본문 바로가기
HOME> 저널/프로시딩 > 저널/프로시딩 검색상세

저널/프로시딩 상세정보

권호별목차 / 소장처보기

H : 소장처정보

T : 목차정보

大韓皮膚科學會誌 = Korean journal of dermatology 31건

  1. [국내논문]   A Clinical Observation of Drug Hypersensitivity Syndrome and Serologic and Molecular Genetic Analyses of Human Herpesvirus-6 Reactivation  

    Kim, Jae Wang , Kim, Jin Seok , Kim, Kwang Joong
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.2 ,pp. 143 - 150 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Drug hypersensitivity syndrome (DHS) is a life-threatening reaction that appears after prolonged exposure to certain drugs. Unlike usual drug eruptions, DHS typically represents protracted a clinical course, slow resolution and a higher mortality rate. Recently, several studies have provided evidence to show that the reactivation of human herpesvirus-6 (HHV-6) is implicated in the pathogenesis of DHS. Until now, the study of the relationship of HHV-6 with DHS has rarely been presented in Korea. OBJECTIVE: We performed this study in order to determine the possibility of reactivation of HHV-6 in patients with DHS. METHODS: A clinical survey was performed retrospectively using the available medical records of 8 DHS cases. Concurrently, the histopathologic, serologic and molecular genetic analyses of the preserved specimens of the DHS patients were conducted, and the results were compared with 3 cases of another type of drug eruption. RESULTS: 1. Mean time of onset of clinical disease following the institution of a new drug was 21.8 days. Time from appearance of first skin lesion to the initiation of therapy (time to treat) was 6.1 days. The most common offending drugs were allopurinol (37.5%) and anti-convulsants (50%), including lamotrigine. The clinical outcome was as follows; recovery in 7 patients and transfer in one patient. 2. The clinical features of patients with DHS were as follows; widespread skin rash (100%), histopathologic findings compatible with drug hypersensitivity (100%), toxic hepatitis (100%), cholestatic injuries (37.5%), renal dysfunction (37.5%), drug fever (100%), leukocytosis (100%), peripheral eosinophilia (100%), lymphadenopathy (62.5%), and atypical lymphoid cells on a peripheral blood smear (62.5%). 3. Anti-HHV-6 IgM antibodies were detected in 2 patients (25%). Reactivation of HHV-6, as judged by a greater than 4-fold increase in anti-HHV-6 IgG titers, was detected in 5 cases (62.5%) of serum samples obtained 3 weeks after onset. 4. HHV-6B genome was detected by polymerase chain reaction (PCR) in 3 patients (37.5%) in the serum samples obtained 2 weeks after onset. At the second weeks, it was detected in the skin lesions of 4 patients (50%) and in the normal skin specimen of one case (12.5%). In one case of a patient without DHS, HHV-6B DNA was found by PCR in the serum sample at the second weeks. CONCLUSION: Several cases of DHS in Korea were associated with the reactivation of HHV-6. Accordingly, HHV-6 reactivation seems to play a potential role in the development of DHS in susceptible patients.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  2. [국내논문]   Reconstruction of Surgical Lip Defects after Malignant Tumor Excision  

    Kim, Hyung Su , Hwang, Eun Ju , Cho, Kwang Hyun , Kwon, Oh Sang , Moon, Sang Eun
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.2 ,pp. 151 - 157 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: The lips have an asethetic and functional importance. There are various types of lip defects, and these are mainly due to tumor excision. Although there are numerous techniques available to repair the lips, no universal reconstruction method is presently available, and reconstruction of lip defects are inherently difficult. OBJECTIVE: To report surgical reconstruction results of lip defects. METHOD: Our study involved eleven patients, who had visited our dermatologic surgery clinic between 1995 and 2003, and had been histopathologically diagnosed as having either a basal cell carcinoma or squamous cell carcinoma on the lips. The medical records were reviewed, and clinical features, surgical methods, and cosmetic and functional results were evaluated. RESULTS: Wedge resection, resection with W-plasty, the subcutaneous pedicle flap, and dual mucosal flap technique were used to repair lip defects surgically. The vermilion border was aligned well in all the patients, and a post-operative scar was not apparent. However, a microstomia developed in one patient. CONCLUSION: The dermatologic surgeon should be familiar with various reconstruction options for lip defects. An appropriate choice depends on the size, location and depth of the defect. Specific functional and aesthetic aspects of the lips should be taken into account when planning and performing an operation.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  3. [국내논문]   Histopathological and Immunohistochemical Study of Lichen Nitidus and Lichen Striatus  

    Woo, Sang Hyuk , Kye, Young Chul , Kim, Soo Nam
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.2 ,pp. 158 - 160 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Lichen nitidus and lichen striatus are often confused because they are thought to share similar clinical and histopathologic features. OBJECTIVE: The purpose of this study was to histopathologically and immunohistochemically evaluate the characteristic differences and common features between the two disorders. METHOD: Histopathological and immunohistochemical slides of 14 patients with lichen nitidus and 14 patients with lichen striatus were reviewed. Immunohistochemical staining with anti CD45RO, CD68, CD4, CD8 and CD20 antibodies was performed. RESULTS: 1) In lichen nitidus, the frequent histopathologic findings were liquefaction degeneration of the basal layer (100%), edema of the dermis within the areas of the infiltate (100%), and claw-like rete ridges (96.8%). 2) In lichen striatus, the frequent histopathologic findings were edema of the dermis within the areas of the infiltate (100%), liquefaction degeneration of the basal layer (92.9%), and perivascular inflammatory cell infiltrate (92.9%). 3) The majority of the cells in the infiltrate of lichen nitidus were T lymphocytes mixed with histiocytes. In most cases, CD4+ T lymphocytes predominated CD8+ T lymphocytes. 4) However, in lichen striatus, infiltrating cells in the dermis were composed dominantly of T lymphocytes, with a minority of histiocytes. CD8+ T lymphocytes were also found to outnumber CD4+ T lymphocytes. CONCLUSION: Our study did differentiate each disease as having distinctive characteristics and differences. Furthermore, the immunologic pathophysiology of lichen nitidus and lichen striatus was proved to be distinctive. Therefore, we conclude that these two diseases are not in the spectrum of the same disease, but separate disease entities which are indeed different from each other.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  4. [국내논문]   The Effects of Testosterone on Skin Barrier  

    Bak, Hana , Choi, Eung Ho , Lee, Kwang Gil , Hong, Seung Phil , Lee, Seung Hun , Ahn, Sung Ku
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.2 ,pp. 167 - 176 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Although there are no known gender-related differences in permeability barrier function in adults, estrogen accelerates whereas testosterone retards barrier development in fetal skin. However, there have been few studies concerning the effects of testosterone on the skin barrier. OBJECT: We evaluated the effects and mechanisms of testosterone on the skin barrier. METHODS: In this experiment, hairless mice were divided into three groups; sham-operated, castrated and testosterone-replacement castrated group. Testosterone was administered subcutaneously once a day for 7 days. We performed a skin biopsy at 7 days and performed hematoxyline-eosin staining, calcium-ion capture cytometry and the immunohistochemical examination of involucrin, loricrin, filaggrin and proliferating cell nuclear antigen (PCNA). The specimens were prepared for electron microscopy using RuO4 and OsO4 postfixation. RESULTS: The results were summarized as follows 1. Light microscopic findings of the testosterone-replacement castrated group showed apparent hyperkeratosis and acanthosis, not present in the sham-operated and castrated group. 2. Whereas the expression of involucrin, loricrin and filaggrin of immunohistochemical staining and in situ hybridization of the sham-operated and castrated group were normal, it was abnormal in the testosterone-replacement castrated group. 3. Labelling indices for PCNA in the sham-operated and castrated group were not statistically different, but the testosterone-replacement castrated group showed a marked increase of PCNA labeling index. 4. Wherease the calcium gradient was normal in the sham-operated and castrated group, it was distorted in the testosterone-replacement castrated group. Calcium deposition was increased through all layers of the epidermis and the calcium gradient disappeared in the testosterone-replacement castrated group. 5. Normal looking membrane structure was observed in the sham-operated and castrated group, but a membrane structure which appeared fragmented, incomplete lipid bilayer structures and prominent dilatation of lacunar domains were observed only in the testosterone-replacement castrated group. CONCLUSION: From the above results, it is concluded that there is a functional alteration of the epidermal barrier induced by testosterone, including the formation of an abnormal cornified envelope and also incomplete lipid synthesis.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  5. [국내논문]   Immunohistochemical Study of GLI-1 Expression in the Basal Cell Carcinoma of Sun-Exposed and Non-Exposed Areas  

    Seo, Young Ju , Kim, Chul Woo , Kim, Kwang Ho , Kim, Kwang Joong , Park, Hye Rim , Kim, Yong Sun
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.2 ,pp. 177 - 183 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Basal cell carcinoma (BCC) is the most prevalent cancer in the western world, showing a rapid increase in incidence. Activation of the Sonic hedgehog/Patched (PTCH) and is sisnalling pathway, due to PTCH inactivation, is a key event in sporadic and familial BCC development in humans and is associated with transcriptional activation of specific target genes, including GLI-1. Recently, PTCH inactivation by UV-specific mutation has been reported to develop BCC. OBJECTIVE: To evaluate the expression pattern of GLI-1 oncogene in BCC of sun-exposed and non-exposed areas of skin. METHOD: We examined 20 cases of BCC, and 4 cases of BCC occurring in sun-exposed and non-exposed areas, using an immunohistochemical method with paraffin-embedded sections. RESULTS: The results were as follows. 1. All cases of BCC showed a positive staining for GLI-1 protein. 2. In the staining pattern of GLI-1 protein, BCC in both sun-exposed and non-exposed areas showed diffuse staining throughout the tumor lobules. Moreover, the degree of staining was not found to be different between the BCC of sun-exposed and non-exposed areas. CONCLUSION: These results suggest that increased GLI-1 expression is important for BCC development. And multiple factors, including PTCH mutation due to UV irradiation, may affect GLI-1 expression.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  6. [국내논문]   Clinical Study of the Surgical Excision of Subcutaneous Tissue Combined with the Assistant Subcutaneous Shaver Method for treatment of Axillary Osmidrosis and Hyperhidrosis  

    Kim, Gyoung Moon , Kim, Hee Su , Kim, Si Yong
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.2 ,pp. 184 - 193 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Classical surgical treatment of axillary osmidrosis and hyperhidrosis results in many complications such as scarring, hematoma and necrosis, therefore, gentle skin flap cares is needed. OBJECTIVE: In order to lessen the complications and to obtain an improved clinical outcome, a new easy-learn, surgical excision method of treating subcutaneous tissue is required. METHOD: On 16 patients, We carried out a type-1 surgical method to treat axillary osmidrosis and hyperhidrosis. This invoved major removal of the subcutaneous tissue by scissor excision, and partial removal by the subwtaneous shaver method, to minimise trauma. We then analyzed the clinical efficiency, complications, patient satisfaction, and pathologic specimens according to clinical severity. RESULTS: All 16 patients showed an improved odor or sweating pattern, and a good or very good level of satisfaction. One patient also showed that hematoma was improved with proper post- operative care. Hyperactivity of the apocrine glands in osmidrosis and eccrine gland in hyperhidrosis was seen, and various morphologic features of apoeccrine glands were found in both osmidrosis and hyperhidrosis. We observed that apocrine and eccrine glands were completely excised by following the biopsy of 2 patients. CONCLUSION: Our present method of minimal skin incision and major removal of subcutaneous fat with manual scissor excision, in combination with partial excision with the subcutaneous shaver method, showed a good clinical outcome and few complications.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  7. [국내논문]   Cytotoxicity of Capsaicin on Cultured Human Skin Fibroblast  

    Yun, Seok Kweon , Kim, Jong Keun , Kim, Seong Jin , Won, Young Ho
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.2 ,pp. 193 - 203 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Capsaicin has been shown to have different biologic and toxic effects, depending on non-neuronal cells and several transformed cells, however no study has been reported from cultured human skin fibroblast. OBJECTIVE: Present study was aimed to evaluate the cytotoxicity and its mechanism of capsacin on the cultured human skin fibroblast. MATERIAL AND METHOD: Normal neonatal human fibroblasts were used, and changes of cell survival were measured by MTT assay after the cells were pre-treated with growth factors, receptor antagonist, antioxidants, calcium modulators were pre-treated or co-treated with capsaicin. RESULTS: Suvival of fibroblast was significantly increased by treatment with EGF (10ng/ml), bFGF (10ng/ml), capsazepine (10M) but inhibited by cycloheximide (1g/ml). When 200 M capsaicin was added to fibroblasts, chromatin condensations were observed at 12 hours and cell survival rate was reduced to 25-50% at 24 hours. Vanilloid receptor antagonists, capsazepine and ruthenium red, did not prevent the toxic effect of capsaicin, and 10M capsazepine paradoxically rather enhanced the cytotoxicity. In contrast to bFGF (10ng/ml), EGF (10, 100ng/ml) enhanced the cytotoxicity of capsaicin. Neuropeptides, substance P (1, 10nM) and CGRP (1, 10nM), and a structural analogue to capsaicin, tyrosine (0.3-1.2mM) did not affect the cytotoxicity. However, antioxidants such as trolox (100M) and ascorbic acid (0.1, 0.3 mM) reduced the capsaicin cytotoxicity. Of calcium modulating agents, nifedifine, a Ca2+ channel blocker (10, 20M) and cyclopiazonic acid, a Ca2+-ATPase inhibitor in ER (10M) did not influence the cytotoxicity, however BAPTA/AM (10M) as a chelater for cytoplasmic free calcium ion (10M) significantly decreased capsaicin cytotoxicity. Unlike cycloheximide, z-VAD-FMK, a protein synthesis inhibitor and a non-specific caspase inhibitor, prevented the capsaicin cytotoxicity. The DNA ladder and TUNEL positive cells were observed among the capsaicin treated fibroblasts and Western blot revealed caspase-3 activity. CONCLUSION: The capsaicin-induced cytotoxicity on human skin fibroblasts is likely to suggest the mechanism of an apoptotic pathway, which can possibly be prevented by antioxidants.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  8. [국내논문]   배양 섬유모세포에 대한 capsaicin의 세포독성  

    윤석권 , 김종근 , 김성진 , 원영호
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.2 ,pp. 194 - 203 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Capsaicin has been shown to have different biologic and toxic effects, depending on non-neuronal cells and several transformed cells, however no study has been reported from cultured human skin fibroblast. OBJECTIVE: Present study was aimed to evaluate the cytotoxicity and its mechanism of capsacin on the cultured human skin fibroblast. MATERIAL AND METHOD: Normal neonatal human fibroblasts were used, and changes of cell survival were measured by MTT assay after the cells were pre-treated with growth factors, receptor antagonist, antioxidants, calcium modulators were pre-treated or co-treated with capsaicin. RESULTS: Suvival of fibroblast was significantly increased by treatment with EGF (10ng/ml), bFGF (10ng/ml), capsazepine (10M) but inhibited by cycloheximide (1g/ml). When 200 M capsaicin was added to fibroblasts, chromatin condensations were observed at 12 hours and cell survival rate was reduced to 25-50% at 24 hours. Vanilloid receptor antagonists, capsazepine and ruthenium red, did not prevent the toxic effect of capsaicin, and 10M capsazepine paradoxically rather enhanced the cytotoxicity. In contrast to bFGF (10ng/ml), EGF (10, 100ng/ml) enhanced the cytotoxicity of capsaicin. Neuropeptides, substance P (1, 10nM) and CGRP (1, 10nM), and a structural analogue to capsaicin, tyrosine (0.3-1.2mM) did not affect the cytotoxicity. However, antioxidants such as trolox (100M) and ascorbic acid (0.1, 0.3 mM) reduced the capsaicin cytotoxicity. Of calcium modulating agents, nifedifine, a Ca2+ channel blocker (10, 20M) and cyclopiazonic acid, a Ca2+-ATPase inhibitor in ER (10M) did not influence the cytotoxicity, however BAPTA/AM (10M) as a chelater for cytoplasmic free calcium ion (10M) significantly decreased capsaicin cytotoxicity. Unlike cycloheximide, z-VAD-FMK, a protein synthesis inhibitor and a non-specific caspase inhibitor, prevented the capsaicin cytotoxicity. The DNA ladder and TUNEL positive cells were observed among the capsaicin treated fibroblasts and Western blot revealed caspase-3 activity. CONCLUSION: The capsaicin-induced cytotoxicity on human skin fibroblasts is likely to suggest the mechanism of an apoptotic pathway, which can possibly be prevented by antioxidants.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  9. [국내논문]   A Clinical Analysis of Surgical Treatment for Axillary Osmidrosis by the Bipedicle Flap Method and CO2 Laser  

    Lee, Jae Bong , Oh, Chang Keun , Chin, Hyun Woo , Kim, Moon Bum , Jang, Ho Sun , Kwon, Kyung Sool
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.2 ,pp. 204 - 210 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Axillary osmidrosis is caused by excessive secretion of apocrine sweat, which causes foul odor and extreme social embarrassment. Axillary osmidrosis can be treated by a number of methods, but surgery is the treatment of choice. OBJECTIVE: The purpose of this study was to evaluate clinical results of surgical treatment for axillary osmidrosis by the bipedicle flap method and CO2 laser. METHODS: December 1995 and December 2002, 53 patients with axillary osmidrosis were treated by the bipedicle flap method and with CO2 laser. Post-operative complications and convalescent time in the patients (106 axillae) were then of evaluated. Among them, 37 patients were followed up for a minimum 6 months, and the patients were asked to complete a questionnaire on their family history, aggravation factors, association with wet ear wax or palmoplantar hyperhidrosis, degree of satisfaction, decreased sweating, decreased axillary hair, tension on motion, and scarring. RESULTS: Follow-up ranged from 6 to 84 months (mean: 41months). Thirty one (83.8%) out of 37 patients were satisfied or partially satisfied with the results. Six (16.2%) out of 37 patients were dissatisfied. Post-operative complications were seen in 27 (25.5%) out of 106 axillae. The average convalescent time was 18 days. CONCLUSION: Based on the long-term evaluation, this bipedicle flap method and CO2 laser treatment were found to be effective for axillary osmidrosis.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  10. [국내논문]   Clinicopathological Study of Actinic Keratoses in Korea  

    Kim, You Jeong , Kim, Si Yong , Kim, Gyoung Moon
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.2 ,pp. 211 - 217 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Actinic keratosis is one of the most common precancerous lesions, and its incidence in Western society has been reported to be up to 40%. However, few clinical and histopathologcial studies of actinic keratosis have been conducted in Korea. OBJECTIVE: The purpose of this study was to investigate clinical and histopathological features of actinic keratosis in Koreans. METHODS: We reviewed the medical records and biopsy specimens of 63 cases previously diagnosed as actinic keratosis at St.Vincents hospital of Catholic Medical Center from January 1999 to June 2003. RESULTS: We were able to compile clinical data and histologic information on 63 cases of actinic keratosis 1. The mean age at diagnosis was 72.6 years, and all the patients were over 50 years old. Actinic kerotosis developed predominantly in females at the sex ratio of 1: 3.8. 2. The disease duration was more than 1 year in 69.8% of patients, and there were few associated cutaneous malignancies, except two basal cell carcinoma. 3. Half of the patients was asymptomatic, however, 34.9% and 15.9% of the patients complained of pruritus and pain, respectively. The lesions were usually solitary, less than 1cm, and erythematous. 4. Actinic keratosis was involved mostly in face, especially cheek, forehead, chin, and nose by decreasing order. 5. Histopathologically, hypertrophic type was noted in 30.2% of the cases, atrophic type in 44.4%, bowenoid type in 19.0%, acantholytic type in 3.2%, and pigmented type in 3.2%. The histopathological scores according to subtype were 5.00(1.76) in hypertrophic type, 3.54(1.82) in atrophic type, and 6.83(1.03) in Bowenoid type. 6. The most common treatment modality was cryotherapy with liquid nitrogen, and surgical resection, electrodessication, and CO2 Laser were also used for the treatment of actinic keratosis. The recurrence was observed in one patient treated by cryotherapy and two patients by electodessication. CONCLUSION: Actinic keratosis in Koreans was precancerous lesion usually present on the face of female patients over 50 years old. Various histopathologic types including hypertrophic, atrophic, Bowenoid, acantholytic and pigmented type were noted, and the most common type was atrophic type. Actinic keratosis could be treated by cryotherapy with liquid nitrogen, surgical resection, eletrodessication and CO2 laser. However, because of the possibility of recurrence, close follow-up is needed.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지

논문관련 이미지