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저널/프로시딩 상세정보

권호별목차 / 소장처보기

H : 소장처정보

T : 목차정보

大韓皮膚科學會誌 = Korean journal of dermatology 31건

  1. [국내논문]   The Clinical Effect of 5% Imiquimod Cream in the Treatment of Verruca Plana  

    Lee, Un Ha , Choi, Jung Chul , Chun, Duk Kyu
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.1 ,pp. 1 - 5 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Despite numerous therapeutic options, the treatment of verruca plana remains unsatisfactory for both patients and physicians. Imiquimod, a novel topical immune response modifier, has been successfully used for the treatment of external anogenital warts. OBJECTIVE: The purpose of this study was to investigate the efficacy of imiquimod in treatment of verruca plana. METHOD: Fifteen patients with verruca plana were treated with 5% imiquimod cream that was self-applied 3 times a week and left in place overnight. Assessment for responses and side effects was performed every 2 weeks until clinical cure or up to 12 weeks. RESULTS: 10 of 15 (66.7%) patients achieved a excellent result (>75% improvement), and 11 (73%) patients achieved a good result (>50% improvement). With regard to the location of the lesions, 10 of 12 (83%) patients with lesions on the face and neck achieved a clear result (>95% improvement), but only 2 of 7 (28%) patients with lesions on the extremities achieved a clear result. Local inflammatory reactions were the most common adverse events, however, they were generally mild and transient. CONCLUSION: 5% imiquimod cream, applied by the patient, is an effective treatment modality for verruca plana.

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  2. [국내논문]   Quality of Life of Acne Patients  

    Ahn, Bong Kyun , Lee, Sang Ju , Namkoong, Ki , Chung, Yae Lee , Lee, Seung Hun
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.1 ,pp. 6 - 14 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Although acne is extremely prevalent, few studies have focused on what the patient with acne vulgaris experiences. Furthermore, despite recent advances in the accurate measurement of health outcomes, few studies have discussed the influence of acne on discrete aspects of patients' experiences such as their quality of life. OBJECT: To determine the influence of acne vulgaris on the quality of life of adult dermatology outpatients, we performed cross-sectional and longitudinal questionnaire study. METHOD: Sixty patients with acne vulgaris attending appointments with their dermatologists. Findings using Skindex, a validated 29-item instrument to measure the effects of skin disease on patients' quality of life. Results are reported as 3 scale scores (functioning, emotions, and symptoms) and a composite score (average scale score). In addition, dermatologists rated the clinical severity of patients' skin disease. Higher Skindex scores indicate greater effects on quality of life. RESULTS: Patients with acne experienced functioning and emotional effects from their skin disease comparable with those of patients with psoriasis, but experienced fewer symptoms (for patients with acne and psoriasis, respectively, Skindex functioning scores of 14.9 and 22.8 [p=0.08]; emotion scores, 39.2 and 38.9 [p=0.95]; and symptoms scores, 29.5 and 42.1 [p

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  3. [국내논문]   Expression of Cyclooxygenase-2 in Malignant Melanoma  

    Jung, Do Sang , Oh, Chang Keun , Jang, Ho Sun , Kim, Moon Bum , Kwon, Kyung Sool
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.1 ,pp. 15 - 21 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Several reports have suggested that the expression of cycloxygenase-2 (COX-2) is related to carcinogenesis and the prognosis of cancer. However, few studies have demonstrated the increased expression of cyclooxygenase-2 (COX-2) in malignant melanoma. Furthermore the role of COX-2 in malignant melanoma has not been fully established. OBJECTIVE: The aims of this study were to investigate COX-2 expression in malignant melanomas and to also find the relationship between the prognostic factors of malignant melanoma and COX-2 expression. METHODS: We performed immunohistochemical staining on paraffin specimens obtained from patients who had undergone a skin biopsy at the Department of Dermatology, Pusan National University Hospital. The specimens were composed of primary cutaneous malignant melanoma (n=17) and nevomelanocytic nevus (n=7). We analyzed the expressions of COX-2 in malignant melanoma with relation to their clinicopathologic type, Breslow thickness, Clark level, lymph node metastasis and TNM stage. RESULTS: COX-2 was expressed in 88.2% (15/17) of the malignant melanoma, but in none of the nevomelanocytic nevus. In malignant melanoma, COX-2 expression was positively related to nodular type, Breslow thickness, Clark level and TNM stage, but not to lymph node metastasis. CONCLUSION: The above results indicate that expressed COX-2 is in malignant melanoma, suggesting that COX-2 expression may contribute to the carcinogenesis of melanocytes.

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  4. [국내논문]   Study of Clinical Features of Cutaneous Side Effects Associated with ZD 1839  

    Jang, Yong Hyun , Choi, Jin Hyuk , Lim, Ho Yeong , Lee, Eun So
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.1 ,pp. 22 - 28 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: ZD1839 (Iressa(R)Gefitinib) is an orally active, selective epidermal growth factor (EGF) receptor tyrosine kinase inhibitor that blocks signal production pathways in cell proliferation. It is currently used in the treatment of advanced stage non-small cell lung cancer. Cutaneous side effects commonly associated with ZD 1839 treatment include acneiform eruption, dry skin and hair growth abnormalities. Cutaneous eruptions result from direct interference with functions of EGF receptor signaling in the skin. OBJECTIVE: The purpose of our study was to investigate the clinical features of cutaneous side effects of ZD 1839 in Korean with literature review. We also analysed the relationship between skin rash severity, onset and objective tumor response. METHOD: We retrospectively reviewed medical records and the histologic materials of 23 Korean patients who had been treated with ZD 1839 at Ajou University Hospital from March 2002 to September 2003 . RESULTS: The results are summarized as follows. 1. The most common cutaneous side effect was acneiform skin rash (56%) which is a well known complication of ZD 1839. 2. Acneiform eruptions were easily controlled by oral antibiotics, such as minocycline and topical retinoid ointment. 3. The second common side effect was dry scaly skin (43%). 4. We also found acute paronychia, finger tip desquamation, alopecia and intertrigo. 5. The severity of the skin rash correlated well with the treatment response of ZD 1839. 6. When the skin rash appeared within 1 week after taking ZD 1839, the skin rash was severe, and the tumor responded well to the ZD 1839. CONCLUSION: The results of this study suggest that acneiform eruption and dry skin are the most common cutaneous side effects of ZD 1839. The association between rash severity and onset of tumor response suggests that the rash may serve as a marker of response to ZD1839 therapy and may be used to guide treatment to obtain optimal response. However, further prospective studies on the potentially important association between rash severity or onset and outcome of treatment with ZD 1839 are needed.

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  5. [국내논문]   Effectiveness of Amniotic Membrane Patch in the Treatment of Chronic Ulcers  

    Kim, Hong Seok , Song, Ki Hoon , Park, Woo Chan , Kim, Ki Ho
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.1 ,pp. 29 - 36 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: The main goal in the management of an open wound is to obtain a clean and closed wound in the shortest time. Open wounds, including chronic and acute ulcers, occur frequently, and are painful and difficult to heal. We evaluated the usefulness of human amniotic membrane for management of ulcers, due to its easy accessibility, negliable cost and healing properties. OBJECTIVE: The aim of this study was to confirm the findings on the use of human amnion in the treatment of post-phlebitic, post-burn chronic ulcers and postoperative wound defects. METHODS: We treated 12 patients with non-healing ulcers, and postoperative wound defects, using human amniotic membrane. RESULTS: Most patients experienced immediate and impressive relief of pain after application of the amniotic membrane. The ulcer beds treated with amnion were vascular and filled with granulation tissue. Human amniotic membranes kept the wounds bacteriologically clean, thus allowing spontaneous closure to occur and reduced the time required for healing and convalescence. CONCLUSIONS: Human amniotic membrane was successfully used as a biological dressing for treating ulcerations, including chronic ulcers and postoperative wound defects. It can serve as either a permanent therapy or as a temporary measure until the inflammation subsides.

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  6. [국내논문]   Isolation of Dermatophytes from Patients with Tinea Pedis Using the Foot-press Method  

    Lee, Ho Chung , Suh, Moo Kyu , Ha, Gyoung Yim
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.1 ,pp. 37 - 44 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Although tinea pedis is one of the most prevalent diseases caused by dermatophytes, there have been few studies about distribution of dermatophytes on infected soles for this disease in Korea. OBJECTIVE: The purpose of the study was to investigate the distribution of dermatophytes on infected sole using the new direct culture method (Foot-press method). METHODS: The infected soles of 39 patients were directly pressed onto Sabouraud's dextrose agar with cycloheximide prepared in a large culture dish for a few seconds. The culture media were then incubated at 25degrees C for 1-4 weeks. RESULTS AND CONCLUSION: 1. Dermatophyte colonies were isolated from twenty-eight patients (71.8%). 2. Twenty-four of the isolated dermatophytes were Trichophyton (T.) rubrum (85.7%), and the rest were T. mentagraphytes (14.3%). 3. The number of isolated colonies from each patient range from 1 to 102 (Mean+/-SD, 12.8+/-20.7). Three isolated colonies were most common. 4. The isolation frequencies were higher in the patients of keratotic type and in those with tinea unguium (p

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  7. [국내논문]   The Clinical Manifestations and Etiologic Factors of Patients with Pigmented Purpuric Dermatoses  

    Cho, Jae Hoon , Lee, Jeong Deuk , Kang, Hoon , Cho, Sang Hyun
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.1 ,pp. 45 - 52 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Pigmented purpuric dermatoses comprise a group of benign dermatoses that are clinically characterized by pinpoint petechiae and purpura on the hyperpigmented base, and histologically by capillaritis without any fibrinoid necrosis of the vessel. The etiology of pigmented purpuric dermatoses is unknown. Identification of triggering factors will contribute to find out the pathogenesis of the pigmented purpuric dermatoses. OBJECTIVES: The aim of this study was to investigate the clinical manifestations of pigmented purpuric dermatoses and to elucidate the relationship between the causative factors and clinical manifestation of pigmented purpuric dermatoses. METHODS: Clinical observation and review of medical records, photographs, and histopathologic specimens were made by analyzing 37 cases of patients with pigmented purpuric dermatoses who visited Our Lady of Mercy Hospital from 1995 to 2003. The present medical status of each patient was surveyed by phone and detailed reviews of the clinical records included attention to clinical manifestations, possible etiologic factors and coexisting diseases of each patient. The statistical methods used was one-way ANOVA test. RESULTS & CONCLUSIONS: The results were as follows; 1. Female to male ratio was 1.47: 1. The mean age at diagnosis was 45.6+/-17.2 years. 2. The mean duration of disease was 10.2+/-9.0 months, and the disease that localized to the lower limbs was in 75.7% of patients. 3. Of the 37 patients, 23 patients were of the Schambergs disease (62.2%), 11 patients were of the Majocchis disease (29.7%), 2 patients were of the Lichen aureus (5.4%), and one patient was of the Eczematid-like purpura of Ducas and Kapetanakis (2.7%). 4. The 37 patients were treated with topical or systemic steroid (73%), pentoxyfylline (10.8%), and there was no difference in the clinical course according to the treatment. Of the 37 patients, 18 patients had improvement or clearing of their lesions. 5. The etiologic factors identified were, orthostatic hypertension (21.6%), exercise (8.1%), metals (5.4%), NSAIDs (2.7%), heat (2.7%), and a wide spectrum of disease was present in patients with pigmented purpuric dermatoses. 6. The 14 of 22 patients without etiologic factors had medical problems, whereas 3 of 15 patients with etiologic factors had medical problems. The 5 of 15 patients with etiologic factors had clearance or improvement of their lesions, but 13 of 22 patients without etiologic factors had clearance or improvement of their lesions.

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  8. [국내논문]   Photodynamic Therapy of Actinic Keratoses Using 585nm Dye Laser and Variable Lights  

    Kim, Hong Seok , Song, Ki Hoon , Kim, Ki Ho
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.1 ,pp. 53 - 59 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Incohorenet lamps or pulsed/continuous wave lasers have effectively been used for photodynamic therapy (PDT). OBJECTIVE: To assess the safety and efficacy of the various light sources, such as halogen, xenon arc, and the 585nm pulsed dye laser, in photodynamic therapy for treatment of actinic keratosis. METHODS: PDT, using 5-aminolaevulinic acid (5-ALA), was used on 18 patients who had been diagnosed with actinic keratoses. A single treatment consisting of a topical application of 20% 5-aminolaevulinic acid for 4 hours, followed by halogen, xenon arch lamp and the 585nm pulsed dye laser was administered. RESULTS: Of the 227 lesions, 95/106 (89.6%), 68/77 (88.3%), and 39/44 (88.6%) lesions showed complete response to the halogen lamp, xenon arc lamp, and 595nm dye laser respectively, and 10/106 (9.4%), 9/77 (11.7%), and 5/44 (11.4%) lesions showed partial response to the above, respectively. Only one lesion (1.0%) showed no response to the halogen lamp. In all cases, cosmetic outcome was excellent, and anatomical function was preserved. Topical 5-ALA based PDT is an effective and useful treatment modality for various premalignant diseases, to the halogen lamp, xenon arc lamp, or 585nm pulsed dye laser were used. CONCLUSIONS: Treatment of actinic keratosis with various light sources, following topical application of 5-ALA is effective. However, advantages of the laser treatment may include recovery times, excellent postreatment cosmesis, and high efficacy rate.

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  9. [국내논문]   Squamous cell carcinoma of the finger and toe  

    Cho, Kwang Hyun , Yoon, Ho Joon , Choi, Chong Won , Kim, Mi Sun , Kim, Yeon Kyung , Moon, Sang Eun , Kim, Chul Woo , Paik, Goo Hyun
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.1 ,pp. 60 - 66 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Squamous cell carcinoma of the finger and toe is a relatively rare disorder which has often been misdiagnosed for years before definite diagnosis. Squamous cell carcinoma of the finger has usually been found to be associated with type 16 human papillomavirus (HPV). OBJECTIVES: To describe the clinical and histological features of 12 squamous cell carcinomas of the finger and toe, and to evaluate these lesions for the presence of HPV. METHOD: The clinical and histological features were reviewed. Immunohistochemical staining and PCR were performed in paraffin embedded tissue sections for detection of the presence of HPV infection. RESULTS: Patients presented with an erosive or a verrucous papule. Histologically, 2 lesions demonstrated bowenoid features, 9 lesions demonstrated well differentiated squamous cell carcinoma, and 1 lesion demonstrated verrucous carciroma-like features. By immunohistochenical staining and PCR, we could not demonstrate any evidence of HPV infection in any of the cases. The affected digit was amputated in 10 cases, and complete excision of the skin lesion was done in 2 cases. CONCLUSION: Squamous cell carcinoma of the finger and toe is not as rare as has been implied by early literature. It is important to carry out the skin biopsy from all recalcitrant lesions of the finger and toe.

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  10. [국내논문]   A Case of Actinomycosis of the Inguinal Area  

    Yi, Ji Hyun , Choi, Hyoun Sung , Kim, Han Uk , Ihm, Chull Wan
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.1 ,pp. 67 - 70 , 2005 , 0494-4739 ,

    초록

    Actinomycosis is a chronic bacterial infection characterized by suppurative, fibrosing inflammation, and sinus tracts draining sulfur granules. It usually involves the head, neck, thorax and abdomen. Actinomycosis involving the inguinal area is extremely rare. A 55-year-old man presented with an asymptomatic, erythematous, hard, nontender nodule in his left inguinal area. A biopsy taken from the nodule showed an abscess and sulfur granules in the dermis. Gram staining and methenamine silver staining demonstrated a mesh of branching rods. Cultures of the pus and tissue specimens failed to grow any organisms. Based on the histopathologic findings, we diagnosed this case as actinomycosis of the inguinal area and treated it with a surgical method.

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