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저널/프로시딩 상세정보

권호별목차 / 소장처보기

H : 소장처정보

T : 목차정보

大韓皮膚科學會誌 = Korean journal of dermatology 30건

  1. [국내논문]   Clinical Observation of 69 Cases of Trichotillomania  

    Lee, Yong Ju , Ihm, Chull Wan
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.5 ,pp. 567 - 575 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Trichotillomania is a self-induced, primary psychiatric disorder. Dermatologists, however, should understand the nature of the disorder, because it is a type of alopecia which is more likely to be examined first by dermatologists, and early treatment yields a better prognosis. A long-term observation of the clinical course of trichotillomania patients is lacking in Korean dermatological literature. OBJECTIVE: We attempted to appreciate the long-term clinical course, the sociofamilial situation and other associated disorders, as well as the trichological findings of the disease. METHOD: Sixty nine trichotillomania patients, diagnosed from May 1983 to July 2003, were reviewed via medical records, out-patient clinic follow-up and by telephone survey. RESULTS: 1. The average age of onset of the lesion was 10.1 years old, and the average age of the first examination was at 11.1 years. 89.1% of the patients were found to be adolescent or younger. Sex prevalence showed female predominance in adulthood, similar distributions in adolescence and late childhood, but more males in early childhood. 2. The duration between onset of the lesion and first examination were several months in early childhood, one to two years in adolescence and four to eight years in adults. 3. The sites most frequently affected were the parietal (78.3%) and the frontal scalp (50.7%). Thirty eight patients (55.1%) showed a single lesion, and 18 patients (26.1%) showed severe involvement with more than 25% of the scalp affected. 4. The broken shafts of terminal anagen hairs were seen in most patients (89.9%). Fifty nine patients (85.5%) had hair thinning patches composed of varied hairs such as broken shafts, new emerging tapered hairs, vellus and intermediate hairs, comedone-like black dots and empty follicles. In the remaining 10 patients (14.5%), one type of the pre-mentioned hair states was dominantly seen. 5. In late childhood and older cases, about 1/3 of the patients admitted to repetitive hair touching, and family members confirmed this behavior in 2/3 of the cases. 6. Of the patients evaluated in the study, only 13% had suffered a stressful situation, 13% a broken home or 6% from maladjustment. The rate of dual income families among the patients was 44%, similar to the rate within the general population of Korea. 7. Forty seven patients were assessed for an average of 6 years and 7 months. Thirty two patients (68.1%) were diagnosed as free from trichotillomania, and 15 patients (31.9%) showed continuing lesions. By age distinction, the persistence rates were 75% in adult patients, 29% in late childhood and adolescent patients, and 22% in early childhood patients. By gender difference, 78.3% (18/23) of males and 58.3% (14/24) of females were free from alopecia. CONCLUSION: Dermatological findings, patients cognition of their behavior, and clinical analysis of 69 cases of trichotillomania were made with the results of 6 years and 7 months of follow-up observations. The clinical analysis included not only dermatological findings, but also patients' cognition and other factors which might influence the patients' habitual behavior.

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  2. [국내논문]   The Study of Wound Healing Using Cultured Autologous Dermal Fibroblast of Guinea Pig  

    Kim, Gyoung Moon , Lee, Woo Sun , Hwang, Seung Jun , Kye, Young Chul , Kim, Heong Ok , Kim, Si Yong
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.5 ,pp. 576 - 586 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Autologous cultured dermal fibroblasts can be transplanted to the full thickness of skin wounds and this successfully accelerates the early wound healing of epidermis and dermis with less inflammation and scarring than allogeneic transplantations. The wound-healing effect of dermal fibroblasts is thought to be due to their growth factor and extracellular matrix releasing effects. Fibroblasts could therefore help chronic wound healing, where lower concentration of growth factors have been observed. OBJECTIVE: The purpose of this study was to examine the early wound healing effects of the autologous cultured dermal fibroblasts and to confirm that several growth factors and fibroblasts are closely associated in the mechanism of wound healing. METHODS: Suspensions of cultured autologous dermal fibroblasts were transplanted to full thickness wounds in 15 guinea pigs, and the wounds were then covered with transparent membrane. Wound biopsy materials were excised and collected from 9 guinea pigs at 7, 14, 21 and 28 days after wounding. Comparisons of the clinical wound healings between the experimental and control groups at the 3rd, 7th and 14th day after fibroblast transplantations were made in 8 guinea pigs, in which continuous clinical observation was possible in the same guinea pigs. Samples were processed for routine hematoxylin and eosin stains, immunohistochemical stains for fibroblast growth factor (FGF), transforming growth factor beta (TGF-beta), vascular endothelial growth factors (VEGF), and insulin like growth factors (IGF). RESULTS: The experimental groups showed decreased wound surface area at 3 and 7 days after transplantations, and more vascular, granulomatous wounds and fibroplasia responses compared with the control groups. Immunohistochemal stains revealed increased positive staining for FGF, TGF beta, and VEGF at the 1st, 2nd and 3rd weeks, compared with the controls. CONCLUSION: Transplantations of autologous cultured dermal fibroblasts proved to be clinically effective in the early wound healing of full thickness wounds of guinea pigs, and growth factors such as FGF, TGF VEGF must have some role in the mechanism of wound healing by autologous dermal fibroblasts.

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  3. [국내논문]   opical Photodynamic Therapy of Verruca Using a Light-Emitting Diode Device  

    Rhee, Seung Ho , Kang, Hee Young , Lee, Eun So , Oh, Choong Hun , Kim, You Chan
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.5 ,pp. 587 - 592 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Photodynamic therapy (PDT) has been reported to be useful in treating nonmelanoma skin cancers and a variety of benign skin conditions including warts. However, only one case of condyloma acuminata treated with PDT has been reported in Korea. OBJECTIVE: The purpose of this study was to evaluate the complete response rate and side effect of PDT, using light emitting diode (LED) device and 20% 5-aminolevulinic acid (ALA) to treat recalcitrant verruca. METHODS: We treated 8 cases of recalcitrant verruca (3 cases of verruca vulgaris, 3 cases of verruca plana, 2 cases of condyloma acuminata) with PDT, using ALA and a 630+/-50nm LED device. The light intensity was 30-50mW/cm2 and the light dose was 50-120J/cm2. RESULTS: After treatment, two cases of verruca plana showed complete response, and one case of verruca plana, two cases of verruca vulgaris, and two cases of condyloma acuminata showed partial response. However, one case of verruca vulgaris showed no response. There was only burning sensation and/or wheals during treatments. CONCLUSION: Topical PDT may be an alternative therapy in the treatment of verruca, especially of verruca plana.

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  4. [국내논문]   A Study of Nickel Content in Korean Foods  

    Han, Hee Jin , Lee, Bo Hyun , Park, Chun Wook , Lee, Cheol Heon , Kang, Yun Seo
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.5 ,pp. 593 - 598 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Nickel-sensitive patients may suffer from persistent dermatitis even if they avoid cutaneous contact with nickel-plated items. Therefore, an endogenous cause of nickel-induced dermatitis has been suggested. In Western countries, many studies suggested that reduction of dietary intake of nickel might benefit nickel-sensitive patients. OBJECT: We measured the nickel content of Korean foods, since a nickel-restricted diet is essential for nickel-sensitive patients. METHOD: We ground the food, then nitric acid, sulphuric acid, and fluoric acid were added to the ground foods to dissolve organic matter. We then measured nickel content in these samples using Inductive Coupled Plasma-Mass Spectrometry. RESULTS: A green tea bag contained 235.57mg Ni/kg, a black tea bag 62.79mg Ni/kg, chocolate 27.87mg Ni/kg, crisps 12.70mg Ni/kg, wheat flour 12.15mg Ni/kg, Welsh onion 0.026mg Ni/kg, garlic 0.016mg Ni/kg, milk 0.004 mg Ni/kg, egg 0.002mg Ni/kg, and salt 0.0mg Ni/kg. CONCLUSION: High nickel concentrations were found in green tea bag, chocolate, crisps, wheat flour, coffee bean, peanuts, and kimchi etc. On the other hand, rice, barley and spice had low content of nickel. Formulation of nickel-restricted diet using these results is expected to be helpful in the treatment of nickel-sensitive patients.

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  5. [국내논문]   Study of the Patch Tests Results in Patients with Contact Dermatitis due to Cosmetics  

    Lee, Jung Hoon , Park, Hyun Jeong , Lee, Jun Young , Kim, Hyung Ok , Cho, Baik Kee , Kim, Chung Won
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.5 ,pp. 599 - 605 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: With the growing use of cosmetics such as skin care products, toiletries, makeup products, fragrance on an expanding population, reports of unwanted side effects following application of these products is increasing. Allergic contact dermatitis commonly occurs with the use of cosmetics. However, treatment is extremely difficult without knowing the exact causative agent. Therefore, it is important to detect and clarify such agents in order to treat and ultimately prevent allergic contact dermatitis. OBJECTIVE: We attempted to find the popular causative factors of allergic contact dermatitis, especially within cosmetics, and compare the findings with previous Korean and international reports involving allergic contact dermatitis. METHODS: Patch test results of 332 patients suspected of having allergic contact dermatitis related to cosmetics were reviewed. The patients visited 3 hospitals in the Catholic medical center in Korea between 2000 and 2003. The patch tests adopted were of the standard series, cosmetic series, and test samples made from the patient's own cosmetics. RESULTS: The results of this study are summarized as follows; 1. Among allergens of the standard series, nickel sulfate induced the highest positive patch test results (30.5%) within the 321 patients who were tested followed by potassium dichromate, thimerosal and cobalt chloride. 2. Thimerosal showed the highest positive patch test rate (9.2%), followed by octyl gallate and t-butylhydroquinone in a cosmetic series patch test study with 109 patient. 3. A trial patch test with cosmetics from our own patients was made. Among the type of cosmetics to induce a positive patch test, skin care products constituted 47.8%, marking the highest proportion. However, toiletries were the most potent in inducing a positive test result. 4. Correlated to the patch test results from previous Korean and international studies, skin care products most commonly caused allergic contact dermatitis as in our study. However, personal cleanliness products were more common in causing allergic contact dermatitis in our study than in previous Korean and international studies. CONCLUSION: Although skin care products are most prevalent in causing allergic contact dermatitis, the prevalence of allergic contact dermatitis due to toiletries is increasing. This was a clear contrast to the result of previous Korean and international studies. The possibility of allergic contact dermatitis due to toiletries should not be overlooked.

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  6. [국내논문]   A Statistical Study of Dermatoses in the Jeonbuk Province (1979-1980, 1987-2002)  

    Choi, Hyoun Sung , Yun, Seok Kweon , Kim, Han Uk , Ihm, Chull Wan
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.5 ,pp. 606 - 618 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Occurrence of dermatoses are influenced by various environmental factors in the area people live. Jeonbuk province, as well as other parts of Korea, has developed industrially for the past three decades. Until now, no statistical survey on dermatoses in Jeonbuk province has been made. OBJECTIVE: To compare the prevalence and trend of dermatoses by patients' age and time in Jeonbuk province over last 30 years. METHODS: The survey was conducted via the medical records of 55, 335 patients seen in Chonbuk National University Hospital from 1979 to 2002. RESULTS: The study results are summarized as follows: 1. Among the 55, 335 new patients (male 47.2%, female 52.8%), the 15 most common dermatoses were as follows (in order of frequency): dermatophytosis (7.8%), urticaria (7.7%), acne (5.2%), atopic dermatitis (4.9%), alopecia (4.4%), seborrheic dermatitis (4.3%), herpes zoster (4.0%), other eczema (3.9%), vitiligo (3.8%), psoriasis (2.6%), pruritus (2.5%), benign epidermal tumor (2.4%), verruca (2.2%), allergic contact dermatitis (1.7%), and irritant contact dermatitis (1.5%). These comprise 58.9% of the total outpatients. 2. The incidences of atopic dermatitis, alopecia, vitiligo and benign epidermal tumor had increase d (about 5 times), while dermatophytosis and urticaria had decreased (about 0.64 times) during the period. 3. The most frequent dermatoses during the summer season were dermatophytosis and vitiligo. In winter season, they were acne, atopic dermatitis, seborrheic dermatitis, psoriasis, pruritus, benign epidermal tumor and verruca. 4. The occurrence of scabies decreased rapidly from the early 90's and remained at a decreased level. Leprosy and tuberculosis had often occurred during the 80's and then became rare from the 90's. 5. The distribution of patients' age was as follows: The 3rd decade (22.0%), 2nd decade (15.8%), 1st decade (15.5%), 4th decade (14.7%), 5th decade (12.0%), 6th decade (10.3%), 7th decade (2.6%), 8th and above (0.4%). 6. Atopic dermatitis was found to be the most frequent dermatosis in the 1st decade. Vitiligo, benign epidermal tumor, and verruca were the most frequent in the 2nd decade, and urticaria, acne, alopecia, seborrheic dermatitis, psoriasis, allergic contact dermatitis and irritant contact dermatitis in the 3rd decade. Herpes zoster and pruritus were the most frequent in the 6th and 7th decade. CONCLUSION: From medical records between 1979 and 2002, we surveyed kinds, prevalence rates and trends of dermatoses in the Jeonbuk Province. During this period we observed changes in the incidence of the dermatoses with years and seasons. We also found that prevalence rates of the dermatoses were influenced by the time, environment and living conditions of the patients. To the best of our knowledge, this is the first survey on the occurrence of dermatoses Jeonbuk Province of Korea.

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  7. [국내논문]   The Effect of Ultrasound on Epidermal Permeability Barrier and Lipid Synthesis  

    Cho, Nam Joon , Kyoo, Jung Se , Jun, Jung Eun , Choi, Ki Joo , Park, Suk Jong , An, Ho Jung , Ahn, Sung Koo , Lee, Seung Hun
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.5 ,pp. 619 - 629 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Abrogation of the epidermal permeability barrier results in an increased lipid synthesis and lipid synthetic enzymes. Recent studies have shown that ultrasound can induce changes in the epidermal calcium gradient that increase lamellar body secretion without increasing transepidermal water loss (TEWL). OBJECTIVE: We undertook this study to identify whether ultrasound can stimulate lipids synthetic enzymes and lipids synthesis. METHODS: Ultrasounds were applied to the skin of hairless mice, and we then quantified lipid synthesis, real time RT-PCR to measure mRNA activities of lipid synthetic enzymes and TEWL. We also performed RuO4 post fixation and calcium ion capture cytochemistry. RESULTS: There were no significant changes of TEWL before and after ultrasound treatment. Calcium in upper epidermis decreased and that in lower epidermis increased after treatment of ultrasound and some recovery of epidermal calcium gradient after 6 hours. In RuO4 post fixation, lacuna dilatation, partial distension of intercorneocyte space, loss of multilamellar structures and increased lamellar body secretion were observed in the epidermis of the ultrasound treated hairless mice. The mRNA levels of 3-hydroxy 3-methylglutaryl coenzyme A (HMG CoA) reductase, serine palmitoyl transferase (SPT), fatty acid synthase (FAS) and lipid synthesis were increased in the epidermis of the ultrasound treated hairless mice. CONCLUSION: Ultrasound can increase mRNA of lipids synthetic enzymes and lipids synthesis without increasing TEWL by changing calcium ion gradients.

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  8. [국내논문]   SADBE (Squaric acid dibutylester) Immunotherapy in Alopecia Areata  

    Kwon, Kyung Sool , Kim, Moon Bum , Kwon, Yoo Wook , Park, Hyun Je , Oh, Chang Keun , Jang, Ho Sun
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.5 ,pp. 630 - 637 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: To date, highly variable results for use of topical Squaric acid dibutylester (SADBE) in the treatment of alopecia areata have been reported. Furthermore, there are no reports on SADBE in Korean dermatologic literature yet. OBJECTIVE: The purpose of this study was to evaluate the efficacy and the tolerability of SADBE in the treatment of severe alopecia areata. METHOD: A total of 22 cases of severe alopecia areata were enrolled in this study. After sensitization of the patients with 2% SADBE in acetone, the subsequent on-going treatments were done with 0.00001% to 2% SADBE with an interval of 1 to 2 weeks. The sensitization rate, the therapeutic efficacy and side effects of SADBE during the treatment course were evaluated. The efficacy was evaluated by 5 rating scales and we continued to check the recurrence of the lesions in the patients who had shown complete regrowth. RESULTS: The mean sensitization rate was 1.55. The treatment frequency at the time of initial hair regrowth ranged from 5 to 21 (mean-10.2). In the 22 patients who were treated for 6 months, more than 90% regrowth in 10 patients (45.5%) was observed, good or fair results (50-89% regrowth) in 3 patients (13.6%), and less than 49% regrowth in 9 patients (40.9%). In this study, only the duration of disease and being recurrent or not, among many prognostic factors, were statistically significant (p

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  9. [국내논문]   Combination Therapy with Pulsed Dye Laser and Intralesional Bleomycin for the Treatment of Recalcitrant Warts  

    Park, Seok Yeol , Kim, Chang Duk , Kim, Chang Wook , Lee, Kyu Suk
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.5 ,pp. 638 - 642 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Some warts prove resistant to multiple therapies, particularly on an immunosuppressed patient. A previous study revealed that combination therapy with pulsed dye laser and intralesional bleomycin was effective on recalcitrant warts. OBJECTIVE: The aim of this study was to confirm whether the combination therapy with pulsed dye laser and intralesional bleomycin was effective for the treatment of recalcitrant warts. METHOD: Fifteen patients, all with recalcitrant warts, were recruited. Two patients were on long-term immunosuppressant drugs. Twenty warts were treated in total. The warts were anaesthetized with local anesthetic cream (EMLA(R) 5% cream) then treated with a pulsed dye laser (5mm spot, fluence 9.5-10J/cm2). Immediately following this, bleomycin (1mg/ml) was injected into the base of the warts. At 3-4 weeks after the last treatment, the warts were evaluated to assess clearance rate, total treatment numbers and side effects. RESULT: 1. Complete clearance was achieved for 17 out of 20 warts (85%). 2. Partial clearance was achieved for 3 out of 20 warts (15%). 3. Recalcitrant warts were cleared with an average of 1.95 treatments. 4. Recalcitrant warts on the immunosuppressed patients were cleared with an average of 2.0 treatments. 5. No significant side effects were observed. CONCLUSION: Combination therapy with the pulsed dye laser and intralesional bleomycin appears to be a safe, rapid, well tolerated and successful treatment for recalcitrant warts. It also appears to be effective for recalcitrant warts on immunosuppressed patients.

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  10. [국내논문]   The Effects of 5% Imiquimod Cream on Verruca Plana  

    Kim, Moon Bum , Ko, Hyun Chang , Jang, Bong Seok , Kwon, Yoo Wook , Oh, Chang Keun , Jang, Ho Sun , Kwon, Kyung Sool
    大韓皮膚科學會誌 = Korean journal of dermatology v.43 no.5 ,pp. 643 - 649 , 2005 , 0494-4739 ,

    초록

    BACKGROUND: Verruca plana is a cutaneous human papillomavirus (HPV) infections. Although various treatments such as destructive methods or immunomodulating agents have been used, none are uniformly effective or prevent recurrence. Ideal treatment for verruca plana should target on an increasing local immune response to the HPV infection. Recently, imiquimod, a topical immune- response modifier, has been successfully used in the treatment of external anogenital warts. OBJECTIVE: The aim of this study was to determine the efficacy and safety of 5% imiquimod cream for the treatment of verruca plana. METHOD: Seven patients with verruca plana were treated with 5% imiquimod cream 3 times a week. at night, for 16 weeks or until complete clearance of lesions had occured. During the follow- up period, the onset time of effects, clearance rate, side effects, and recurrence rate were recorded. At 16 weeks after treatment, a clearance rate was determined by a 3 scale rating; complete-100% clearance / partial-less than 100% clearance / failure-no clearance. RESULTS: The onset time of effects ranged from 1 to 4 weeks (mean-1.7 weeks). The clearance rate at 16 weeks after treatment were as follows; complete-4 (57.1%), partial-2 (28.6%), and failure - 1 (14.2%). No patient showed systemic side effects or long-term adverse effects such as pigmentary disorders or scarring. In the subjective local skin reactions, itching was the only symptom and was common (4/7, 57.1%). With objective skin reactions, erythema was the most common (4/7, 57.1%), followed by erosion and scabbing (2/7, 28.6%). In long-term follow-up of those patients who showed complete clearance, no one encountered recurrence. CONCLUSION: This data demonstrates that 5% imiquimod cream is an effective and promising treatment modality for verruca plana. Because it is non-destructive, safe, and easy to use, it resulted in an excellent cosmetic outcome.

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