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저널/프로시딩 상세정보

권호별목차 / 소장처보기

H : 소장처정보

T : 목차정보

大韓皮膚科學會誌 = Korean journal of dermatology 20건

  1. [국내논문]   CD8 Expression in Mycosis Fungoides  

    Um, Sung Hee , Oh, Chee Won
    大韓皮膚科學會誌 = Korean journal of dermatology v.42 no.12 ,pp. 1525 - 1530 , 2004 , 0494-4739 ,

    초록

    BACKGROUND: Mycosis fungoides (MF) is malignant proliferation of T-helper memory lymphocyte, and only a minority of cases present with other phenotypes such as CD3+, CD4-, CD8+ or CD3+, CD8+. Primary cutaneous CD8+ epidermotropic cytotoxic T-cell lymphoma is known to represent aggressive course. OBJECTIVES: The purpose of this study was to define the CD8 expression in mycosis fungoides and clinical characteristics of CD8+ MFs. In addition, we also studied whether the presence of CD8+ tumor-infiltrating lymphocytes (TIL) had any impact on prognosis of the disease. Patients & METHODS: We retrospectively analyzed 9 patients with MFs by chart review and medical records including age, location, disease duration and patients prognostic features. We also observed CD4 and CD8 expression through the immunohistochemical staining on paraffin-embedded tissue. RESULTS: All the patients, including the present study, showed positive response to CD8 immunohistochemical staining. CD8+ TIL was found in upper dermis (100.0%) of all patients. Two patients had lesion with CD4 TIL more strongly stained than with CD8 TIL, 2 patients with CD8 more than CD4, and the rest showed equally stained lesion. There were no significant differences among the location of CD8 TIL, the density of staining, CD4 TIL/ CD8 TIL and disease prognosis. On long-term follow-up, these results described herein showed that patients with CD8+ cutaneous T-cell lymphomas enjoyed good prognosis. CONCLUSIONS: Our results revealed that all MFs showed positive response to CD8 immunohistochemical staining. Our CD4+ and CD8+ MFs showed clinical features similar to those reported CD4+ and CD8- MFs and enjoyed good prognosis rather than aggressive clinical behavior on long-term clinical follw-up.

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  2. [국내논문]   A Clinical Study on Herpes Zoster During the Last 10-Year-Period (1994-2003)  

    Park, Seok Yeol , Kim, Joo Yong , Kim, Chang Duk , Kim, Chang Wook , Lee, Kyu Suk
    大韓皮膚科學會誌 = Korean journal of dermatology v.42 no.12 ,pp. 1531 - 1535 , 2004 , 0494-4739 ,

    초록

    BACKGROUND: Herpes zoster is a common dermatologic disease characterized by unilateral pain and vesicular eruptions. The incidence of herpes zoster seems to be increasing recently. OBJECTIVE: The aim of this study was to elucidate the epidemiology and the clinical characteristics of herpes zoster. METHOD: During the 10-Year-Period from Jan. 1994 to Dec. 2003, 1089 patients with herpes zoster were evaluated in regard to annual incidence, age, sex, and monthly, seasonal, and dermatomic distributions. Patients with herpes zoster were further assessed concerning associated diseases and complications. RESULT: 1. The annual incidence averaged over the 10 years was 2.98% (1089 cases of total 36, 531 outpatients) which is increasing recently. 2. Herpes zoster was seen most frequently in the 7th decade of life, and the ratio of male to female was 1: 1.43. 3. There was no marked monthly or seasonal variation in the incidence of herpes zoster. 4. The most common dermatomic distribution was thoracic dermatome (49.6%), followed by trigeminal (19.5%), cervical (14.9%), lumbar (7.9%), sacral (5.3%) and multiple dermatomic involvement (2.8%). 5. Associated diseases of herpes zoster were observed in 398 patients (36.5%), which included hypertension (12.6%), diabetus mellitus(7.9%), gastric ulcer (2.8%), chronic renal failure (1.7%), asthma(1.7%), angina pectoris (1.6%), malignancy (0.6%) and so on. 6. The most common complication of herpes zoster was postherpetic neuralgia (7.4%), followed by eye complication (3.2%), secondary bacterial infection (1.8%), scar formation (0.8%), neurogenic bladder (0.4%), and Ramsay-Hunt syndrome (0.2%). CONCLUSION: Most of the results described in this study are similar to those previously reported, except for a higher incidence in female. The recent annual incidence of herpes zoster shows a tendency to increase.

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  3. [국내논문]   Clinical Study on 3, 123 Psoriatic Patients: Observation of the patients registered for the past 20 years (1982-2002) at Seoul National University Hospital Psoriasis Clinic  

    Youn, Jai Il , Jo, Seong Jin
    大韓皮膚科學會誌 = Korean journal of dermatology v.42 no.12 ,pp. 1536 - 1542 , 2004 , 0494-4739 ,

    초록

    BACKGROUND: Psoriasis is a chronic relapsing disorder which shows variable clinical features. A study of a large number of patients may unravel the epidemiological and clinical features of psoriasis. OBJECTIVE: Our purpose was to investigate the epidemiological data and clinical features of psoriasis in a large number of Korean patients. METHODS: Epidemiological and clinical data, with particular reference to the extent and activity of the condition, in 3, 123 newly psoriatic patients registered between 1982 and 2002 were collected and analyzed. RESULTS: The results can be summarized as follows: 1. In our psoriatic patients, 54.4% were male and 45.6% were female (1.2: 1). 2. The age of most frequent onset was in the third decade of life (31.8%). The peak age of onset in male was in their twenties, while it was in their teens in female patients, indicating an earlier onset in female. 3. Totally, 67.2% of patients developed psoriasis before their 30 years of age. The age of onset was earlier than 30 years in 62.7% of male patients, whereas in 72.5% of female patients. 4. Family history was observed in 25.8% of patients. 5. With reference to the extent of psoriasis, 37.5% of patients were mild cases whereas 45.3% were moderate and 17.2% were severe. 6. With reference to the activity, 41.5% of patients were mild cases, while 31.6% were moderate and 26.9% were severe. 7. The most common morphological features were nummular type (58.7%), followed by large plaque type (25.9%), and guttate type (10.3%). 8. Nail involvement was observed in 27.0% of patients. CONCLUSION: We investigated the epidemiological and clinical features of psoriasis in a large number of patients. These data one expected to be useful as references in the future.

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  4. [국내논문]   Effects of Substance P on the Expression of Various Factors to control Hair Growth in Human Hair Follicle Culture  

    Oh, Tak Heon , Lee, Eun Young , Lee, Won Soo
    大韓皮膚科學會誌 = Korean journal of dermatology v.42 no.12 ,pp. 1543 - 1551 , 2004 , 0494-4739 ,

    초록

    BACKGROUND: Among constituents of the skin, hair follicle is an organ where nerve fibers with the most highest density are distributed. Recently, it has been reported that neuropeptides, which are secreted by nerve fibers, have important roles in the hair growth and hair cycle change, and that, the expression of various growth factors and apoptosis-related molecules are important in the hair growth and hair cycle change. Therefore, it was thought of import to analyse the relationship between the effect of neuropeptides and the expression of various factors to control hair growth in the hair follicle and hair follicle cells. OBJECTIVE: The purpose of this study was to investigate the relationship between the effect of neuropeptides and the expression of various hair growth-related factors at the level of hair follicle after pretreatment of cultured hair follicles and dermal papilla cells with SP. METHODS: Normal human scalp samples were obtained, and anagen hair follicles and dermal papilla cells were isolated and were cultured in Dulbeco's Modified Eagle's Medium (DMEM) with several combination of supplements in an atmosphere of 5% CO2/95% air incubator. We divided the culture plates into two groups; i.e. control group (DMEM only) and SP group (10-6M SP dissolved in DMEM). The results were evaluated by measuring linear hair growth and hair follicle morphology under a light microscope. Also, after pretreatment of cultured hair follicle and dermal papilla cells with SP, we examined changes of expression of hair growth factors (FGF-7, IGF-1, VEGF), hair growth-inhibitory factors (IL-1alpha, IL-1beta), and apoptosis-related molecules (p53, caspase-3). RESULTS: The following results were obtained. 1. SP did not have any statistically significant effect on the rate of linear hair growth in cultured hair follicles. However, it prolonged the anagen stage of hair cycle. 2. In hair follicles, the expression of FGF-7, a hair growth factor, was increased more than control, while the expression of caspase-3, an apoptosis-related molecule, was decreased more than control. Also, morphological changes as well as the changes of expression of hair growth factors and apoptosis-related molecules were not found in dermal papilla cells. However, the expression of IL-1beta, a hair growth-inhibitory factor, was decreased more than control. CONCLUSION: We can conclude from the results that SP has growth-stimulatory effect and especially prolongs the duration of anagen phase without affecting the rate of linear hair growth. Also, in hair follicles and dermal papilla cells, SP shows hair growth-stimulatory effect at the molecular levels.

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  5. [국내논문]   Recurrent Annular Erythema in the Patients with Sj gren's Syndrome and/or Lupus Erythematosus-like Features  

    Yoon, Ho Joon , Chung, Jin Ho , Cho, Kwang Hyun , Lee, Ai Young
    大韓皮膚科學會誌 = Korean journal of dermatology v.42 no.12 ,pp. 1552 - 1558 , 2004 , 0494-4739 ,

    초록

    BACKGROUND: Recurrent annular erythema associated with anti-Ro (SSA) or anti-La (SSB) antibodies has been recognized as a unique cutaneous manifestation of Sj gren's syndrome or Sj gren's syndrome/SLE overlap syndrome in Orientals. OBJECTIVE: The purpose of this study was to evaluate the clinical, histological and serological aspects of recurrent annular erythema in the korean patients with Sj gren's syndrome and/or lupus erythematosus-like features. METHODS: This clinical investigation was carried out on 6 outpatients with this disorder who had visited Department of Dermatology, Seoul National University Hospital, from January 1996 to December 2003. RESULTS: These patients (four females, two males; range of age, 24-60 years, median 45 years) had relatively well demarcated annular erythematous plaques mainly on trunk and extremities. Two-thirds of the patients were anti-Ro positive and one-third was anti-La positive. Biopsy specimens revealed a moderate degree of perivascular and periappendageal lymphocytic infiltration throughout dermis. Other features to suggest LE were not demonstrated. Four patients were treated with oral hydroxychloroquine with good response. CONCLUSION: Although all 6 patients showed annular erythema associated with anti-Ro or anti-La antibodies, only two could be diagnosed as Sj gren's syndrome/SLE overlap syndrome. The other four presented with LE-like features such as photosensitivity, nephropathy and arthralgia.

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  6. [국내논문]   Expression of Human beta Defensin-2 in HaCaT Cell by Lipoteichoic Acid and Peptidoglycan  

    Kim, Ji Eun , Jeong, Mi Sook , Kim, Myeung Nam , Hong, Chang Kwun , Ro, Byung In , Seo, Seong Jun
    大韓皮膚科學會誌 = Korean journal of dermatology v.42 no.12 ,pp. 1559 - 1565 , 2004 , 0494-4739 ,

    초록

    BACKGROUND: Defensin, a major family of antimicrobial peptides, is small cationic, cysteine rich peptides with wide range of antimicrobial activity against Gram negative and Gram positive bacteria, fungi, yeast, and virus. Expression of human defensin-2 is upregulated by bacteria, virus, fungus and pro-inflammatory cytokines. However, this peptide was found to be only bacteriostatic, but not bactericidal, against the Gram positive bacteria. OBJECTIVE: To evaluate human defensin-2 (hBD-2) expression after exposure of human skin keratinocytes to the cell wall component of Gram positive bacteria such as lipoteichoic acid (LTA) and peptidoglycan(PEN), and to compare quantitatively the amount of expression with that after their exposure to the cell wall component of Gram negative bacteria. METHODS: Expression of hBD-2 was measured by reverse transcription polymerase chain reaction (RT-PCR), Western blotting, and immunohistochemistry(IHC). RESULTS: 1. In RT-PCR results, the amount of hBD-2 expression after exposure to LPS was larger than those of PEN and LTA at 6 and 12 hours (p=0.02). At 24 hours, hBD-2 expression showed a peak in PEN stimulated group (p=0.09). 2. In Western blot analysis, hBD-2 expressions, when treated with PEN and LTA, were stronger than that treated with LPS at 6 and 12 hours. 3. In IHC, hBD-2 was stained much stronger in LPS stimulated group than PEN or LTA stimulated groups at 12 hours. CONCLUSION: Our study demonstrated that exposure of human skin keratinocytes to the cell wall components of Gram positive bacteria such as LTA and PEN triggered production of hBD-2 in addition to the cell wall component of Gram negative bacteria such as LPS, however, the amounts of expression were relatively stronger in LPS treated group.

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  7. [국내논문]   Phototherapy of Acne Vulgaris with Low Level Narrow Band Red Light (680 nm)  

    Lee, Bo Hyun , Kim, Hye One , Han, Hee Jin , Kang, Kweon Soo , Park, Chun Wook , Lee, Cheol Heon , Houh, Won
    大韓皮膚科學會誌 = Korean journal of dermatology v.42 no.12 ,pp. 1566 - 1573 , 2004 , 0494-4739 ,

    초록

    BACKGROUND: It has been reported that the phototherapy with blue light (415 nm) or a mixed blue and red light (415 nm and 660 nm) is effective in the treatment of acne vulgaris. however, the effects of red light on acne vulgaris have not been investigated. OBJECT: To examine the effects of red light (680 nm) on patients with moderate acne vulgaris. METHODS: Patients treated their skin by themselves, using portable light source (680 nm), and irradiation was performed for 7 minute twice daily. Each patient was evaluated every 2 weeks with Burton scale and the numbers of papules and pustules. After 6 weeks, the degrees of satisfaction of patients and physicians were assessed. RESULT: Therapy with red light significantly decreased the numbers of papules and pustules (p

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  8. [국내논문]   A Case of Acrokeratoelastoidosis  

    Park, Chang Ook , Park, Junsu , Kim, You Chan , Lee, Ju Hee
    大韓皮膚科學會誌 = Korean journal of dermatology v.42 no.12 ,pp. 1574 - 1577 , 2004 , 0494-4739 ,

    초록

    Acrokeratoelastoidosis (AKE) is a rare skin disorder initially described by Costa, which is inherited by autosomal dominant, but also may be sporadic. Clinically, it consists of small, firm papules with occasional keratosis or umbilication, characteristically along the margins of hands and feet. Histopathologically, it shows hyperkeratosis, acanthosis in the epidermis and fragmentation and rarefaction of elastic fibers-elastorrhexis-in the dermis. A 32-year-old man presented with multiple papules along the border of the hands and feet, and from histopathology, AKE was diagnosed. Herein we report a case of acrokeratoelastoidosis and review the clinical and histopathologic features, etiology, differential diagnosis and treatment.

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  9. [국내논문]   A Case of Allergic Contact Dermatitis Due to EMLA(R)  

    Lee, Sang Hun , Ryu, Jeong Ho , Kim, Chul Woo , Kim, Kwang Ho , Kim, Kwang Joong
    大韓皮膚科學會誌 = Korean journal of dermatology v.42 no.12 ,pp. 1578 - 1580 , 2004 , 0494-4739 ,

    초록

    EMLA is a eutectic mixture of 2.5% lidocaine and 2.5% prilocaine for topical anesthesia and commonly used to avoid pain in cutaneous surgery or vascular punctures. We describe a 27-year-old female who had lower extremity hair removed by laser treatment after EMLA application and subsequently developed of adverse reactions, including itching, erythema and edema. Patch testing with EMLA showed allergy reaction at day2 and day4.

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  10. [국내논문]   A Case of Multiple Lentigines Sydrome with a Family History of Multiple Lentigines  

    Kim, So Jin , Seo, Phil Seung , Yoon, Nyung Hoon , Park, Seok Don
    大韓皮膚科學會誌 = Korean journal of dermatology v.42 no.12 ,pp. 1581 - 1584 , 2004 , 0494-4739 ,

    초록

    Multiple lentigines syndrome is an autosomal dominant disorder of variable penetrance and expressivity. LEOPARD has been used to describe the main features of the syndrome, including lentigines, electrocardiographic abnormalities, ocular hypertelorism, pulmonary stenosis, abnormalities of genitalia, retardation of growth and deafness. We describe a case of multiple lentigines syndrome with a family history of multiple lentigines. A 15-year-old boy presented with multiple brown macules and patches on the whole body, which had developed since the age of 3. He also had hypertrophic cardiomyopathy, EKG abnormalities and retarded growth. His maternal grandfather, maternal uncle and mother also presented with multiple brown macules scattered over the body. The biopsy specimen taken from the macule revealed elongated rete ridges, increased melanin deposition and increased number of melanocytes.

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