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Gut: journal of the British Society of Gastroenter...Gut: journal of the British Society of Gastroenterology 27건

  1. [해외논문]   Ethics and hepatitis B cure research   SCI SCIE

    Sugarman, Jeremy (Berman Institute of Bioethics, Johns Hopkins University, , Baltimore, Maryland, USA ) , Revill, Peter (Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, , Melbourne, Australia ) , Zoulim, Fabien (INSERM, Cancer Research Center of Lyon, Hospices Civils de Lyon, Lyon University, , Lyon, France ) , Yazdanpanah, Yazdan (INSERM, Infection Antimicrobials Modelling Evolution, University of Paris Diderot, Hôpital Bichat, , Paris, France ) , Janssen, Harry L A (Toronto Centre for Liver Disease, University Health Network, Toronto General Hospital, , Toronto, Canada ) , Lim, Seng Gee (Division of Gastroenterology and Hepatology, National University Health System, , Singapore, Singapore ) , Lewin, Sharon R (The Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, , Melbourne, Australia)
    Gut: journal of the British Society of Gastroenterology v.66 no.3 ,pp. 389 - 392 , 2017 , 0017-5749 ,

    초록

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   Building pancreatic organoids to aid drug development   SCI SCIE

    Wills, Edgar S (Department of Gastroenterology and Hepatology, Radboud University Medical Center, , Nijmegen, The Netherlands ) , Drenth, Joost P H (Department of Gastroenterology and Hepatology, Radboud University Medical Center, , Nijmegen, The Netherlands)
    Gut: journal of the British Society of Gastroenterology v.66 no.3 ,pp. 393 - 394 , 2017 , 0017-5749 ,

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Preventing disease relapses in autoimmune pancreatitis with maintenance steroids: are we there yet?   SCI SCIE

    Hart, Phil A (Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, , Columbus, Ohio, USA ) , Chari, Suresh T (Division of Gastroenterology and Hepatology, Mayo Clinic, , Rochester, Minnesota, USA)
    Gut: journal of the British Society of Gastroenterology v.66 no.3 ,pp. 394 - 396 , 2017 , 0017-5749 ,

    초록

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Gut microbiota and Toll-like receptors set the stage for cytokine-mediated failure of antibacterial responses in the fibrotic liver   SCI SCIE

    Kuntzen, Christian (Department of Medicine, Columbia University, , New York, New York, USA ) , Schwabe, Robert F (Department of Medicine, Columbia University, , New York, New York, USA)
    Gut: journal of the British Society of Gastroenterology v.66 no.3 ,pp. 396 - 398 , 2017 , 0017-5749 ,

    초록

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   The prognostic value of TP53 mutations in oesophageal adenocarcinoma: a systematic review and meta-analysis   SCI SCIE

    Fisher, Oliver M (Gastroesophageal Cancer Program, St Vincent's Centre for Applied Medical Research University of New South Wales, , Sydney, New South Wales, Australia ) , Lord, Sarah J (Gastroesophageal Cancer Program, St Vincent's Centre for Applied Medical Research University of New South Wales, , Sydney, New South Wales, Australia ) , Falkenback, Dan (Gastroesophageal Cancer Program, St Vincent's Centre for Applied Medical Research University of New South Wales, , Sydney, New South Wales, Australia ) , Clemons, Nicholas J (Cancer Biology and Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, , Melbourne, Victoria, Australia ) , Eslick, Guy D (The Whiteley-Martin Research Centre, Discipline of Surgery, The University of Sydney, , Sydney, New South Wales, Australia ) , Lord, Reginald V (Gastroesophageal Cancer Program, St Vincent's Centre for Applied Medical Research University of New South Wales, , Sydney, New South Wales, Australia)
    Gut: journal of the British Society of Gastroenterology v.66 no.3 ,pp. 399 - 410 , 2017 , 0017-5749 ,

    초록

    Objective To clarify the prognostic role of tumour protein 53 (TP53) mutations in patients with oesophageal adenocarcinoma (OAC) as there is a need for biomarkers that assist in guiding management for patients with OAC. Design A systematic review was conducted using MEDLINE, Embase, PubMed and Current Contents Connect to identify studies published between January 1990 and February 2015 of oesophageal cancer populations (with OAC diagnoses >50% of cases) that measured tumoural TP53 status and reported hazard ratios (HR), or adequate data for estimation of HR for survival for TP53-defined subgroups. Risk of bias for HR estimates was assessed using prespecified criteria for the appraisal of relevant domains as defined by the Cochrane Prognosis Methods Group including adherence to Grading of Recommendations, Assessment, Development and Evaluation and REporting recommendations for tumor MARKer prognostic studies guidelines, as well as assay method used (direct TP53 mutation assessment vs immunohistochemistry) and adjustment for standard prognostic factors. A pooled HR and 95% CI were calculated using a random-effects model. Results Sixteen eligible studies (11 with OAC only and 5 mixed histology cohorts) including 888 patients were identified. TP53 mutations were associated with reduced survival (HR 1.48, 95% CI 1.16 to 1.90, I 2 = 33%). A greater prognostic effect was observed in a sensitivity analysis of those studies that reported survival for OAC-only cohorts and were assessed at low risk of bias (HR 2.11, 95% CI 1.35 to 3.31, I 2 = 0%). Conclusions Patients with OAC and TP53 gene mutations have reduced overall survival compared with patients without these mutations, and this effect is independent of tumour stage.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Efficacy of psychotropic drugs in functional dyspepsia: systematic review and meta-analysis   SCI SCIE

    Ford, Alexander C (Leeds Gastroenterology Institute, St. James's University Hospital, , Leeds, UK ) , Luthra, Pavit (Leeds Gastroenterology Institute, St. James's University Hospital, , Leeds, UK ) , Tack, Jan (Translational Research Center for Gastrointestinal Disorders (TARGID), University Hospital Leuven, Catholic University Leuven, , Leuven, Belgium ) , Boeckxstaens, Guy E (Translational Research Center for Gastrointestinal Disorders (TARGID), University Hospital Leuven, Catholic University Leuven, , Leuven, Belgium ) , Moayyedi, Paul (Gastroenterology Division, McMaster University, , Health Sciences Center, Hamilton, Ontario, Canada ) , Talley, Nicholas J (Faculty of Health, University of Newcastle, , Callaghan, New South Wales, Australia)
    Gut: journal of the British Society of Gastroenterology v.66 no.3 ,pp. 411 - 420 , 2017 , 0017-5749 ,

    초록

    Objective Functional dyspepsia (FD) is a chronic gastroduodenal disorder. Individuals with FD demonstrate visceral hypersensitivity, abnormal central pain processing, and low mood, but it is unclear whether psychotropic drugs are an effective treatment for the condition. We performed a systematic review and meta-analysis of randomised controlled trials (RCTs). Design MEDLINE, EMBASE, EMBASE Classic, PsychINFO and the Cochrane Controlled Trials Register were searched (up to June 2015) for RCTs recruiting adults with FD comparing psychotropic drugs with placebo. We contacted authors directly to maximise trial eligibility and minimise risk of bias for studies. Dichotomous symptom data were pooled to obtain relative risk (RR) of remaining symptomatic after therapy, with 95% CIs. Results The search identified 2795 citations; 13 RCTs (1241 patients) were eligible. Ten trials were at low risk of bias. The RR of FD symptoms not improving with psychotropic drugs versus placebo was 0.78 (95% CI 0.68 to 0.91) (number needed to treat=6; 95% CI 4 to 16). However, benefit was limited to antipsychotics and tricyclic antidepressants. When only studies that excluded individuals with coexistent mood disorder were considered, there was no benefit. Total numbers of adverse events and adverse events leading to withdrawal were significantly more common, with a number needed to harm of 21 for both. Conclusions Psychotropic drugs may be an effective treatment for FD, but the effect appears to be limited to antipsychotics and tricyclic antidepressants with fewer trials for other agents, meaning that firm conclusions for efficacy cannot be made. More data from high quality RCTs are required to support their use in the treatment of FD.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis   SCI SCIE

    Westerlind, Helga (Institute of Environmental Medicine, Karolinska Institutet, , Stockholm, Sweden ) , Mellander, Marie-Rose (Department of Medicine Solna, Karolinska Institutet, , Stockholm, Sweden ) , Bresso, Francesca (Department of Biosciences and Nutrition, Karolinska Institutet, , Stockholm, Sweden ) , Munch, Andreas (Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkopings University, , Linkoping, Sweden ) , Bonfiglio, Ferdinando (Department of Biosciences and Nutrition, Karolinska Institutet, , Stockholm, Sweden ) , Assadi, Ghazaleh (Department of Biosciences and Nutrition, Karolinska Institutet, , Stockholm, Sweden ) , Rafter, Joseph (Department of Biosciences and Nutrition, Karolinska Institutet, , Stockholm, Sweden ) , Hubenthal, Matthias (Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, , Kiel, Germany ) , Lieb, Wolfgang (Institute of Epidemiology and Biobank POPGEN, Christian-Albrechts-University of Kiel, , Kiel, Germany ) , Kallberg, Henrik (Institute of Environmental Medicine, Karolinska Institutet, , Stockholm, Sweden ) , Brynedal, Boel (Institute of Environmental Medicine, Karolinska Institutet, , Stockholm, Sweden ) , Padyukov, Leonid (Department) , Halfvarson, Jonas , Torkvist, Leif , Bjork, Jan , Andreasson, Anna , Agreus, Lars , Almer, Sven , Miehlke, Stephan , Madisch, Ahmed , Ohlsson, Bodil , Lofberg, Robert , Hultcrantz, Rolf , Franke, Andre , D'Amato, Mauro
    Gut: journal of the British Society of Gastroenterology v.66 no.3 ,pp. 421 - 428 , 2017 , 0017-5749 ,

    초록

    Objective Collagenous colitis (CC) is a major cause of chronic non-bloody diarrhoea, particularly in the elderly female population. The aetiology of CC is unknown, and still poor is the understanding of its pathogenesis. This possibly involves dysregulated inflammation and immune-mediated reactions in genetically predisposed individuals, but the contribution of genetic factors to CC is underinvestigated. We systematically tested immune-related genes known to impact the risk of several autoimmune diseases for their potential CC-predisposing role. Design Three independent cohorts of histologically confirmed CC cases (N=314) and controls (N=4299) from Sweden and Germany were included in a 2-step association analysis. Immunochip and targeted single nucleotide polymorphism (SNP) genotype data were produced, respectively, for discovery and replication purposes. Classical human leucocyte antigen (HLA) variants at 2-digit and 4-digit resolution were obtained via imputation from single marker genotypes. SNPs and HLA variants passing quality control filters were tested for association with CC with logistic regression adjusting for age, sex and country of origin. Results Forty-two markers gave rise to genome-wide significant association signals, all contained within the HLA region on chromosome 6 (best p=4.2×10 −10 for SNP rs4143332). Among the HLA variants, most pronounced risk effects were observed for 8.1 haplotype alleles including DQ2.5, which was targeted and confirmed in the replication data set (p=2.3×10 −11 ; OR=2.06; 95% CI (1.67 to 2.55) in the combined analysis). Conclusions HLA genotype associates with CC, thus implicating HLA-related immune mechanisms in its pathogenesis.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Microbiota-induced obesity requires farnesoid X receptor   SCI SCIE

    Parsé (University of Gothenburg ) , us, Ava (University of Gothenburg ) , Sommer, Nina (University of Gothenburg ) , Sommer, Felix (University of Gothenburg ) , Caesar, Robert (University of Gothenburg ) , Molinaro, Antonio (University of Gothenburg ) , Stå (University of Gothenburg ) , hlman, Marcus (University of Gothenburg ) , Greiner, Thomas U (University of Gothenburg ) , Perkins, Rosie , Bä , ckhed, Fredrik
    Gut: journal of the British Society of Gastroenterology v.66 no.3 ,pp. 429 - 437 , 2017 , 0017-5749 ,

    초록

    Objective The gut microbiota has been implicated as an environmental factor that modulates obesity, and recent evidence suggests that microbiota-mediated changes in bile acid profiles and signalling through the bile acid nuclear receptor farnesoid X receptor (FXR) contribute to impaired host metabolism. Here we investigated if the gut microbiota modulates obesity and associated phenotypes through FXR. Design We fed germ-free (GF) and conventionally raised (CONV-R) wild-type and Fxr−/− mice a high-fat diet (HFD) for 10 weeks. We monitored weight gain and glucose metabolism and analysed the gut microbiota and bile acid composition, beta-cell mass, accumulation of macrophages in adipose tissue, liver steatosis, and expression of target genes in adipose tissue and liver. We also transferred the microbiota of wild-type and Fxr -deficient mice to GF wild-type mice. Results The gut microbiota promoted weight gain and hepatic steatosis in an FXR-dependent manner, and the bile acid profiles and composition of faecal microbiota differed between Fxr−/− and wild-type mice. The obese phenotype in colonised wild-type mice was associated with increased beta-cell mass, increased adipose inflammation, increased steatosis and expression of genes involved in lipid uptake. By transferring the caecal microbiota from HFD-fed Fxr−/− and wild-type mice into GF mice, we showed that the obesity phenotype was transferable. Conclusions Our results indicate that the gut microbiota promotes diet-induced obesity and associated phenotypes through FXR, and that FXR may contribute to increased adiposity by altering the microbiota composition.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Adenoma detection with Endocuff colonoscopy versus conventional colonoscopy: a multicentre randomised controlled trial   SCI SCIE

    van Doorn, SC (Departments of Gastroenterology & Hepatology, Academic Medical Centre, University of Amsterdam, , Amsterdam, The Netherlands ) , van der Vlugt, M (Departments of Gastroenterology & Hepatology, Academic Medical Centre, University of Amsterdam, , Amsterdam, The Netherlands ) , Depla, ACTM (Departments of Gastroenterology & Hepatology, Slotervaartziekenhuis, , Amsterdam, The Netherlands ) , Wientjes, CA (Departments of Gastroenterology & Hepatology, Sint Lucas Andreas Ziekenhuis, , Amsterdam, The Netherlands ) , Mallant-Hent, RC (Departments of Gastroenterology & Hepatology, Flevoziekenhuis, , Almere, The Netherlands ) , Siersema, PD (Departments of Gastroenterology & Hepatology, University Medical Centre Utrecht, , Utrecht, The Netherlands ) , Tytgat, KMAJ (Departments of Gastroenterology & Hepatology, Academic Medical Centre, University of Amsterdam, , Amsterdam, The Netherlands ) , Tuynman, H (Departments of Gastroenterology & Hepatology, Sint Lucas Andreas Ziekenhuis, , Amsterdam, The Netherlands ) , Kuiken, SD (Departments of Gastroenterology & Hepatology, Slotervaartziekenhuis, , Amsterdam, The Netherlands ) , Houben, GMP (De) , Stokkers, PCF , Moons, LMG , Bossuyt, PMM , Fockens, P , Mundt, MW , Dekker, E
    Gut: journal of the British Society of Gastroenterology v.66 no.3 ,pp. 438 - 445 , 2017 , 0017-5749 ,

    초록

    Background and aims Colonoscopy is the current reference standard for the detection of colorectal neoplasia, but nevertheless adenomas remain undetected. The Endocuff, an endoscopic cap with plastic projections, may improve colonic visualisation and adenoma detection. The aim of this study was to compare the mean number of adenomas per patient (MAP) and the adenoma detection rate (ADR) between Endocuff-assisted colonoscopy (EAC) and conventional colonoscopy (CC). Methods We performed a multicentre, randomised controlled trial in five hospitals and included fecal immonochemical test (FIT)-positive screening participants as well as symptomatic patients (>45 years). Consenting patients were randomised 1:1 to EAC or CC. All colonoscopies were performed by experienced colonoscopists (≥500 colonoscopies) who were trained in EAC. All colonoscopy quality indicators were prospectively recorded. Findings Of the 1063 included patients (52% male, median age 65 years), 530 were allocated to EAC and 533 to CC. More adenomas were detected with EAC, 722 vs 621, but the gain in MAP was not significant: on average 1.36 per patient in the EAC group versus 1.17 in the CC group (p=0.08). In a per-protocol analysis, the gain was 1.44 vs 1.19 (p=0.02), respectively. In the EAC group, 275 patients (52%) had one or more adenomas detected versus 278 in the CC group (52%; p=0.92). For advanced adenomas these numbers were 109 (21%) vs 117 (22%). The adjusted caecal intubation rate was lower with EAC (94% vs 99%; p<0.001), however when allowing crossover from EAC to CC, they were similar in both groups (98% vs 99%; p value=0.25). Interpretation Though more adenomas are detected with EAC, the routine use of Endocuff does not translate in a higher number of patients with one or more adenomas detected. Whether increased detection ultimately results in a lower rate of interval carcinomas is not yet known. Trial registration number http://www.trialregister.nl Dutch Trial Register: NTR3962.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [해외논문]   Risk stratification of individuals with low-risk colorectal adenomas using clinical characteristics: a pooled analysis   SCI SCIE

    Gupta, Samir (Department of Medicine, Section of Gastroenterology, Veteran Affairs San Diego Healthcare System, , San Diego, California, USA ) , Jacobs, Elizabeth T (Department of Epidemiology and Biostatistics, Arizona Cancer Center, Arizona College of Public Health, University of Arizona, , Tucson, Arizona, USA ) , Baron, John A (Department of Medicine, University of North Carolina School of Medicine, , Chapel Hill, North Carolina, USA ) , Lieberman, David A (Division of Gastroenterology and Hepatology, Portland Veterans Affairs Medical Cente and Oregon Health and Science University, , Portland, Oregon, USA ) , Murphy, Gwen (Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, , Bethesda, Maryland, USA ) , Ladabaum, Uri (Division of Gastroenterology/Hepatology, Department of Medicine, Stanford University School of Medicine, , Stanford, California, USA ) , Cross, Amanda J (Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, , Rockville, Maryland, USA ) , Jover, Rodrigo (Unidad de Gastro) , Liu, Lin , Martinez, Maria Elena
    Gut: journal of the British Society of Gastroenterology v.66 no.3 ,pp. 446 - 453 , 2017 , 0017-5749 ,

    초록

    Objective For individuals with 1–2 small (<1 cm) low-risk colorectal adenomas, international guidelines range from no surveillance to offering surveillance colonoscopy in 5–10 years. We hypothesised that the risks for metachronous advanced neoplasia (AN) among patients with low-risk adenomas differ based on clinical factors distinct from those currently used. Design We pooled data from seven prospective studies to assess the risk of metachronous AN. Two groups with 1–2 small adenomas were defined based on guidelines from the UK (n=4516) or the European Union (EU)/US (n=2477). Results Absolute risk of metachronous AN ranged from a low of 2.9% to a high of 12.2%, depending on specific risk factor and guideline used. For the UK group, the highest absolute risks for metachronous AN were found among individuals with a history of prior polyp (12.2%), villous histology (12.2%), age ≥70 years (10.9%), high-grade dysplasia (10.9%), any proximal adenoma (10.2%), distal and proximal adenoma (10.8%) or two adenomas (10.1%). For the EU/US group, the highest absolute risks for metachronous AN were among individuals with a history of prior polyp (11.5%) or the presence of both proximal and distal adenomas (11.0%). In multivariate analyses, strong associations for increasing age and history of prior polyps and odds of metachronous AN were observed, whereas more modest associations were shown for baseline proximal adenomas and those with villous features. Conclusions Risks of metachronous AN among individuals with 1–2 small adenomas vary according to readily available clinical characteristics. These characteristics may be considered for recommending colonoscopy surveillance and require further investigation.

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