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Yonsei medical journal 13건

  1. [국내논문]   Oxygen, antioxidants and brain dysfunction.  

    Choi, B H
    Yonsei medical journal v.34 no.1 ,pp. 1 - 10 , 1993 , 0513-5796 ,

    초록

    Brain is a logical target of free radical damage, considering the large lipid content of myelin sheaths and the high rate of brain oxidative metabolism. Thus, the hypothesis that free radicals may be involved in the pathogenesis of certain CNS diseases has gained increasing popularity in recent years. In CNS ischemia-reperfusion injury, the role of free radicals appears to be well established, however, involvement of other factors, such as excitatory amino acids and prostaglandins, may also contribute to the production of neuronal necrosis following ischemia. Liberation of free iron appears to play a crucial role in the generation of reactive oxygen species in posttraumatic epilepsy. Although there is no direct evidence to indicate free radical involvement in the pathogenesis of Alzheimer's disease, brain trauma with release of iron, amyloid angiopathy and disturbances in blood-brain barrier function all appear to contribute to the development of ischemic episodes with free radical generation and neuronal degeneration. In Parkinson's disease, the substantia nigra appears to be under oxidative stress as evidenced by the findings of increased lipid peroxidation, reduced GSH levels, high concentration of iron and free radical generation via autocatalytic mechanisms within neuromelanin-containing catecholaminergic neurons. Regardless of the initial insult, a cascade of events involving both reactive oxygen radicals and mitochondrial metabolism is likely to contribute to cell injury.

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  2. [국내논문]   Hairy cell transformation of human peripheral blood lymphocytes by Coxiella burnetii.  

    Lee, W Y
    Yonsei medical journal v.34 no.1 ,pp. 11 - 21 , 1993 , 0513-5796 ,

    초록

    Hairy cell (HC) transformation of human peripheral blood lymphocytes (PBL) by Coxiella burnetii was studied to clarify the significance of persistency of C. burnetii in a hairy cell line (designated "TOL"). TOL cells which exhibited HC characteristics in hairy cell leukemia (HCL) were persistently infected with C. burnetii. Two strains of C. burnetii, our isolate from TOL cells and the original isolate in 1935, the Nine Mile strain from American Type Culture Collection (ATCC, U.S.A), were inoculated to PBL cultures. HC transformation not only by our isolates (87%) but also by Nine Mile strain (100%) was demonstrated in an average of 20 days. The original observation that Coxiella induced HC transformation in vitro was also confirmed in experiments with PBL exposed to C. burnetii in vivo. Spontaneous development of HC were observed in cultures of PBL only from coxiellemic cases (12/24) but not from C. burnetii negative cases (0/57). All HC cell lines (34) as determined by their morphology and cytochemical markers of HC in HCL remained infected with C. burnetii invariably.

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  3. [국내논문]   Current transition of the physician's professionalism and doctor-patient relationship.  

    Kim, H J , Park, C Y , Sohn, M
    Yonsei medical journal v.34 no.1 ,pp. 22 - 34 , 1993 , 0513-5796 ,

    초록

    In recent years, the physician's professionalism seemed to be facing or experiencing a phase of change. To investigate this phenomenon, social perception and attitude toward physicians were surveyed and analyzed. The subjects consisted of three types of sample group, namely, the general public, physicians, and medical students. Data were collected through interviews, mailing, and self-administered questionnaire surveys to each sample, respectively. The results of analysis showed us that social evaluation of physicians in Korean society exhibited ambivalent perceptions toward physicians. The physician's occupational status was generally evaluated by the three samples as being in a higher stratum in the social structure. But there were great gaps between their perceptions of the change in the physician's occupational status. While the general public perceived that the physician's status might improve in the future, physicians and medical students predicted an absolute declination of the status. Although the general public sympathized with the physician's characteristics as a professional group, an apparent tendency to assume the attitude of a fairly equal relationship toward physicians has increased. The transitional change in the physician's professionalism could be observed through the ubiquity in the perception of the patient's rights in doctor-patient relationships. Such phenomena are believed to have caused physicians to think that not only has their status declined in recent years but also that this declination of social status would continue in the future.

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  4. [국내논문]   Combined use of tamoxifen, cyclosporin A, and verapamil for modulating multidrug resistance in human hepatocellular carcinoma cell lines.  

    Kim, J H , Chung, J B , Park, I S , Kim, B S , Yoo, N C , Choi, J H , Roh, J K , Kim, H S , Kwon, O H , Lee, K S
    Yonsei medical journal v.34 no.1 ,pp. 35 - 44 , 1993 , 0513-5796 ,

    초록

    The intensive use of chemotherapeutic agents for the treatment of cancer has resulted in the cure or improved survival of many patients. But unfortunately, many cancers including human hepatocellular carcinoma (HCC) don't respond to chemotherapy. One of the major mechanisms for the drug resistance in the HCC is an elevated MDR1 RNA expression which makes cells become multidrug resistant. To overcome the multidrug resistance (MDR) phenotype, a high dose of verapamil is required both clinically and experimentally. Accordingly we have examined the MDR modulating effects with combinations of tamoxifen, cyclosporin A, and verapamil in vitro with the physiologically achievable concentrations of each agent, i.e., 2.0 microM/L for tamoxifen, 1.6 microM/L for cyclosporin A, and 2.5 microM/L for verapamil respectively in HCC lines. As expected, verapamil alone with the physiologically achievable concentration at which we tested didn't enhance the doxorubicin cytotoxicity in the HCC lines. Furthermore, any verapamil combination with cyclosporin A or tamoxifen was not effective in overcoming the doxorubicin resistance in the high MDR1 expressor (Hep-G2) line. However tamoxifen reduced the IC50 of doxorubicin by a factor of 1.9 in the low MDR1 expressor (SK-Hep1) and 1.1 in the high MDR1 expressor line (p

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  5. [국내논문]   Effect of anticancer drugs and desferrioxamine in combination with radiation on hepatoma cell lines.  

    Kim, W H , Chon, C Y , Moon, Y M , Kang, J K , Park, I S , Choi, H J
    Yonsei medical journal v.34 no.1 ,pp. 45 - 56 , 1993 , 0513-5796 ,

    초록

    Several anticancer chemotherapeutic agents (5-fluorouracil, adriamycin and cisplatinum) and desferrioxamine, an iron chelator, were tested with regard to cytotoxicity and to the combined effect on radiation induced cell killing using two human hepatoma cell lines (HepG2 and PLC/PRF/5). Survival fractions were measured by quantitative colorimetric assay (MTT assay) and dose-response curves were plotted. MTT assay could be successfully used in the assessment of radiosensitivity in addition to chemosensitivity, because a good linear relationship between optical densities and cell numbers was observed and cells approached exponential growth for the first 7 days of culture when 5 x 10(3) or less cells were inoculated per well in our study. Steepness of the final slope (D0), width of the shoulder (D0) and the extrapolation number (n) of radiation survival curves were 1061.72 rad, 226.43 rad and 1.25 respectively in HepG2 and 1091.38 rad, 268.42 rad and 1.29 respectively in PLC/PRF/5. After combining anticancer chemotherapeutic agents and desferrioxamine with radiation, the widths of the shoulders were decreased whereas sensitizer enhancement ratios were increased as the concentration of drugs increased in both cell lines. These results suggest that neither anticancer chemotherapeutic agents nor desferrioxamine enhance cell killing induced by radiation alone, but suggested the possibility that they inhibit the repair of radiation damage.

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  6. [국내논문]   Peak bone mass and affecting factors in Korean women.  

    Lim, S K , Lee, N H , Lee, J H , Choi, M S , Chung, Y S , Ahn, K J , Lee, H C , Huh, K B
    Yonsei medical journal v.34 no.1 ,pp. 57 - 62 , 1993 , 0513-5796 ,

    초록

    Maximizing peak bone mass is advocated as a way to prevent osteoporosis. To evaluate the peak bone mass and the affecting factors in Korean women, we analyzed bone stiffness in 116 middle school students, 118 high school students and 115 female college students by using the Achilles densitometer (Lunar Corporation). Peak bone stiffness of Korean women was relatively lower than that of white women (94% of white women) and a rapid rise of bone stiffness was observed in those subjects 3-4 years after menarche. In adolescent females without menstruation, the bone stiffness was lower than that of adolescent girls with menstruation. The factors affecting the peak bone mass was similar to the risk factors of post menopausal osteoporosis: menstruation status, calcium intake and physical activity. The amount of calcium intake in Korean girls at the critical age (3-4 years after menarche) was lower than the RDA (requirement of daily allowance) at this age. To improve any program aimed at maximizing peak bone mass, further intensive study will be required to evaluate some other common factors affecting peak bone mass in Korean.

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  7. [국내논문]   Enoximone therapy as pharmacological bridging to cardiac transplantation.  

    Park, J W , Wirtz, J H , May, E , Mertens, S , Braun, P , Heinzler, R , Hetzer, R , Kang, C S , Heinrich, K W
    Yonsei medical journal v.34 no.1 ,pp. 63 - 70 , 1993 , 0513-5796 ,

    초록

    Keeping pre-transplant patients alive while waiting for a suitable donor is still a major challenge. New pharmacological agents which can provide improved hemodynamics are urgently needed in patients with severe heart failure who are on the waiting list for cardiac transplantation. Intravenous enoximone therapy (an initial 0.5 mg/kg bolus, then 1.25-5.0 mcg/kg/min infusion) was administered to 35 transplant candidates with progressive heart failure despite optimal drug regimen including digoxin, diuretics, and ACE-inhibitors. In 18 out of 35 patients complete hemodynamic, echocardiographic, neurohumoral, and Holter-ECG studies were performed before and 24 hours after intravenous enoximone infusion. Patients were then continued on chronic oral therapy of 100 mg twice a day. Enoximone infusion increased the cardiac index (CI) (1.78 +/- 0.45 l/min/m2 vs 3.04 +/- 0.83 l/min/m2; p

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  8. [국내논문]   Pudendal somatosensory evoked potential and bulbocavernosus reflex testing in erectile dysfunction.  

    Moon, J H , Kang, S W , Chun, S I
    Yonsei medical journal v.34 no.1 ,pp. 71 - 77 , 1993 , 0513-5796 ,

    초록

    Pudenal somatosensory evoked potential (PSEP) and bulbocavernosus reflex (BCR) testing have been reported to be useful in the evaluation of erectile dysfunction and neurogenic bladder. 461 patients with sexual dysfunction were studied to determine the usefulness of the above tests. Abnormality of PSEP was found significantly in upper motor neuron (UMN) type spinal cord patients and average prolonged P1 latency was 47.4 +/- 9.8 msec. Lower motor neuron (LMN) type spinal cord patients revealed great abnormality in BCR latency with an average value of 44.9 +/- 14.5 msec on the right and 44.2 +/- 15.6 msec on the left. Additionally significant differences were obtained in patients with diabetes mellitus, pelvic trauma and spinal cord lesion of the UMN type in the study of PSEP. There was also a significant difference in the patients with diabetes mellitus, pelvic trauma and spinal cord lesion of the LMN type in the BCR study. The findings of our study suggest that PSEP together with BCR study is useful in assessing the integrity of the sacral reflex arc and the central afferent pathway, in differentiating the lesion site and in providing basic data for the management plan in sexual rehabilitation. Furthermore, because erection is under the influence of both the somatic and autonomic nervous system, BCR study and PSEP combined with currently studied electrical activity of the corpus cavernosum would provide a more accurate evaluation of the neurogenic erectile dysfunction patients.

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  9. [국내논문]   Trend of isolation and serotypes of group B streptococci in Korea.  

    Chong, Y , Lee, K , Kwon, O H , Nahm, C H , Murai, T , Inazumi, Y
    Yonsei medical journal v.34 no.1 ,pp. 78 - 83 , 1993 , 0513-5796 ,

    초록

    Group B streptococci (GBS) neonatal infection, a prevalent disease in western countries, is considered rare in Korea. GBS neonatal infection is known to be often due to serotype III organisms, but the serotypes in Korea have not been reported. In this study, GBS were frequently isolated from specimens of genitalia, urine and various pus. Among the 186 isolates 14 (7.5%) were from neonates, two with concomitant bacteremia and meningitis and one with pneumonia. Frequently isolated GBS serotypes were Ib (9.2%), Ib/c (26.6%) and III/R (23.9%). Change of frequently isolated serotypes during the study was noted, but JM9 which became increasingly isolated in Japan was not found. It is concluded that less prevalence of severe neonatal GBS infection in Korea is not due to the absence of serotype III, but possibly due to low genital carriage rate of GBS by pregnant women.

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  10. [국내논문]   Relationship between electromyography and computed tomography in the evaluation of low back pain.  

    Park, E S , Park, C I , Kim, A Y , Park, M K
    Yonsei medical journal v.34 no.1 ,pp. 84 - 89 , 1993 , 0513-5796 ,

    초록

    In a group of 109 patients with low back pain, the electromyographic(EMG) findings were compared with computed tomographic (CT) findings. There were 64 (58.7%) patients who had abnormal EMG results combined with abnormal CT findings. 11 (10.1%) cases had abnormal EMG and normal CT findings, another 11 (10.1%) patients had abnormal CT and normal EMG findings. 33 patients underwent operation; nerve root compressions were confirmed in all those with abnormal EMG findings, and 32 of those with abnormal CT findings. Among 33 surgical cases, 24 (72.7%) patients had abnormal EMG findings in both paralumbar and lower extremity muscles. In 9 (27.3%) patients there was evidence of abnormal EMG findings in the paralumbar muscles only. Among 46 who had abnormal EMG findings in paralumbar and lower limb muscles, 44 (95.6%) patients had combined CT abnormalities, and in the remaining 2 patients, nerve root 'compression was confirmed by surgery in 1 case and by myelogram in the other. In 29 cases with abnormal EMG findings in the paralumbar muscles only, 20 (69.0%) patients had combined CT abnormalities. In comparing normal versus abnormal EMG findings of the paralumbar muscles only, a significantly higher percentage of abnormal CT results were found among the abnormal EMG findings. These results indicate that abnormal EMG findings in both the paralumbar and lower limb muscles, strongly suggests the presence of nerve root compression. In cases where there are abnormal EMG findings in the paralumbar muscles only, it is recommended that CT scan must be done for the correct diagnosis of low back pain.

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