‐MerkfAhigkeits‐Test (VLMT)]. Cerebellar perfusion and function therefore appears to be modulated by thyroid hormones, likely because the cerebellum hosts a high number of thyroid hormone receptors.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Forebrain‐Specific Transgene Rescue of 11β‐HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain‐Derived Neurotrophic Factor mRNA Levels in Aged 11β‐HSD1 Deficient Mice   SCI SCIE

    Caughey, S. (UoE/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK) , Harris, A. P. (UoE/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK) , Seckl, J. R. (UoE/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK) , Holmes, M. C. (UoE/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK) , Yau, J. L. W. (UoE/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK)
    Journal of neuroendocrinology v.29 no.1 , 2017 , 0953-8194 ,

    초록

    Mice lacking the intracellular glucocorticoid‐regenerating enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) are protected from age‐related spatial memory deficits. 11β‐HSD1 is expressed predominantly in the brain, liver and adipose tissue. Reduced glucocorticoid levels in the brain in the absence of 11β‐HSD1 may underlie the improved memory in aged 11β‐HSD1 deficient mice. However, the improved glucose tolerance, insulin sensitisation and cardioprotective lipid profile associated with reduced peripheral glucocorticoid regeneration may potentially contribute to the cognitive phenotype of aged 11β‐HSD1 deficient mice. In the present study, transgenic mice with forebrain‐specific overexpression of 11β‐HSD1 (Tg) were intercrossed with global 11β‐HSD1 knockout mice (HSD1KO) to examine the influence of forebrain and peripheral 11β‐HSD1 activity on spatial memory in aged mice. Transgene‐mediated delivery of 11β‐HSD1 to the hippocampus and cortex of aged HSD1KO mice reversed the improved spatial memory retention in the Y‐maze but not spatial learning in the watermaze. Brain‐derived neurotrophic factor (BDNF) mRNA levels in the hippocampus of aged HSD1KO mice were increased compared to aged wild‐type mice. Rescue of forebrain 11β‐HSD1 reduced BDNF mRNA in aged HSD1KO mice to levels comparable to aged wild‐type mice. These findings indicate that 11β‐HSD1 regenerated glucocorticoids in the forebrain and decreased levels of BDNF mRNA in the hippocampus play a role in spatial memory deficits in aged wild‐type mice, although 11β‐HSD1 activity in peripheral tissues may also contribute to spatial learning impairments in aged mice.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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