본문 바로가기
HOME> 저널/프로시딩 > 저널/프로시딩 검색상세

저널/프로시딩 상세정보

권호별목차 / 소장처보기

H : 소장처정보

T : 목차정보

Seminars in immunology 11건

  1. [해외논문]   Nanoparticles: “magic bullets” for targeting the immune system   SCIE

    Granucci, Francesca
    Seminars in immunology v.34 ,pp. 1 - 2 , 2017 , 1044-5323 ,

    초록

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  2. [해외논문]   Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation   SCIE

    Silva, Ana Luí (Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal ) , sa (Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal ) , Peres, Carina (Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal ) , Conniot, Joã (Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal ) , o (Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal ) , Matos, Ana I. (Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal ) , Moura, Liane (Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Por) , Carreira, Bá , rbara , Sainz, Vanessa , Scomparin, Anna , Satchi-Fainaro, Ronit , Pré , at, Vé , ronique , Florindo, Helena F.
    Seminars in immunology v.34 ,pp. 3 - 24 , 2017 , 1044-5323 ,

    초록

    Abstract Nanotechnology-based strategies can dramatically impact the treatment, prevention and diagnosis of a wide range of diseases. Despite the unprecedented success achieved with the use of nanomaterials to address unmet biomedical needs and their particular suitability for the effective application of a personalized medicine, the clinical translation of those nanoparticulate systems has still been impaired by the limited understanding on their interaction with complex biological systems. As a result, unexpected effects due to unpredicted interactions at biomaterial and biological interfaces have been underlying the biosafety concerns raised by the use of nanomaterials. This review explores the current knowledge on how nanoparticle (NP) physicochemical and surface properties determine their interactions with innate immune cells, with particular attention on the activation of pattern-recognition receptors and inflammasome. A critical perspective will additionally address the impact of biological systems on the effect of NP on immune cell activity at the molecular level. We will discuss how the understanding of the NP-innate immune cell interactions can significantly add into the clinical translation by guiding the design of nanomedicines with particular effect on targeted cells, thus improving their clinical efficacy while minimizing undesired but predictable toxicological effects. Highlights Nanoparticle-innate immune cell interaction dictated by dynamic physicochemical properties. Adsorption of biological molecules onto nanoparticle surface leads to a new “biological identity”. Nanoparticles can fit distinct applications depending on the modulation of immune cell activity. A single nanoparticle can deliver multiple immune modulators. Graphical abstract [DISPLAY OMISSION]

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  3. [해외논문]   Effects of engineered nanoparticles on the innate immune system   SCIE

    Liu, Yuanchang (Corresponding author.) , Hardie, Joseph , Zhang, Xianzhi , Rotello, Vincent M.
    Seminars in immunology v.34 ,pp. 25 - 32 , 2017 , 1044-5323 ,

    초록

    Abstract Engineered nanoparticles (NPs) have broad applications in industry and nanomedicine. When NPs enter the body, interactions with the immune system are unavoidable. The innate immune system, a non-specific first line of defense against potential threats to the host, immediately interacts with introduced NPs and generates complicated immune responses. Depending on their physicochemical properties, NPs can interact with cells and proteins to stimulate or suppress the innate immune response, and similarly activate or avoid the complement system. NPs size, shape, hydrophobicity and surface modification are the main factors that influence the interactions between NPs and the innate immune system. In this review, we will focus on recent reports about the relationship between the physicochemical properties of NPs and their innate immune response, and their applications in immunotherapy. Highlights Physicochemical properties of NPs affect interactions with innate immune system. Engineered NPs are effective for immunomodulation. Immunotoxicity assays of NPs are challenging.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  4. [해외논문]   Nanoparticles and innate immunity: new perspectives on host defence   SCIE

    Boraschi, Diana (Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131 Napoli, Italy ) , Italiani, Paola (Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131 Napoli, Italy ) , Palomba, Roberto (Laboratory of Nanotechnology for Precision Medicine, Italian Institute of Technology Foundation, Via Morego 30, 16163 Genova, Italy ) , Decuzzi, Paolo (Laboratory of Nanotechnology for Precision Medicine, Italian Institute of Technology Foundation, Via Morego 30, 16163 Genova, Italy ) , Duschl, Albert (Department of Molecular Biology, Paris-Lodron Universität Salzburg, Hellbrunner Strasse 34, 5020 Salzburg, Austria ) , Fadeel, Bengt (Nanosafety and Nanomedicine Laboratory, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, 171 77 Stockholm, Sweden ) , Moghimi, S. Moein (School of Medicine, Pharmacy and Health, Durham University, Queen's Campus, Stockton-on-Tees TS17 6BH, UK)
    Seminars in immunology v.34 ,pp. 33 - 51 , 2017 , 1044-5323 ,

    초록

    Abstract The innate immune system provides the first line of defence against foreign microbes and particulate materials. Engineered nanoparticles can interact with the immune system in many different ways. Nanoparticles may thus elicit inflammation with engagement of neutrophils, macrophages and other effector cells; however, it is important to distinguish between acute and chronic inflammation in order to identify the potential hazards of nanoparticles for human health. Nanoparticles may also interact with and become internalised by dendritic cells, key antigen-presenting cells of the immune system, where a better understanding of these processes could pave the way for improved vaccination strategies. Nanoparticle characteristics such as size, shape and deformability also influence nanoparticle uptake by a plethora of immune cells and subsequent immune responses. Furthermore, the corona of adsorbed biomolecules on nanoparticle surfaces should not be neglected. Complement activation represents a special case of regulated and dynamic corona formation on nanoparticles with important implications in clearance and safety. Additionally, the inadvertent binding of bacterial lipopolysaccharide to nanoparticles is important to consider as this may skew the outcome and interpretation of immunotoxicological studies. Here, we discuss nanoparticle interactions with different cell types and soluble mediators belonging to the innate immune system. Highlights The innate immune system is the first to come in contact with NPs entering the body. Contamination of NPs with LPS may skew the interpretation of immunotoxicological data. NPs may elicit inflammation, but this is not per se a sign of toxicity. NPs may alter the polarisation of macrophages and the function of dendritic cells in antigen-presentation. NP size, shape, surface coating and deformability may influence their cellular uptake. Graphical abstract [DISPLAY OMISSION]

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  5. [해외논문]   Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System   SCIE

    Barbero, Francesco (Institut Català) , Russo, Lorenzo (de Nanociència i Nanotecnologia (ICN2), CSIC and The Barcelona Institute of Science and Technology (BIST), Campus UAB, 08193, Bellaterra, Barcelona, Spain ) , Vitali, Michele (Institut Català) , Piella, Jordi (de Nanociència i Nanotecnologia (ICN2), CSIC and The Barcelona Institute of Science and Technology (BIST), Campus UAB, 08193, Bellaterra, Barcelona, Spain ) , Salvo, Ignacio (Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain ) , Borrajo, Mireya L. (Institut Català) , Busquets-Fité (de Nanociència i Nanotecnologia (ICN2), CSIC and The Barcelona Institute of Science and Technology (BIST), Campus UAB, 08193, Bellaterra, Barcelona, Spain ) , , Marti (Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain ) , Grandori, Rita (Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain ) , Bastú (Applied Nanoparticles, S.L., C/Corsega 516, 2n, 1a, 08025 Barcelona, Spain ) , s, Neus G. (Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy ) , Casals, Eudald (Institut Català) , Puntes, Victor (de Nanociència i Nanotecnolog)
    Seminars in immunology v.34 ,pp. 52 - 60 , 2017 , 1044-5323 ,

    초록

    Abstract The interaction of inorganic nanoparticles and many biological fluids often withstands the formation of a Protein Corona enveloping the nanoparticle. This Protein Corona provides the biological identity to the nanoparticle that the immune system will detect. The formation of this Protein Corona depends not only on the composition of the nanoparticle, its size, shape, surface state and exposure time, but also on the type of media, nanoparticle to protein ratio and the presence of ions and other molecular species that interfere in the interaction between proteins and nanoparticles. This has important implications on immune safety, biocompatibility and the use of nanoparticles in medicine.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  6. [해외논문]   Drug nanocarriers to treat autoimmunity and chronic inflammatory diseases   SCIE

    Prosperi, Davide (Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy ) , Colombo, Miriam (Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy ) , Zanoni, Ivan (Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy ) , Granucci, Francesca (Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy)
    Seminars in immunology v.34 ,pp. 61 - 67 , 2017 , 1044-5323 ,

    초록

    Abstract Nanoparticles represent a new generation of drug delivery systems that can be engineered to harness optimal target selectivity for specific cells and tissues and high drug loading capacity, allowing for improved pharmacokinetics and enhanced bioavailability of therapeutics. The spontaneous propensity of both organic and colloidal nanoparticles to be captured by the cells of the reticuloendothelial system encouraged their utilization as passive targeting systems that can be preferentially directed to innate immune cells, such as macrophages, dendritic cells and neutrophils. The natural affinity for phagocytic cells suggests the possible implementation of nanoparticles as an immunotherapeutic platform for inflammatory diseases and autoimmune disorders. Here we discuss the recent advances in the application of nanotechnology to induce antigen-specific tolerance in autoimmunity and the use of nanoparticles for anti-inflammatory therapies, including treatment of inflammatory bowel diseases, psoriasis and rheumatoid arthritis.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  7. [해외논문]   Delivering the right message: Challenges and opportunities in lipid nanoparticles-mediated modified mRNA therapeutics—An innate immune system standpoint   SCIE

    Granot, Yasmin (Laboratory of Precision NanoMedicine, Dept. of Cell Research & Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv 69978, Israel ) , Peer, Dan (Laboratory of Precision NanoMedicine, Dept. of Cell Research & Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv 69978, Israel)
    Seminars in immunology v.34 ,pp. 68 - 77 , 2017 , 1044-5323 ,

    초록

    Abstract mRNA molecules hold tremendous potential as a tool for gene therapy of a wide range of diseases. However, the main hurdle in implementation of mRNA for therapeutics, the systemic delivery of mRNA molecules to target cells, remains a challenge. A feasible solution for this challenge relies in the rapidly evolving field of nucleic acid-loaded nanocarriers and specifically in the established family of lipid-based nanoparticles (LNPs). Herein, we will discuss the main factors, which determine the fate of modified mRNA (mmRNA)-loaded LNPs in-vivo, and will focus on their interactions with the innate immune system as a main consideration in the design of lipid-based mmRNA delivery platforms. Highlights Modified mRNA (mmRNA) has emerged as a promising approach for RNA therapy. The main challenge of systemic mmRNA delivery can be addressed by using lipid nanoparticles (LNPs). mRNA detection by intracellular pattern recognition receptors (PRR) can be reduced by mRNA chemical modifications. LNPs mostly interact with the Mononuclear Phagocytic system (MPS). Innate immune activation by mmRNA-LNPs can be altered by rational design of LNPs physicochemical properties.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  8. [해외논문]   Modulating the immune system through nanotechnology   SCIE

    Dacoba, Tamara G. (Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Campus Vida, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain ) , Olivera, Ana (Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Campus Vida, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain ) , Torres, Dolores (Department of Pharmacology, Pharmacy and Pharmaceutical Technology, School of Pharmacy, Campus Vida, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain ) , Crecente-Campo, José (Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Campus Vida, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain ) , (Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Campus Vida, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain) , Alonso, Marí , a José
    Seminars in immunology v.34 ,pp. 78 - 102 , 2017 , 1044-5323 ,

    초록

    Abstract Nowadays, nanotechnology-based modulation of the immune system is presented as a cutting-edge strategy, which may lead to significant improvements in the treatment of severe diseases. In particular, efforts have been focused on the development of nanotechnology-based vaccines, which could be used for immunization or generation of tolerance. In this review, we highlight how different immune responses can be elicited by tuning nanosystems properties. In addition, we discuss specific formulation approaches designed for the development of anti-infectious and anti-autoimmune vaccines, as well as those intended to prevent the formation of antibodies against biologicals. Highlights Nanocarriers can be designed to target specific immune cells. Nanovaccines may help fighting diseases that are elusive to traditional vaccines. Nanocarriers can bias the immune response from humoral to cellular. Autoimmune disease treatments can be improved with nanotechnology-based approaches. The use of nanocarriers may help to avoid ADAs formation against biotherapeutics. Graphical abstract [DISPLAY OMISSION]

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  9. [해외논문]   Targeting tumor associated macrophages: The new challenge for nanomedicine   SCIE

    Andó (Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Via A. Manzoni 113, 20089 Rozzano, Milan, Italy ) , n, Fernando Torres (Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Via A. Manzoni 113, 20089 Rozzano, Milan, Italy ) , Digifico, Elisabeth (Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Via A. Manzoni 113, 20089 Rozzano, Milan, Italy ) , Maeda, Akihiro (Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Via A. Manzoni 113, 20089 Rozzano, Milan, Italy ) , Erreni, Marco (Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Via A. Manzoni 113, 20089 Rozzano, Milan, Italy ) , Mantovani, Alberto (Center for Research in Molecular Medicine & Chronic Diseases (CIMUS), University of Santiago de Compostela, 15706 Campus Vida, Santiago de Compostela, Spain ) , Alonso, Marí (Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Via A. Manzoni 113, 20089 Rozzano, Milan, Italy) , a José , , Allavena, Paola
    Seminars in immunology v.34 ,pp. 103 - 113 , 2017 , 1044-5323 ,

    초록

    Abstract The engineering of new nanomedicines with ability to target and kill or re-educate Tumor Associated Macrophages (TAMs) stands up as a promising strategy to induce the effective switching of the tumor-promoting immune suppressive microenvironment, characteristic of tumors rich in macrophages, to one that kills tumor cells, is anti-angiogenic and promotes adaptive immune responses. Alternatively, the loading of monocytes/macrophages in blood circulation with nanomedicines, may be used to profit from the high infiltration ability of myeloid cells and to allow the drug release in the bulk of the tumor. In addition, the development of TAM-targeted imaging nanostructures, can be used to study the macrophage content in solid tumors and, hence, for a better diagnosis and prognosis of cancer disease. The major challenges for the effective targeting of TAM with nanomedicines and their application in the clinic have already been identified. These challenges are associated to the undesirable clearance of nanomedicines by, the mononuclear phagocyte system (macrophages) in competing organs (liver, lung or spleen), upon their intravenous injection; and also to the difficult penetration of nanomedicines across solid tumors due to the abnormal vasculature and the excessive extracellular matrix present in stromal tumors. In this review we describe the recent nanotechnology-base strategies that have been developed to target macrophages in tumors. Highlights Nanomedicines can be engineered to inhibit the recruitment, kill or re-educate TAM. Monocytes loaded with nanomedicines may be used as live cell-mediated drug delivery systems. Imaging TAM with nanoparticles can be applied for diagnosis and prognosis of cancer. The MPS is responsible for the undesirable clearance of nanomedicines in blood. Abnormal vessels and extracellular matrix prevent penetration of nanomedicines across the tumor. Graphical abstract [DISPLAY OMISSION]

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  10. [해외논문]   Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells   SCIE

    Shen, Haifa (Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA ) , Sun, Tong (Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA ) , Hoang, Hanh H. (Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA ) , Burchfield, Jana S. (Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA ) , Hamilton, Gillian F. (Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA ) , Mittendorf, Elizabeth A. (Department of Breast Surgical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA ) , Ferrari, Mauro (Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA)
    Seminars in immunology v.34 ,pp. 114 - 122 , 2017 , 1044-5323 ,

    초록

    Abstract Cancer immunotherapy has become arguably the most promising advancement in cancer research and therapy in recent years. The efficacy of cancer immunotherapy is critically dependent on specific physiological and physical processes – collectively referred to as transport barriers – including the activation of T cells by antigen presenting cells, T cells migration to and penetration into the tumor microenvironment, and movement of nutrients and other immune cells through the tumor microenvironment. Nanotechnology-based approaches have great potential to help overcome these transport barriers. In this review, we discuss the ways that nanotechnology is being leveraged to improve the efficacy and potency of various cancer immunotherapies.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지

논문관련 이미지