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Journal of medical virology 18건

  1. [해외논문]   Cover Image, Volume 90, Number 9, September 2018  

    Ding, Ling (MOE & MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China) , Mo, Xiaohui (MOE & MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China) , Zhang, Liming (Medical Laboratory, Nanchang Hospital of Integrative Traditional Chinese and Western Medicine, Nanchang, China) , Zhou, Feng (MOE & MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China) , Zhu, Caixia (MOE & MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China) , Wang, Yuyan , Cai, Cankun , Liu, Yeqiang , Wei, Fang , Cai, Qiliang
    Journal of medical virology v.90 no.9 ,pp. i - i , 2018 , 0146-6615 ,

    초록

    Cover Caption : The cover image, by Ling Ding et al., is based on the Research Article High prevalence and correlates of human herpesvirus‐6A in nevocytic nevus and seborrheic diseases: Implication from a pilot study of skin patient tissues in Shanghai , DOI: 10.1002/jmv.25262 .

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  2. [해외논문]   Age‐specific seroprevalence of dengue infection in Hong Kong  

    Lee, Polly (Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong) , Yeung, Apple C.M. (Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong) , Chen, Zigui (Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong) , Chan, Martin C.W. (Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong) , Sze, Kin Ho (Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong) , Chan, Paul K.S. (Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong)
    Journal of medical virology v.90 no.9 ,pp. 1427 - 1430 , 2018 , 0146-6615 ,

    초록

    A newly developed dengue virus vaccine (chimeric yellow fever virus‐tetravalent dengue vaccine [CYD‐TDV]) has recently been licensed for clinical use. The World Health Organization recommends vaccination for populations with seroprevalence of at least 70% to maximize public health impact. This study aimed to delineate the seroprevalence of dengue infection in Hong Kong. A total of 105 972 serum samples submitted for clinical testing during the period 2013‐2015 were age‐stratified and sex‐stratified. For each year of collection, 25 samples were randomly selected from each age‐sex group. Altogether, 2100 samples were tested for the dengue immunoglobulin G (IgG) antibody using a non‐type–specific ELISA kit. The overall dengue IgG‐positive rate was 4.6% and showed no significant change over the 3 years. The positive rate was not associated with sex, but a steep rise in seroprevalence for persons above 65 years (32.7%) was observed. The low dengue seroprevalence in Hong Kong does not support implementation of a national immunization program. Majority of the population in Hong Kong are susceptible to dengue infection, and a substantial proportion of persons older than 65 years could acquire secondary infection and are prone to develop severe dengue.

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  3. [해외논문]   Treatment with broadly neutralizing influenza antibodies reduces severity of secondary pneumococcal pneumonia in mice  

    van Someren Gré (Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands) , ve, Frank (Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Academic Medical Center, Amsterdam, The Netherlands) , van der Sluijs, Koenraad F. (Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Academic Medical Center, Amsterdam, The Netherlands) , Tuip, Anita M. (Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands) , Schultz, Marcus J. (Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands) , de Jong, Menno D. (Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands) , Juffermans, Nicole P.
    Journal of medical virology v.90 no.9 ,pp. 1431 - 1437 , 2018 , 0146-6615 ,

    초록

    Secondary bacterial pneumonia is a frequent complication of influenza, associated with high morbidity and mortality. We hypothesized that treatment with neutralizing influenza A antibody AT10_002 protects against severe secondary pneumococcal infection in a mouse model of influenza A infection. Influenza A (H3N2) virus–infected male C57Bl6 mice were treated intravenously with either AT10_002 or a control 2 days postinfection. Seven days later, both groups were infected with Streptococcus pneumoniae and killed 18 hours later. Mice receiving AT10_002 showed less loss of bodyweight compared with controls (+1% vs −12%, P P 1 vs 2.5 × 10 5 colony‐forming units per mg; P

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  4. [해외논문]   Kinetics of torque teno virus DNA load in saliva and plasma following allogeneic hematopoietic stem cell transplantation  

    Albert, Eliseo (Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain) , Torres, Ignacio (Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain) , Talaya, Alberto (Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain) , Gimé (Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain) , nez, Estela (Hematology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain) , Piñ (Hematology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain) , ana, José (Department of Transfusion Medicine, North‐Western Tuscany Blood Bank, Pisa University Hospital, Pisa, I) , Luis , Herná , ndez‐ , Boluda, Juan Carlos , Focosi, Daniele , Macera, Lisa , Maggi, Fabrizio , Solano, Carlos , Navarro, David
    Journal of medical virology v.90 no.9 ,pp. 1438 - 1443 , 2018 , 0146-6615 ,

    초록

    Plasma torque teno virus (TTV) DNA load directly correlates with the degree of T‐cell immune reconstitution early after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Here, the kinetics of oral TTV DNA shedding was examined to assess whether quantitation of TTV DNA load in saliva may either replace or complement that in plasma for predicting lymphocyte (ALC) reconstitution after engraftment. This prospective observational study enrolled 38 nonconsecutive allo‐HSCT recipients. Saliva and plasma specimens were collected at baseline (pretransplant) and at around days +30, +50, and +90 after allo‐HSCT. TTV DNA was quantitated in both specimen types by real‐time PCR. ALCs were measured by cytometry. A total of 104 paired saliva and plasma specimens were available for TTV PCR analyses. TTV DNA was detected more frequently in saliva than in plasma specimens at all time points (overall, 94.2% vs 86.5%). Increasing levels of TTV DNA were seen in both specimen types from day +30 to day +90 after transplantation. Overall, TTV DNA loads were significantly higher in saliva than in plasma specimens ( P = .0002) and correlated significantly ( P ≤ .0001). A direct correlation between TTV DNA loads in saliva and plasma and ALCs was observed after engraftment ( P = .034 and P = .002, respectively). Future studies should be aimed at determining whether monitoring of oral TTV DNA shedding may be of any utility for inference of immune reconstitution after allo‐HSCT.

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  5. [해외논문]   Molecular detection and phylogenetic analysis of human parechovirus in individuals with acute diarrhea and healthy controls in Guangzhou, China  

    Chen, Xuejiao (Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China) , Shi, Tingli (Department of Hospital Infection Management, The Third People's Hospital of Hainan Province, Sanya, China) , Huang, Jianhua (Public Health Emergency Preparedness and Response Division, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China) , Xiao, Gang (Department of Medical Laboratory, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China) , Huang, Jing (Department of Medical Laboratory, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China) , Xiong, Yiquan (Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, C) , Li, Xiufen , Chen, Huifang , Zheng, Xueyan , Yu, Shouyi , Chen, Qing
    Journal of medical virology v.90 no.9 ,pp. 1444 - 1452 , 2018 , 0146-6615 ,

    초록

    Human parechoviruses (HPeVs) are prevalent in young children; however, their effects are incompletely understood. We investigated the prevalence, genotype distribution, and phylogeny of HPeVs in individuals with diarrhea (n = 430) and healthy controls (n = 93) by the analysis of stool specimens collected from July 2013 to December 2014; 51 (11.86%) and 6 (6.45%) specimens were HPeV positive, respectively. HPeV1A occurred in 28 (6.51%) and 6 (6.45%) individuals with diarrhea and controls, respectively, whereas HPeV1B (3.95%), HPeV3 (0.23%), HPeV4 (0.70%), and HPeV14 (a rare genotype, 0.47%) were only detected in individuals with diarrhea. There was no significant difference in the rate of HPeV detection between the 2 groups; however, the mean age of HPeV infection was significantly lower in males. We conclude that HPeVs may be opportunistic pathogens associated with acute diarrhea. Immunocompromised individuals, such as children aged under 2 years and the elderly, could be vulnerable to HPeV infections.

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  6. [해외논문]   Rotavirus and norovirus in children with severe diarrhea in Burkina Faso before rotavirus vaccine introduction  

    Bonkoungou, Isidore Juste O. (UFR/SVT, Department of Biochemistry and Microbiology, University Ouaga 1, Pr Joseph KI‐ZERBO, Ouagadougou, Burkina Faso) , Oué (UFR/SVT, Department of Biochemistry and Microbiology, University Ouaga 1, Pr Joseph KI‐ZERBO, Ouagadougou, Burkina Faso) , draogo, Nafissatou (UFR/SVT, Department of Biochemistry and Microbiology, University Ouaga 1, Pr Joseph KI‐ZERBO, Ouagadougou, Burkina Faso) , Tamini, Laure (Department of Medical Biology, National Public Health Laboratory, Ouagadougou, Burkina Faso) , Teguera, Rabieta Kouboura (Department of Medical Biology, National Public Health Laboratory, Ouagadougou, Burkina Faso) , Yamé (Department of Medical Biology, National Public Health Laboratory, Ouagadougou, Burkina Faso) , ogo, Pouiré (National Immunization Program, Ministry of Health, Ouagadougou, Burkina Faso) , , Drabo, Maxime Koiné , , Medah, Isaï , e , Barro, Nicolas , Sharma, Sumit , Svensson, Lennart , Nordgren, Johan
    Journal of medical virology v.90 no.9 ,pp. 1453 - 1460 , 2018 , 0146-6615 ,

    초록

    Burkina Faso introduced rotavirus vaccine (RotaTeq) to the national immunization program in November 2013. This study describes the detection rates, clinical profiles, and molecular epidemiology of rotavirus and norovirus (NoV) infections among children

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  7. [해외논문]   Phylogenetic analysis of human G9P[8] rotavirus strains circulating in Jiangsu, China between 2010 and 2016  

    Xu, Cheng (Laboratory Medicine Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China) , Fu, Jianguang (Key Lab of Enteric Pathogenic Microbiology, Ministry of Health, Department of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China) , Ai, Jing (Key Lab of Enteric Pathogenic Microbiology, Ministry of Health, Department of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China) , Zhang, Jun (Department of Acute Infectious Disease Control and Prevention, Suzhou Center for Disease Control and Prevention, Suzhou, China) , Liu, Cheng (Department of Acute Infectious Disease Control and Prevention, Suzhou Center for Disease Control and Prevention, Suzhou, China) , Huo, Xiang (Key Lab of Enteric Pathogenic Mic) , Bao, Changjun , Zhu, Yefei
    Journal of medical virology v.90 no.9 ,pp. 1461 - 1470 , 2018 , 0146-6615 ,

    초록

    Rotavirus A (RVA) is the leading cause of acute viral gastroenteritis in children under 5 years of age worldwide. G9P[8] is a common RVA genotype that has been persistently prevalent in Jiangsu, China. To determine the genetic diversity of G9P[8] RVAs, 7 representative G9P[8] strains collected from Suzhou Children’s Hospital between 2010 and 2016 (named JS2010‐JS2016) were analyzed through whole‐genome sequencing. All evaluated strains showed the Wa‐like constellation G9‐P[8]‐I1‐R1‐C1‐M1‐A1‐N1‐T1‐E1‐H1. Furthermore, phylogenetic analysis revealed that the VP7 genes of all strains clustered into lineage G9‐III and G9‐VI. With the exception of strain JS2012 (P[8]‐4), the VP4 sequences of all strains belonged to the P[8]‐3 lineage. Sequencing further revealed that amino acid substitutions were present in the antigenic regions of the VP7 and VP4 genes of all strains. Moreover, there were multiple substitutions in antigenic sites I and II of the nonstructural protein 4 (NSP4) genes, whereas the other NSP genes were relatively conserved. In conclusion, our phylogenetic analysis of these 7 G9P[8] strains suggests that RVA varied across regions and time. Therefore, our findings suggest that continued surveillance is necessary to explore the molecular evolutionary characteristics of RVA for better prevention and treatment of acute viral gastroenteritis.

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  8. [해외논문]   Molecular typing and whole genome next generation sequencing of human adenovirus 8 strains recovered from four 2012 outbreaks of keratoconjunctivitis in New York State  

    Lamson BS, Daryl M. (Wadsworth Center, New York State Department of Health, Albany, New York ) , Kajon, Adriana E. (Lovelace Respiratory Research Institute, Infectious Disease Program, Albuquerque, New Mexico ) , Shudt, Matthew (Wadsworth Center, New York State Department of Health, Albany, New York ) , Quinn, Monica (Healthcare Epidemiology and Infection Control Program, New York State Department of Health, Albany, New York ) , Newman, Alexandra (Bureau of Communicable Disease Control, New York State Department of Health, Albany, New York ) , Whitehouse, Joan (Healthcare Epidemiology and Infection Control Program, New York State Department of Health, New Rochelle, New York ) , Greenko, Jane (Healthcare Epidemiology and Infection Control Program, New York State Department of Health, Long Island, New York ) , Adams, Eleanor (Healthcare Epidemiology and Infection Control Program, New York State Department of Health, New Rochelle, New York ) , St. George, Kirsten (Wadsworth Center, New York State Department of Health, Albany, New York)
    Journal of medical virology v.90 no.9 ,pp. 1471 - 1477 , 2018 , 0146-6615 ,

    초록

    Ocular infections caused by human adenovirus (HAdV) are highly contagious. The most severe are usually caused by members of species HAdV‐D (types HAdV8, 19, 37, 53, 54, and 56) and can manifest as epidemic keratoconjunctivitis (EKC), often resulting in prolonged impairment of vision. During the early months of 2012, EKC outbreaks occurred in neonatal intensive care units (NICUs) in 3 hospitals in New York State (New York and Suffolk Counties). A total of 32 neonates were affected. For 14 of them, HAdV8 was laboratory‐confirmed as the causative agent. Nine healthcare workers were also affected with 3 laboratory‐confirmed, HAdV‐positive EKC. A fourth EKC outbreak was documented among patients attending a private ophthalmology practice in Ulster County involving a total of 35 cases. Epidemiological linkage between the neonatal intensive care unit outbreaks was demonstrated by molecular typing of virus isolates with restriction enzyme analysis and next generation whole genome sequencing. The strain isolated from the ophthalmology clinic was easily distinguishable from the others by restriction enzyme analysis.

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  9. [해외논문]   Histone deacetylase inhibitor chidamide promotes reactivation of latent human immunodeficiency virus by introducing histone acetylation  

    Kuai, Qiyuan (Department of Blood Products and Substitutes, Beijing Institute of Transfusion Medicine, Beijing, China) , Lu, Xiaofan (STD/HIV Research Laboratory, Beijing You‐An Hospital, Capital Medical University, Beijing, China) , Qiao, Zhixin (Department of Blood Products and Substitutes, Beijing Institute of Transfusion Medicine, Beijing, China) , Wang, Rui (Beijing Key Laboratory for HIV/AIDS Research, Beijing You‐An Hospital, Capital Medical University, Beijing, China) , Wang, Yanbing (Department of Blood Products and Substitutes, Beijing Institute of Transfusion Medicine, Beijing, China) , Ye, Sanxian (Department of Blood Products and Substitutes, Beijing Institute of Transfusion Medicine, Beijing, China) , He, Min (Department of Blood Products and Substitutes, Beijing Institute of Transfusion Medicine, Beijing, China) , Wang, Yu , Zhang, Tong , Wu, Hao , Ren, Suping , Yu, Qun
    Journal of medical virology v.90 no.9 ,pp. 1478 - 1485 , 2018 , 0146-6615 ,

    초록

    Highly active antiretroviral therapy can reduce the human immunodeficiency virus (HIV) viral load in the plasma to undetectable levels. However, because of the presence of latent HIV reservoirs, it is difficult to completely eradicate HIV in infected patients. Our objective was to assess the potency of chidamide, a novel histone deacetylase inhibitor recently approved for cancer treatment by the China Food and Drug Administration, to reactivate latent HIV‐1 via histone acetylation. Viral reactivities of chidamide were accessed in 2 latent HIV pseudotype virus cell reporter systems (J‐Lat Tat‐green fluorescent protein clone A72 and TZM‐bl), a latently infected full‐length HIV virus cell system (U1/HIV), and resting CD4 + T cells from 9 HIV‐infected patients under highly active antiretroviral therapy with undetectable viral load. Chidamide was able to increase HIV expression in each cell line, as evidenced by green fluorescent protein, luciferase activity, and p24, as well as to reactivate latent HIV‐1 in primary CD4 + T cells of HIV‐infected patients. Histone acetylation adjacent to the HIV promoter in A72 cells was determined by chromatin immunoprecipitation. Chidamide was able to increase histone H3 and H4 acetylation at the HIV promoter. In brief, chidamide induced the reactivation of latent HIV in pseudotype virus reporter cells, latently infected cells, and primary CD4 + T cells, making this compound an attractive option for future clinical trials.

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  10. [해외논문]   Performance comparison of deep sequencing platforms for detecting HIV‐1 variants in the pol gene  

    Nicot, Florence (Laboratoire de Virologie, CHU de Toulouse, Hôpital Purpan, Toulouse, France) , Jeanne, Nicolas (Laboratoire de Virologie, CHU de Toulouse, Hôpital Purpan, Toulouse, France) , Raymond, Sté (Laboratoire de Virologie, CHU de Toulouse, Hôpital Purpan, Toulouse, France) , phanie (Laboratoire de Virologie, CHU de Toulouse, Hôpital Purpan, Toulouse, France) , Delfour, Olivier (Laboratoire de Virologie, CHU de Toulouse, Hôpital Purpan, Toulouse, France) , Carcenac, Romain (Laboratoire de Virologie, CHU de Toulouse, Hôpital Purpan, Toulouse, France) , Lefebvre, Caroline (Laboratoire de Virologie, CHU de Toulouse, Hôpital Purpan, Toulouse, France) , Sauné (INSERM, U1043, Toulouse, France) , , Karine (Laboratoire de Virologie, CHU de Toulouse, Hôpital Purpan, Toulouse,) , Delobel, Pierre , Izopet, Jacques
    Journal of medical virology v.90 no.9 ,pp. 1486 - 1492 , 2018 , 0146-6615 ,

    초록

    The present study compares the performances of an in‐house sequencing protocol developed on MiSeq, the Sanger method, and the 454 GS‐FLX for detecting and quantifying drug‐resistant mutations (DRMs) in the human immunodeficiency virus polymerase gene (reverse transcriptase [RT] and protease [PR]). MiSeq sequencing identified all the resistance mutations detected by bulk sequencing (n = 84). Both the MiSeq and 454 GS‐FLX platforms identified 67 DRMs in the RT and PR regions, but a further 25 DRMs were identified by only one or other of them. Pearson’s analysis showed good concordance between the percentage of drug‐resistant variants determined by MiSeq and 454 GS‐FLX sequencing ( ρ = .77 .77, P

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