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저널/프로시딩 상세정보

권호별목차 / 소장처보기

H : 소장처정보

T : 목차정보

大韓皮膚科學會誌 = Korean journal of dermatology 30건

  1. [국내논문]   The Effect of an AP-1 decoy on Collagen Synthesis in Wound Healing on Rat Skin: The use of Gene Therapy to Minimise Scarring  

    Park, Soo Jung , Lee, Kyu Suk
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.4 ,pp. 435 - 441 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: The wound healing process is composed of inflammation, cellular growth, migration, angiogenesis and an extracellular matrix composition. In this process, fibroblasts proliferate but leave scarring due to their excessive growth. The process is controlled by platelet derived growth factor (PDGF) and basic fibroblast growth factor (bFGF), while PDGF and transforming growth factor beta(TGF-beta) play a major role in controlling extracellular matrix composition. Numerous modalities have been tried to treat this abnormal response, but the results were unsatisfactory. TGF-beta is activated by AP-1 (Activator protein). Theregone, AP-1 decoy oligodeoxynucleotides(ODN) had recently been used for regulation of TGF-beta transcription as a gene treatment. OBJECTIVE: The purpose of this study was to examine the effect of blocking TGF-beta transcription by an AP-1 decoy ODN on collagen synthesis in wound healing on rat skin. METHODS: In this study, the effect of AP-1 decoy ODN on collagen synthesis was examined by Hematoxylin and eosin (H&E) staining, Masson's trichrome staining, and immunohistochemical staining for TGF-beta on damaged rat skin. RESULTS: In the H&E stain and Masson's trichrome stain of the damaged rat skin, the number of collagen fibers of AP-1 decoy ODN treated group had decreased in compared to the control group, especially on the 15th day after incision. With immunohistochemical stain, the expression of TGF-beta in fibroblasts, inflammatory cells and the endothelium of vessel walls in the dermis had also decreased, compared to the control group. TGF-beta was expressed in the dermis from the 3rd day, and predominantly in the fibroblasts on the 15th day after incision. CONCLUSION: These results indicate that AP-1 decoy ODN is a powerful down-regulator of collagen synthesis in wound healing through significant suppression of TGF-beta expression in damaged skin. Therefore, AP-1 decoy ODN can be used effectively to treat or minimize scarring on damaged skin.

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  2. [국내논문]   A Comparison of Minimal Erythema Dose and Minimal Melanogenic Dose Induced by Ultraviolet A-1, Broad Band Ultraviolet A, Narrow Band Ultraviolet B, and Broad Band Ultraviolet B  

    Jeon, Young Seung , Suh, Kee Suck , Kim, Sang Tae
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.4 ,pp. 442 - 449 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: The erythemal and tanning responses of the skin to UV radiations, which are used as diagnostic phototest and guideline of phototherapy, are different, depending on the races and light sources. Minimal erythema dose (MED), barely perceptible minimal melanogenic dose (MMDb) and well-defined border minimal melanogenic dose (minimal melanogenic dose, MMDw) of broad band UVA (BBUVA), UVA-1, broad band UVB (BBUVB), and narrow band UVB (NBUVB) have not yet been reported. Therefore this study was undertaken to measure the MED, MMDb and MMDw of BBUVA, UVA-1, BBUVB and NBUVB radiation. METHODS: Ten healthy Korean volunteers were recruited. Four volnuteers were Fizpatrick skin type III and six were IV. In this study, a metal halide lamp (SUPUVASUN 3000) was used as the BBUVA and UVA-1 light sources, a fluorescent blacklight lamp (Philips TL 20W/12 UVB lamp) as the BBUVB, and a fluorescent blacklight lamp (Philips TL 20W/01) as the NBUVB. The MED, MMDb and MMDw of the skin were visually assessed 24 hours and 7 days after irradiation. RESULTS: 1. BBUVA MED, MMDb and MMDw of BBUVA were 53.0+/-8.2J/cm2 (mean+/-S.D.), 38.0+/-7.8J/cm2, and 51.0+/-8.7J/cm2, respectively. MED, MMDb and MMDw of BBUVA in Fitzpatrick skin phototype III (FST III) were 50.0+/-8.1J/cm2, 35.0+/-5.7J/cm2, and 47.5+/-5.0J/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST IV were 55.0+/-8.3J/cm2, 40.0+/-8.9J/cm2, and 53.3+/-10.3J/cm2, respectively. 2. UVA-1 MED, MMDb and MMDw of BBUVA were 58.0+/-9.1J/cm2, 40.0+/-4.7J/cm2, and 54.0+/-9.6J/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST III were 52.5+/-9.5J/cm2, 37.5+/-5.0J/cm2, and 52.5+/-12.5J/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST IV were 61.6+/-7.5J/cm2, 41.6+/-4.0J/cm2, and 55.0+/-8.3J/cm2, respectively. 3. BBUVB MED, MMDb and MMDw of BBUVA were 52.0+/-12.2mJ/cm2, 57.0+/-10.5mJ/cm2, and 69.0+/-11.0mJ/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST III were 42.5+/-5.0mJ/cm2, 55.0+/-5.7mJ/cm2, and 67.5+/-9.5mJ/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST IV were 58.3+/-11.6mJ/cm2, 58.3+/-13.2mJ/cm2, and 70.0+/-12.6mJ/cm2, respectively. 4. NBUVB MED, MMDb and MMDw of BBUVA were 680+/-131.6mJ/cm2, 770+/-105.9mJ/cm2, and 910+/-99.4mJ/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST III were 650+/-129.1mJ/cm2, 725+/-125.8mJ/cm2, and 850+/-100.0mJ/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST IV were 700+/-141.4mJ/cm2, 800+/-89.4mJ/cm2, and 950+/-83.6mJ/cm2, respectively. CONCLUSION: The MMDb and MMDw induced by BBUVA and UVA-1 were less than MED induced by BBUVA and UVA-1, but MED induced by BBUVB and NBUVB was less than MMDb and MMDw induced by BBUVB and NBUVB. These results suggest that the erythemal and tanning response of the skin to UV radiations are different, depending on the UV wave length.

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  3. [국내논문]   Skin Organ Culture Model for Evaluation of Melanin Pigmentation  

    Lee, Joong Sun , Lee, Ji Yeoun , Choi, You Mi , Jung, Yong Sik , Kang, Won Hyoung , Kang, Hee Young
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.4 ,pp. 450 - 454 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Skin organ culture is widely used as a tool to investigate skin biology or skin disease. OBJECTIVE: The objective of the present study was to develop an ideal skin organ culture model for evaluation of melanin pigmentation. METHODS: An air-liquid interface and submerged method were used. The histology of the cultured skin was studied with H&E stain. To examine the epidermal pigmentation, Fontana-Masson stain and NKI/beteb stain were performed. Pigment modifiers (arbutin, LY294002) were applied to the culture medium for 3 days as an air-liquid interface culture. RESULTS: The general architecture of the skin was well maintained for 5 days. The melanin pigment decreased during culture without change of the number of melanocytes. As expected from previous reports, the effect of pigment modifiers (arbutin, LY294002) on cultured skin was demonstrated. CONCLUSION: The results indicate that this skin organ culture model is useful in evaluating the melanin pigmentation

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  4. [국내논문]   The Effect of Autologous Epidermal Grafting in the Treatment of Intractable Vitiligo  

    Cho, Wan Ik , Kim, Ji Eun , Seo, Seong Jun , Hong, Chang Kwun
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.4 ,pp. 455 - 461 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: There are many therapeutic methods for treating vitiligo including PUVA, narrow-band UVB, topical corticosteroids, tacrolimus, calcipotriol, intralesional injection of steroids or oral corticosteroids, but there is no reliable treatment. Autologous epidermal grafting has been used by several authors, and is reported to be a surgical method which has minimal adverse effect, little risk of scarring, and is easily performed in the clinic. OBJECTIVE: The purpose of this study was to evaluate the effectiveness of autologous epidermal grafting in the treatment of vitiligo, and investigate both patient satisfaction, and any adverse effects. METHODS: The evaluation was conducted using 44 patients (48 cases) with intractable vitiligo who had been treated by autologous epidermal grafting using suction blistered epidermis. We investigated both patient satisfaction, and any problems or adverse effects during the procedure. The efficacy was rated as excellent (repigmentation >75%), good (repigmentation 75-50%), fair (repigmentation 50-25%), or poor (repigmentation

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  5. [국내논문]   Virus Types and Clinical Patterns in Genital Herpes  

    Kang, Joo Hyung , Ro, Young Suck
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.4 ,pp. 462 - 468 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Genital herpes is a sexually transmitted disease, which affects millions of people worldwide, and is caused by the herpes simplex virus (HSV). Recent data has shown that in a large proportion of genital herpes, there has been a shift from HSV type 2 (HSV-2) to to HSV type 1 (HS V-1) being the main cause. OBJECTIVE: Our objective was to study the types of virus and clinical patterns of patients with genital herpes in Korea METHODS: We investigated the clinical patterns and virus types of 13 patients with genital herpes using indirect immunofluorescence (IIF) after viral culture, and/or nested-multiplex polymerase chain reaction (NM-PCR). RESULTS: Of the 13 patients, HSV-1 was isolated in 2 patients (15.4%), HSV-2 in 7 patients (53.8%), and mixed infection with both HSV-1 and HSV-2 in 4 patients (30.8%). Recurrence of lesions was found to occur when the patient had HSV-2 or a mixed infection, but not the HSV-1 infection. Of 5 patients who underwent IIF and NM-PCR simultaneously, the virus was detected by NM-PCR only, not by IIF after viral culture, in 2 of the patients. CONCLUSION: HSV-1 infection as a cause of genital herpes is increasing, but recurrence is more common in HSV-2 infection. This study demonstrates that HSV-1 and HSV-2 can be detected simutaneously in the same anatomic region of genital herpes, and that NM-PCR is a more sensitive method for the detection and typing of HSV than IIF after viral culture.

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  6. [국내논문]   Topical Photodynamic Therapy for Treatment of Actinic Keratosis Using Light-Emitting Diode (LED) Device  

    Lee, Joong Sun , Kim, Yoon Jun , Kang, Hee Young , Lee, Eun So , Oh, Choong Hun , Kim, You Chan
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.4 ,pp. 469 - 474 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Photodynamic therapy is a treatment modality which involves the sequential administration of a photosensitizer and light. Topical photodynamic therapy is being increasingly used for superficial non-melanoma skin cancers and their precursors. OBJECTIVE: The purpose of this study was to evaluate the effectiveness and side effects of treating actinic keratosis with photodynamic therapy using a light-emitting diode device and 20% 5-aminolevulinic acid. METHODS: Photodynamic therapy, with a 630+/-50nm light-emitting diode device and 5-aminolevulinic acid, was used to treat 12 lesions of actinic keratosis on 8 patients. The light intensity used was 50mW/cm2 , and the light dose was 100-120J/cm2 . Four weeks after 1 or 2 treatment sessions, the outcome was evaluated by histopathological findings. RESULTS: Complete clearance was achieved in 8 of 12 lesions after a single treatment, and in 3 of 12 lesions after 2 treatment sessions. Only 1 case showed partial response after 2 treatment sessions. Only 2 patients suffered from a stinging sensation when exposed to the light therapy. CONCLUSION: Topical photodynamic therapy using a light-emitting diode is safe and effective in the treatment of actinic keratosis.

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  7. [국내논문]   Treatment of Verruca Plana with High Dose Cimetidine Therapy  

    Park, Chang Ook , Chung, Kee Yang , Chung, Woo Gil
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.4 ,pp. 475 - 479 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: It is often a difficult problem for dermatologists to treat verruca plana. Cimetidine is a H2 histamine receptor antagonist that has been used mainly to treat peptic ulcer disease. The successful use of cimetidine in the treatment of viral warts has been reported previously using doses of 40mg/kg/day and has the advantage of being painless and easy to administer. OBJECTIVE: The purpose of this study was to evaluate the clinical effects of high dose cimetidine therapy for verruca plana. METHODS: Thirty-six patients with verruca plana were treated with high dose cimetidine therapy (22 females, 14 males; age range 7-56 years). RESULTS: Of the 36 patients who completed the study, 15 patients (41.7%) showed complete remission. 8 patients (22.2%) showed partial remission. There was no significant differences among the complete remission, the partial remission and the no response groups. There were a few adverse effects including transient liver enzyme elevation and gynecomastia which were normalized after the cimetidine was discontinued. CONCLUSION: High dose cimetidine therapy is an effective treatment modality for verruca plana without severe adverse effects.

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  8. [국내논문]   A Clinical Study of Dermatoses of Korean Vietnam Veterans Exposed to Agent Orange  

    Rho, Jin Hyuk , Joh, Ok Ja , Park, See Ryong , Haw, Choong Rim , Han, Jee Yoon
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.4 ,pp. 480 - 488 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Scientific and epidemiologic studies have shown that several dermatoses of Vietnam veterans were caused by Agent Orange. Most of the previous studies on Vietnam veterans have been about the relationship between systemic diseases including limited dermatoses and Agent Orange, but there have been no clinical studies of dermatoses of Korean Vietnam veterans exposed to Agent Orange. OBJECTIVE: We conducted this study to find out the distribution and characteristics of dermatoses of Korean Vietnam veterans exposed to Agent Orange. METHODS: A total of 19, 262 Korean Vietnam veterans who received their first dermatological examination at Seoul Veterans Hospital between January 1997 and December 2003 were included in this study, which consisted of a skin examination and 15-item questionnaire. RESULTS: 1. The distribution of dermatoses groups were as follows: pruritus, psychocutaneous disorders, and neurocutaneous dermatoses (36.1%), dermatomycosis and deep mycosis (20.5%), eczema (11.6%), diseases of the skin appendages (3.6%), epidermal and adnexal nevi and tumors (2.1%), drug eruption, erythema, and urticaria (1.8%), and papulosquamous diseases (1.5%). 2. Pruritus (31.6%) was the most frequent dermatosis in all age groups. 3. The frequency of dermatoses related to exposure to Agent Orange were as follows: seborrheic dermatitis (4.8%), chronic urticaria (1.7%), psoriasis vulgaris (1.2%), xerotic eczema (0.5%), photosensitive dermatitis (0.2%), chloracne (0.1%), soft tissue sarcoma (0.1%), and malignant tumors (0.01%). 4. With regard to regional groups of dispatch in Vietnam, QuiNhon (20.1%) was the most frequent area of dispatch. There was no statistically significant difference in frequency of dermatoses related to exposure to Agent Orange between Dian, where larger amounts of Agent Orange were sprayed, and the other regional groups. 5. For duration of dispatch in Vietnam, there was no statistically significant difference in frequency of dermatoses related to exposure to Agent Orange between two groups of duration. CONCLUSION: This study showed the distribution and characteristics of dermatoses of Korean Vietnam veterans exposed to Agent Orange, and may be helpful as the fundamental epidemiologic data of dermatoses of Korean Vietnam veterans for dermatologists to examine.

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  9. [국내논문]   A Comparison of Expressions of MMP-3, MMP-7, TIMP-1 and Apoptosis in Keratoacanthoma and Squamous Cell Carcinoma  

    Kim, So Young , Kim, Seong Hyun , Choi, You Won , Myung, Ki Bum
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.4 ,pp. 489 - 495 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Keratoacanthoma (KA) is a unique neoplasm, usually accompanied by rapid growth and regression, and the histologic findings resemble those of squamous cell carcinoma (SCC). Histologic differentiation of KA and SCC is challenging, therefore a number of studies have been carried out to differentiate these two entities using immunohistochemical staining. However, the results were inconsistent. There is now a debate as to whether KA is a benign tumor or a less aggressive variant of SCC. OBJECTIVE: The purpose of this study was to examine the expression patterns of MMP-3, MMP-7, TIMP-1, the apoptotic index in KA and SCC, and the usefulness of immunohistochemical staining in differentiating these two entities. METHODS: Formalin-fixed, paraffin-embedded biopsy specimens obtained from 12 KA and 16 SCC patients were investigated for the expressions of MMP-3, MMP-7 and TIMP-1 using an immnohistochemical staining method and apoptotic index by TUNEL method. RESULTS: 1. The expression of MMP-3 in mass was slightly higher in the SCC group (3.4+/-1.03) than the KA group (2.7+/-1.50). The expression of MMP-3 on the stroma was significantly higher for the SCC group (2.6+/-0.96) than the KA group (1.5+/-1.24) (p

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  10. [국내논문]   A Case of Propylthiouracil-induced Lupus Erythematosus Accompanied by Antineutrophil Cytoplasmic Antibody-positive Vasculitis  

    Kim, Jae Wang , Kim, Jin Seok
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.4 ,pp. 496 - 500 , 2005 , 0494-4739 ,

    초록

    Propylthiouracil (PTU) as a drug for hyperthyroidism is known to be associated with drug-induced lupus erythematosus (LE) and antineutrophil cytoplasmic antibody (ANCA)-positive vascultis. A 29-year-old woman who had been receiving PTU for 12 months developed spiking fever, arthralgia and multiple purpuric skin lesions. Perinuclear ANCA (p-ANCA) with antimyeloperoxidase activity, antinuclear antibody and antihistone antibody were positive. Her condition improved after the withdrawal of PTU. The pertinent evaluation for this case established PTU-induced LE accompanied by ANCA-positive vasculitis. Although PTU-induced LE or ANCA-positive hypersensitivity vasculitis by PTU have been frequently reported in the literature, it is extremely rare that these two diseases have occurred simultaneously due to PTU, as in this case.

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