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Cell 35건

  1. [해외논문]   There Will Be Blood Tests   SCI SCIE

    Dodgson, Stacie E.
    Cell v.173 no.1 ,pp. 1 - 1 , 2018 , 0092-8674 ,

    초록

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  2. [해외논문]   Gene Therapy for Retinal Degeneration   SCI SCIE

    Apte, Rajendra S. (Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, St. Louis, MO 63110, USA)
    Cell v.173 no.1 ,pp. 5 - 5 , 2018 , 0092-8674 ,

    초록

    Summary Biallelic mutations in the RPE65 gene are associated with inherited retinal degenerations/dystrophies (IRD) and disrupt the visual cycle, leading to loss of vision. A new adenoviral vector-based gene therapy surgically delivered to retinal cells provides normal human RPE65 protein that can restore the visual cycle and some vision. To view this Bench to Bedside, open or download the PDF.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   The Predecessors Within . . .   SCI SCIE

    Vernot, Benjamin (Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany ) , Pä (Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany) , ä , bo, Svante
    Cell v.173 no.1 ,pp. 6 - 7 , 2018 , 0092-8674 ,

    초록

    By examining the genomes of present-day people from Asia, researchers show that modern humans met and interbred with Denisovans, distant relatives to Neanderthals, on at least two occasions. As a result, people today carry DNA from two different Denisovan populations.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   H2S to Mitigate Vascular Aging: A SIRT1 Connection   SCI SCIE

    Arumugam, Thiruma V. (Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, 2 Medical Drive, Singapore 117593, Singapore ) , Kennedy, Brian K. (Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, 2 Medical Drive, Singapore 117593, Singapore)
    Cell v.173 no.1 ,pp. 8 - 10 , 2018 , 0092-8674 ,

    초록

    H 2 S is an endogenous gasotransmitter that plays an important role in physiological conditions. In this issue, Das et al. provide evidence that SIRT1-dependent angiogenesis is augmented by H 2 S—findings reinforced by Longchamp et al., who demonstrate that H 2 S-dependent angiogenesis is triggered by amino acid deprivation.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Opportunities and Challenges in Building a Spatiotemporal Multi-scale Model of the Human Pancreatic β Cell   SCI SCIE

    Singla, Jitin (Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA ) , McClary, Kyle M. (Department of Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA ) , White, Kate L. (Department of Biological Sciences, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA ) , Alber, Frank (Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA ) , Sali, Andrej (California Institute for Quantitative Biosciences, Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA ) , Stevens, Raymond C. (Department of Biological Sciences, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA)
    Cell v.173 no.1 ,pp. 11 - 19 , 2018 , 0092-8674 ,

    초록

    The construction of a predictive model of an entire eukaryotic cell that describes its dynamic structure from atomic to cellular scales is a grand challenge at the intersection of biology, chemistry, physics, and computer science. Having such a model will open new dimensions in biological research and accelerate healthcare advancements. Developing the necessary experimental and modeling methods presents abundant opportunities for a community effort to realize this goal. Here, we present a vision for creation of a spatiotemporal multi-scale model of the pancreatic β–cell, a relevant target for understanding and modulating the pathogenesis of diabetes.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Metazoan MicroRNAs   SCI SCIE

    Bartel, David P. (Howard Hughes Medical Institute and Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA)
    Cell v.173 no.1 ,pp. 20 - 51 , 2018 , 0092-8674 ,

    초록

    MicroRNAs (miRNAs) are ∼22 nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs help sculpt the expression of most mRNAs. This article reviews advances in our understanding of the defining features of metazoan miRNAs and their biogenesis, genomics, and evolution. It then reviews how metazoan miRNAs are regulated, how they recognize and cause repression of their targets, and the biological functions of this repression, with a compilation of knockout phenotypes that shows that important biological functions have been identified for most of the broadly conserved miRNAs of mammals.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture  

    Browning, Sharon R. , Browning, Brian L. , Zhou, Ying , Tucci, Serena , Akey, Joshua M.
    Cell v.173 no.1 ,pp. 53 - 61.e9 , 2018 , 0092-8674 ,

    초록

    MicroRNAs (miRNAs) are ∼22 nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs help sculpt the expression of most mRNAs. This article reviews advances in our understanding of the defining features of metazoan miRNAs and their biogenesis, genomics, and evolution. It then reviews how metazoan miRNAs are regulated, how they recognize and cause repression of their targets, and the biological functions of this repression, with a compilation of knockout phenotypes that shows that important biological functions have been identified for most of the broadly conserved miRNAs of mammals.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture   SCI SCIE

    Browning, Sharon R. (Department of Biostatistics, University of Washington, Seattle, WA 98195, USA ) , Browning, Brian L. (Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA ) , Zhou, Ying (Department of Biostatistics, University of Washington, Seattle, WA 98195, USA ) , Tucci, Serena (Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA ) , Akey, Joshua M. (Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA)
    Cell v.173 no.1 ,pp. 53 - 61.e9 , 2018 , 0092-8674 ,

    초록

    Summary Anatomically modern humans interbred with Neanderthals and with a related archaic population known as Denisovans. Genomes of several Neanderthals and one Denisovan have been sequenced, and these reference genomes have been used to detect introgressed genetic material in present-day human genomes. Segments of introgression also can be detected without use of reference genomes, and doing so can be advantageous for finding introgressed segments that are less closely related to the sequenced archaic genomes. We apply a new reference-free method for detecting archaic introgression to 5,639 whole-genome sequences from Eurasia and Oceania. We find Denisovan ancestry in populations from East and South Asia and Papuans. Denisovan ancestry comprises two components with differing similarity to the sequenced Altai Denisovan individual. This indicates that at least two distinct instances of Denisovan admixture into modern humans occurred, involving Denisovan populations that had different levels of relatedness to the sequenced Altai Denisovan. Video Abstract Display Omitted Highlights Asian genomes carry introgressed DNA from Denisovans and Neanderthals East Asians show evidence of introgression from two distinct Denisovan populations South Asians and Oceanians carry introgression from one Denisovan population Graphical Abstract [DISPLAY OMISSION]

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity   SCI SCIE

    Kayatekin, Can (Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA ) , Amasino, Audra (Massachusetts Institute of Technology, Cambridge, MA 02142, USA ) , Gaglia, Giorgio (Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA ) , Flannick, Jason (Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA ) , Bonner, Julia M. (Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA ) , Fanning, Saranna (Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA ) , Narayan, Priyanka (Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA ) , Barrasa, M. Inmaculada (Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA ) , Pincus, David (Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA ) , Landgraf, Dirk (Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA ) , Nelson, Justin (Bioinformatics and Computational Biology Graduate Program, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA ) , Hesse, William R. (Massachusetts Institute of Technology, Cambridge, MA 02142, USA ) , Costanzo, Michael (Donnelly Centre, University of Toronto, Toro) , Myers, Chad L. , Boone, Charles , Florez, Jose C. , Lindquist, Susan
    Cell v.173 no.1 ,pp. 62 - 73.e9 , 2018 , 0092-8674 ,

    초록

    Summary Aggregates of human islet amyloid polypeptide (IAPP) in the pancreas of patients with type 2 diabetes (T2D) are thought to contribute to β cell dysfunction and death. To understand how IAPP harms cells and how this might be overcome, we created a yeast model of IAPP toxicity. Ste24, an evolutionarily conserved protease that was recently reported to degrade peptides stuck within the translocon between the cytoplasm and the endoplasmic reticulum, was the strongest suppressor of IAPP toxicity. By testing variants of the human homolog, ZMPSTE24, with varying activity levels, the rescue of IAPP toxicity proved to be directly proportional to the declogging efficiency. Clinically relevant ZMPSTE24 variants identified in the largest database of exomes sequences derived from T2D patients were characterized using the yeast model, revealing 14 partial loss-of-function variants, which were enriched among diabetes patients over 2-fold. Thus, clogging of the translocon by IAPP oligomers may contribute to β cell failure. Highlights Developed a yeast model of IAPP proteotoxicity IAPP oligomers clogged the ER-to-cytoplasm translocon Genetic screens identified STE24/ZMPSTE24 as a strong suppressor of IAPP proteotoxicity Loss-of-function mutations in ZMPSTE24 were more often found in diabetes patients Graphical Abstract [DISPLAY OMISSION]

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [해외논문]   Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging   SCI SCIE

    Das, Abhirup (Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA ) , Huang, George X. (Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA ) , Bonkowski, Michael S. (Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA ) , Longchamp, Alban (Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA ) , Li, Catherine (Laboratory for Ageing Research, Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia ) , Schultz, Michael B. (Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA ) , Kim, Lynn-Jee (Laboratory for Ageing Research, Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia ) , Osborne, Brenna (Mitochondrial Bioenergetics Laboratory, Department of Ph) , Joshi, Sanket , Lu, Yuancheng , Treviñ , o-Villarreal, Jose Humberto , Kang, Myung-Jin , Hung, Tzong-tyng , Lee, Brendan , Williams, Eric O. , Igarashi, Masaki , Mitchell, James R. , Wu, Lindsay E. , Turner, Nigel , Arany, Zolt , Guarente, Leonard , Sinclair, David A.
    Cell v.173 no.1 ,pp. 74 - 89.e20 , 2018 , 0092-8674 ,

    초록

    Summary A decline in capillary density and blood flow with age is a major cause of mortality and morbidity. Understanding why this occurs is key to future gains in human health. NAD precursors reverse aspects of aging, in part, by activating sirtuin deacylases (SIRT1–SIRT7) that mediate the benefits of exercise and dietary restriction (DR). We show that SIRT1 in endothelial cells is a key mediator of pro-angiogenic signals secreted from myocytes. Treatment of mice with the NAD + booster nicotinamide mononucleotide (NMN) improves blood flow and increases endurance in elderly mice by promoting SIRT1-dependent increases in capillary density, an effect augmented by exercise or increasing the levels of hydrogen sulfide (H 2 S), a DR mimetic and regulator of endothelial NAD + levels. These findings have implications for improving blood flow to organs and tissues, increasing human performance, and reestablishing a virtuous cycle of mobility in the elderly. Highlights Reduced blood flow with age is due to loss of endothelial NAD + -SIRT1 activity NAD + and H 2 S control muscle angiogenesis and increase endurance in old mice The NAD precursor NMN mimics and augments exercise by inhibiting NICD-Notch Neovascularization is as important as mitochondria for rejuvenating muscle Graphical Abstract [DISPLAY OMISSION]

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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