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T : 목차정보

Yonsei medical journal 21건

  1. [국내논문]   Rapid Prenatal Diagnosis of Trisomy 21 by Real-time Quantitative Polymerase Chain Reaction with Amplification of Small Tandem Repeats and S100B in Chromosome 21  

    Yang, Young Ho (Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. ) , Nam, Mi Suk (Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. ) , Yang, Eun Suk (Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.)
    Yonsei medical journal v.46 no.2 ,pp. 193 - 197 , 2005 , 0513-5796 ,

    초록

    Trisomy 21 (Down syndrome) is the most common congenital anomaly, and it occurs in one out of 700-1000 births. Current techniques such as amniocentesis and chorionic villi sampling (CVS) require lengthy laboratory culture procedures and high costs. This study was undertaken to establish a rapid prenatal diagnosis of trisomy 21 using real-time quantitative polymerase chain reaction (PCR) of fetal DNA from amniotic fluid. Real-time quantitative PCR was performed with DNA templates obtained from 14 normal blood samples, 10 normal amniotic fluid samples, 14 Down syndrome blood samples, and 7 Down syndrome amniotic fluid samples. Primers for D21S167 and S100B of chromosome 21 were used. Primers that direct the amplification of the 165-bp fragment of the insulin-like growth factor (IGF)-1 gene on chromosome 12 using a PCR primer were included to generate an internal standard for quantitation. The relative levels of D21S167 and S100B were 2.6 and 2.4 times higher in the blood of Down syndrome patients than those in the control group. The differences between these two groups were statistically significant ( p -values were 0.0012 and 0.0016, respectively). The relative levels of D21S167 and S100B were 2.1 and 2.7 times higher in the amniotic fluid of Down syndrome fetuses than those in the control group. The difference between these two groups was statistically significant ( p -values were 0.0379 and 0.0379, respectively). Prenatal diagnosis of trisomy 21 by real-time quantitative PCR using STR (small tandem repeats) amplification of D21S167 and S100B is a useful, accurate and rapid diagnostic method. Furthermore, it may also be useful for prenatal diagnosis with fetal DNA from maternal blood, and for preimplantation genetic diagnosis and prenatal counseling.

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  2. [국내논문]   The Prevalence of the Metabolic Syndrome in Korean Adults: Comparison of WHO and NCEP Criteria  

    Choi, Sung Hee (Division of Endocrinology, Department of Internal Medicine, Seoul National University College of Medicine, Seongnam, Korea. ) , Ahn, Chul Woo (Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ) , Cha, Bong Soo (Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ) , Chung, Yoon-Sok (Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea. ) , Lee, Kwan Woo (Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea. ) , Lee, Hyun Chul (Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ) , Huh, Kap Bum (Huh's Diabetes Center and 21 century Diabetes and Vascular Research Institute, Seoul, Korea. ) , Kim, Dae Jung (Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea.)
    Yonsei medical journal v.46 no.2 ,pp. 198 - 205 , 2005 , 0513-5796 ,

    초록

    The aims of this study were to compare the prevalence of the metabolic syndrome according to the WHO and NCEP ATP III criteria in Korean adults, and to compare the prevalence of the metabolic syndrome with the results in previous Korean studies. The study comprised 1,230 subjects (627 men, 603 women) aged 30-79 years (mean 52.4±10.3 years) who underwent medical check-up from April to June, 2001 in the Korea Association of Health (KAH). The prevalence of the metabolic syndrome according to the modified WHO criteria was 21.8% of men and 19.4% of women. However, the prevalence was increased 1.6 times (34.2%) in men and 2.0 times (38.7%) in women using the modified NCEP criteria. The prevalence of the metabolic syndrome has varied widely according to differences in the criteria. Thus, further studies are necessary to define the appropriate criteria of the metabolic syndrome for Korean adults.

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  3. [국내논문]   The Effects of the Acupuncture Treatment for Smoking Cessation in High School Student Smokers  

    Kang, Hee-Cheol (Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea. ) , Shin, Kyung-Kyun (Department of Family Medicine, PochonCha University College of Medicine, Kyunggi-do, Korea. ) , Kim, Kyoung-Kon (Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea. ) , Youn, Bang-Bu (Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.)
    Yonsei medical journal v.46 no.2 ,pp. 206 - 212 , 2005 , 0513-5796 ,

    초록

    The use of alternative medicine for smoking cessation have been increasing steadily in recent years. A series of clinical group studies was performed to clarify the effect, outcome and success rate of an acupuncture treatment for smoking cessation. This study was conducted for four weeks using 238 smoking students at 2 high schools. The subjects were separated into two groups: 159 students were treated with acupuncture on the anti-smoking acupoints of the ear, which is known to be effective for cessation of smoking (case group), and 79 students were treated at other sites of the ear (control group). The acupuncture treatment was alternately administered at each side of the ears on a weekly basis for 4 weeks. The smoking cessation success was only 1 case (0.6%) in the case group and none in the control group after 4 weeks. The change in the taste of tobacco and the intensity of the desire to smoke were not significantly different between the case and control groups, but the case group showed a tendency of reduction in the taste of tobacco and the intensity of the desire to smoke. In addition, the reduction in cigarette consumption was not significant, but the tendency of reduction in the study group was significant. It is believed that the site of auricular acupuncture for smoking cessation is not important. However, there was a significant tendency in terms of the reduction in cigarette consumption, the taste of tobacco and the intensity of the desire to smoke in the case group, indicating that auricular acupuncture in smoking cessation has some effect.

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  4. [국내논문]   Clinical Usefulness of Cervicogram as a Primary Screening Test for Cervical Neoplasia  

    Kim, Young Tae (Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. ) , Kim, Jae Wook (Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. ) , Kim, Sung Hoon (Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. ) , Kim, Yu Ri (Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. ) , Kim, Jae Hoon (Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. ) , Yoon, Bo Sung (Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. ) , Park, Yong Won (Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.)
    Yonsei medical journal v.46 no.2 ,pp. 213 - 220 , 2005 , 0513-5796 ,

    초록

    The purpose of this study is to evaluate the clinical usefulness of the cervicogram as a primary screening test for cervical neoplasia. A total of 294 women who had undergone a cervicogram and a Pap test between January and July 2003, were selected. The diagnostic accuracy of the Pap test, cervicogram, and the Pap test combined with a cervicogram were compared with the histopathologic diagnosis. Among 294 women, the Pap test was negative in 130 cases and positive in 164 cases. Among patients with positive Pap test, cervicogram were negative in 101 cases (61.6%) and positive in 63 cases (38.4%). The diagnostic accuracy between cervicogram with positive Pap test and histology was as follows; sensitivity 44.9%, specificity 78.3%, positive predictive value 84.1%, negative predictive value 32.7%, false positive rate 15.9%, and false negative rate 67.3%. Although the adjunctive use of cervicogram with the Pap test in the initial screening of cervical neoplasia showed a higher specificity and higher positive predictive value compared to the Pap test alone, consideration in terms of lower sensitivity, lower positive predictive value, higher false positive rate and cost-effectiveness should be given in lieu of clinically applying cervicogram with the pap test as an initial screening test.

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  5. [국내논문]   Prognostic Value of Tumor Volume in Nasopharyngeal Carcinoma  

    Kim, Jeong-Hyun (Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School & Hospital, Gwangju, Korea. ) , Lee, Joon-Kyoo (Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School & Hospital, Gwangju, Korea.)
    Yonsei medical journal v.46 no.2 ,pp. 221 - 227 , 2005 , 0513-5796 ,

    초록

    Tumor bulk has been recognized as an important prognostic factor in the treatment of malignancy. The purpose of the present study is to investigate the prognostic value of tumor volume in nasopharyngeal carcinoma. Sixty patients with nasopharyngeal carcinoma were included in this study. Tumor contour was outlined on each of the computed tomography (CT) images using an image analyzer. The primary tumor volume (PTV) and nodal tumor volume (NTV) were calculated by a summation-of-areas technique, and the maximal perimeter of primary tumor (MPP) was measured. The loco-regional control rates and disease-specific survival rates were analyzed according to several variables. The patients had a 5-year local control rate of 75.5%, 5-year nodal control rate of 74.6%, and 5-year disease-specific survival rate of 60.2%. Large PTV (> 30 cm 3 ) was associated with a significantly lower local control ( p = 0.005). Large NTV (> 5 cm 3 ) was associated with a significantly lower nodal control ( p = 0.019) and lower disease-specific survival ( p = 0.046). Large MPP (> 18 cm) was associated with a significantly lower local control ( p = 0.017). In multivariate analysis, the PTV and NTV were found to be independent factors in predicting the local ( p = 0.015) and nodal ( p = 0.039) control, respectively. The NTV ( p = 0.012) and cranial nerve involvement ( p = 0.009) were factors that predicted disease-specific survival. Our results suggest that the estimation of tumor volume may identify a subgroup of patients with a greater risk of loco-regional failure and can be used to refine the current staging system.

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  6. [국내논문]   Chondrosarcoma of the Head and Neck  

    Lee, Sei Young (Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, Korea. ) , Lim, Young Chang (Department of Otolaryngology-Head and Neck Surgery, Konkuk University College of Medicine, Seoul, Korea. ) , Song, Mee Hyun (Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea. ) , Seok, Jae Yeon (Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. ) , Lee, Won Sang (Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea. ) , Choi, Eun Chang (Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.)
    Yonsei medical journal v.46 no.2 ,pp. 228 - 232 , 2005 , 0513-5796 ,

    초록

    Chondrosarcoma of the head and neck region is a rare disease, representing approximately 0.1% of all head and neck neoplasms. The 5-year survival rate of chondrosarcoma is 70-80%, showing relatively good prognosis; however, it is known to progress slowly and eventually cause multiple metastases. In this study, we reviewed chondrosarcoma cases experienced at Yonsei University Medical College during the last 15 years to investigate its clinical characteristics and treatment outcome. The medical records of 8 patients who were diagnosed with chondrosarcoma of the head and neck region and underwent surgical treatment between December 1990 and December 2002 were retrospectively reviewed. The primary sites were sinus, mastoid, jugular foramen and thyroid cartilage. In all patients, the initial treatment modality was surgery, and postoperative radiation therapy was performed in 4 cases. The pathological findings showed chondrosarcoma in 7 cases and mesenchymal chondrosarcoma in 1 case. The treatment outcome resulted in 3 cases of recurrence, of which 2 cases were treated successfully and the other case expired of disease, indicating a survival rate of 87.5%. In the case that resulted in death, complete excision could not be achieved. Therefore, we concluded that wide excision is a beneficial initial treatment of this rare disease.

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  7. [국내논문]   Assisted Cough and Pulmonary Compliance in Patients with Duchenne Muscular Dystrophy  

    Kang, Seong Woong (Department of Physical Medicine & Rehabilitation, Rehabilitation Institute of Muscular Disease, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. ) , Kang, Yeoun Seung (Department of Physical Medicine & Rehabilitation, Rehabilitation Institute of Muscular Disease, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. ) , Moon, Jae Ho (Department of Physical Medicine & Rehabilitation, Rehabilitation Institute of Muscular Disease, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. ) , Yoo, Tae Won (Department of Physical Medicine & Rehabilitation, Rehabilitation Institute of Muscular Disease, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.)
    Yonsei medical journal v.46 no.2 ,pp. 233 - 238 , 2005 , 0513-5796 ,

    초록

    The aim of this study was to investigate the factors affecting cough ability, and to compare the assisted cough methods in patients with Duchenne muscular dystrophy (DMD). A total seventy-one male patients with DMD were included in the study. The vital capacity (VC) and maximum insufflation capacity (MIC) were measured. The unassisted peak cough flow (UPCF) and three different techniques of assisted peak cough flow were evaluated. UPCF measurements were possible for all 71 subjects. But when performing the three different assisted cough techniques, peak cough flows (PCFs) could be obtained from only 51 subjects. The mean value of MICs (1801 ± 780 cc) was higher than that of VCs (1502 ± 765 cc) ( p p p

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  8. [국내논문]   Effects of air pollutants on childhood asthma.  

    Kim, Jeong-Hee , Kim, Ja-Kyoung , Son, Byong-Kwan , Oh, Ji-Eun , Lim, Dae-Hyun , Lee, Kwan-Hee , Hong, Youn-Chol , Cho, Sung-Il
    Yonsei medical journal v.46 no.2 ,pp. 239 - 244 , 2005 , 0513-5796 ,

    초록

    Epidemiologic studies have suggested the association between environmental exposure to volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) and the increased risk of incurring asthma. Yet there is little data regarding the relationship between personal exposure to air pollution and the incidence of asthma in children. This study was designed to evaluate the effect of exposure to air pollution on children with asthma by using exposure biomarkers. We assessed the exposure level to VOCs by measuring urinary concentrations of hippuric acid and muconic acid, and PAHs by 1-OH pyrene and 2-naphthol in 30 children with asthma and 30 children without asthma (control). The mean level of hippuric acid was 0.158 +/- 0.169 micromol/mol creatinine in the asthma group and 0.148 +/- 0.249 micromol/mol creatinine in the control group, with no statistical significance noted (p=0.30). The mean concentration of muconic acid was higher in the asthma group than in the control group (7.630 +/- 8.915 micromol/mol creatinine vs. 3.390 +/- 4.526 micromol/mol creatinine p=0.01). The mean level of urinary 1-OHP was higher in the asthma group (0.430 +/- 0.343 micromol/mol creatinine) than the control group (0.239 +/- 0.175 micromol/mol creatinine), which was statistically significant (p=0.03). There was no difference in the mean concentration of 2-NAP between the two groups (9.864 +/- 10.037 micromol/mol in the asthma group vs. 9.157 +/- 9.640 micromol/mol in the control group, p=0.96). In conclusion, this study suggests that VOCs and PAHs have some role in asthma.

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  9. [국내논문]   The Effects of Ketorolac Injected via Patient Controlled Analgesia Postoperatively on Spinal Fusion  

    Park, Si-Young (Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, Korea. ) , Moon, Seong-Hwan (Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, Korea. ) , Park, Moon-Soo (Department of Orthopaedic Surgery, Ulsan University College of Medicine, Seoul, Korea. ) , Oh, Kyung-Soo (Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, Korea. ) , Lee, Hwan-Mo (Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, Korea.)
    Yonsei medical journal v.46 no.2 ,pp. 245 - 251 , 2005 , 0513-5796 ,

    초록

    Lumbar spinal fusions have been performed for spinal stability, pain relief and improved function in spinal stenosis, scoliosis, spinal fractures, infectious conditions and other lumbar spinal problems. The success of lumbar spinal fusion depends on multifactors, such as types of bone graft materials, levels and numbers of fusion, spinal instrumentation, electrical stimulation, smoking and some drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs). From January 2000 to December 2001, 88 consecutive patients, who were diagnosed with spinal stenosis or spondylolisthesis, were retrospectively enrolled in this study. One surgeon performed all 88 posterolateral spinal fusions with instrumentation and autoiliac bone graft. The patients were divided into two groups. The first group (n=30) was infused with ketorolac and fentanyl intravenously via patient controlled analgesia (PCA) postoperatively and the second group (n=58) was infused only with fentanyl. The spinal fusion rates and clinical outcomes of the two groups were compared. The incidence of incomplete union or nonunion was much higher in the ketorolac group, and the relative risk was approximately 6 times higher than control group (odds ratio: 5.64). The clinical outcomes, which were checked at least 1 year after surgery, showed strong correlations with the spinal fusion status. The control group (93.1%) showed significantly better clinical results than the ketorolac group (77.6%). Smoking had no effect on the spinal fusion outcome in this study. Even though the use of ketorolac after spinal fusion can reduce the need for morphine, thereby decreasing morphine related complications, ketorolac used via PCA at the immediate postoperative state inhibits spinal fusion resulting in a poorer clinical outcome. Therefore, NSAIDs such as ketorolac, should be avoided after posterolateral spinal fusion.

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  10. [국내논문]   Behavioral Characteristics of a Mouse Model of Cancer Pain  

    Lee, Bae Hwan (Medical Research Center, Department of Physiology, Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea. ) , Seong, Jinsil (Department of Radiation Oncology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. ) , Kim, Un Jeng (Medical Research Center, Department of Physiology, Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea. ) , Won, Ran (Medical Research Center, Department of Physiology, Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea. ) , Kim, Jiyoung (Department of Radiation Oncology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.)
    Yonsei medical journal v.46 no.2 ,pp. 252 - 259 , 2005 , 0513-5796 ,

    초록

    Pain is a major symptom in cancer patients, and most cancer patients with advanced or terminal cancers suffer from chronic pain related to treatment failure and/or tumor progression. In the present study, we examined the development of cancer pain in mice. Murine hepatocarcinoma cells, HCa-1, were inoculated unilaterally into the thigh or the dorsum of the foot of male C3H/HeJ mice. Four weeks after inoculation, behavioral signs were observed for mechanical allodynia, cold allodynia, and hyperalgesia using a von Frey filament, acetone, and radiant heat, respectively. Bone invasion by the tumor commenced from 7 days after inoculation of tumor cells and was evident from 14 days after inoculation. Cold allodynia but neither mechanical allodynia nor hyperalgesia was observed in mice that received an inoculation into the thigh. On the contrary, mechanical allodynia and cold allodynia, but not hyperalgesia, were developed in mice with an inoculation into the foot. Sometimes, mirror-image pain was developed in these animals. These results suggest that carcinoma cells injected into the foot of mice may develop severe chronic pain related to cancer. This animal model of pain would be useful to elucidate the mechanisms of cancer pain in humans.

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