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The journal of immunology : official journal of th... 55건

  1. [해외논문]   In This Issue   SCI SCIE


    The journal of immunology : official journal of the American Association of Immunologists v.197 no.7 ,pp. 2555 - 2556 , 2016 , 0022-1767 ,

    초록

    No Air? HIF Can Help! See article p. 2646 Letting Lymphoid Progenitors In See article p. 2665 A GAP in Transendothelial Migration See article p. 2807 Blood-Borne RNA Correlates with Disease Severity in SLE See article p. 2854

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   Comment on “A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood”   SCI SCIE

    Cook, Laura (Department of Medicine, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada) , Zaunders, John J. (Immunovirology and Pathogenesis Program, The Kirby Institute, University of New South Wales, Sydney, New South Wales 2052, Australia) , Kelleher, Anthony D. (and )
    The journal of immunology : official journal of the American Association of Immunologists v.197 no.7 ,pp. 2557 - 2558 , 2016 , 0022-1767 ,

    초록

    No Air? HIF Can Help! See article p. 2646 Letting Lymphoid Progenitors In See article p. 2665 A GAP in Transendothelial Migration See article p. 2807 Blood-Borne RNA Correlates with Disease Severity in SLE See article p. 2854

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  3. [해외논문]   Response to Comment on “A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood”   SCI SCIE

    Dan, Jennifer M. (La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037) , Havenar-Daughton, Colin (La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037) , Silvestri, Guido (Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037) , Sette, Alessandro (La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037) , Crotty, Shane (La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037;)
    The journal of immunology : official journal of the American Association of Immunologists v.197 no.7 ,pp. 2558 - 2558 , 2016 , 0022-1767 ,

    초록

    No Air? HIF Can Help! See article p. 2646 Letting Lymphoid Progenitors In See article p. 2665 A GAP in Transendothelial Migration See article p. 2807 Blood-Borne RNA Correlates with Disease Severity in SLE See article p. 2854

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  4. [해외논문]   TLR4: The Winding Road to the Discovery of the LPS Receptor   SCI SCIE

    Murdock, Jessica L. , Nú , ñ , ez, Gabriel
    The journal of immunology : official journal of the American Association of Immunologists v.197 no.7 ,pp. 2561 - 2562 , 2016 , 0022-1767 ,

    초록

    No Air? HIF Can Help! See article p. 2646 Letting Lymphoid Progenitors In See article p. 2665 A GAP in Transendothelial Migration See article p. 2807 Blood-Borne RNA Correlates with Disease Severity in SLE See article p. 2854

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  5. [해외논문]   Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product. J. Immunol. 1999. 162: 3749–3752   SCI SCIE

    Hoshino, Katsuaki , Takeuchi, Osamu , Kawai, Taro , Sanjo, Hideki , Ogawa, Tomohiko , Takeda, Yoshifumi , Takeda, Kiyoshi , Akira, Shizuo
    The journal of immunology : official journal of the American Association of Immunologists v.197 no.7 ,pp. 2563 - 2566 , 2016 , 0022-1767 ,

    초록

    No Air? HIF Can Help! See article p. 2646 Letting Lymphoid Progenitors In See article p. 2665 A GAP in Transendothelial Migration See article p. 2807 Blood-Borne RNA Correlates with Disease Severity in SLE See article p. 2854

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  6. [해외논문]   Role of Metabolism in the Immunobiology of Regulatory T Cells   SCI SCIE

    Galgani, Mario (Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy) , De Rosa, Veronica (Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy) , La Cava, Antonio (Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095) , Matarese, Giuseppe (and )
    The journal of immunology : official journal of the American Association of Immunologists v.197 no.7 ,pp. 2567 - 2575 , 2016 , 0022-1767 ,

    초록

    Intracellular metabolism is central to cell activity and function. CD4 + CD25 + regulatory T cells (Tregs) that express the transcription factor FOXP3 play a pivotal role in the maintenance of immune tolerance to self. Recent studies showed that the metabolism and function of Tregs are influenced significantly by local environmental conditions and the availability of certain metabolites. It also was reported that defined metabolic programs associate with Treg differentiation, expression of FOXP3, and phenotype stabilization. This article reviews how metabolism modulates FOXP3 expression and Treg function, what environmental factors are involved, and how metabolic manipulation could alter Treg frequency and function in physiopathologic conditions.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  7. [해외논문]   Cutting Edge: Direct Sensing of TLR7 Ligands and Type I IFN by the Common Myeloid Progenitor Promotes mTOR/PI3K-Dependent Emergency Myelopoiesis   SCI SCIE

    Buechler, Matthew B. (Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101) , Akilesh, Holly M. (Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101) , Hamerman, Jessica A. (Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101;)
    The journal of immunology : official journal of the American Association of Immunologists v.197 no.7 ,pp. 2577 - 2582 , 2016 , 0022-1767 ,

    초록

    During infection, recognition of pathogens and inflammatory cytokines skews hematopoiesis toward myeloid development, although the precise mechanisms responsible for this are unclear. In this study, we show that accelerated myeloid differentiation, known as emergency myelopoiesis, involves recognition of pathogen-associated molecular patterns by the common myeloid progenitor (CMP) and is dependent on type I IFN for monocyte/macrophage differentiation. Direct sensing of TLR agonists by CMP induced rapid proliferation and induction of myeloid-differentiation genes. Lack of type I IFN signaling in CMP abrogated macrophage differentiation in response to TLR stimuli, whereas exogenous type I IFN amplified this process. Mechanistically, TLR7 induced PI3K/mammalian target of rapamycin signaling in CMP, which was enhanced by type I IFN, and this pathway was essential for emergency myelopoiesis. This work identifies a novel mechanism by which TLR and type I IFN synergize to promote monocyte/macrophage development from hematopoietic progenitors, a process critical in triggering rapid immune responses during infection.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  8. [해외논문]   Cutting Edge: IgE Plays an Active Role in Tumor Immunosurveillance in Mice   SCI SCIE

    Nigro, Elisa A. (Division of Genetics and Cell Biology, IRCCS, San Raffaele Scientific Institute, 20132 Milan, Italy) , Brini, Anna T. (Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università) , Yenagi, Vijay A. (degli Studi di Milano, 20133 Milan, Italy) , Ferreira, Lorena M. (Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università) , Achatz-Straussberger, Gertrude (degli Studi di Milano, 20133 Milan, Italy) , Ambrosi, Alessandro (Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università) , Sanvito, Francesca (degli Studi di Milano, 20133 Milan, Italy) , Soprana, Elisa (Department of Molecular Biology, Christian Doppler Laboratory for Allergy Diagnosis and Therapy, University of Salzburg, 5020 Salzburg, Austria) , van Anken, Eelco (Vita-Salute San Raffaele University, 20132 Milan, Italy) , Achatz, Gernot (Department of Pathology, IRCCS, San Raffaele Scientific Institute, 20132 Milan, Italy) , Siccardi, Antonio G. (Division of Genetics and Cell Biology, IRCCS, San Raffaele Scientific Institute, 20132 Milan, Italy) , Vangelista, Luca (Division of Genetics and Cell Biology, IRCCS, San Raffaele Scientific Institute, 20132 Milan, Italy)
    The journal of immunology : official journal of the American Association of Immunologists v.197 no.7 ,pp. 2583 - 2588 , 2016 , 0022-1767 ,

    초록

    Exogenous IgE acts as an adjuvant in tumor vaccination in mice, and therefore a direct role of endogenous IgE in tumor immunosurveillance was investigated. By using genetically engineered mice, we found that IgE ablation rendered mice more susceptible to the growth of transplantable tumors. Conversely, a strengthened IgE response provided mice with partial or complete resistance to tumor growth, depending on the tumor type. By genetic crosses, we showed that IgE-mediated tumor protection was mostly lost in mice lacking FcεRI. Tumor protection was also lost after depletion of CD8 + T cells, highlighting a cross-talk between IgE and T cell–mediated tumor immunosurveillance. Our findings provide the rationale for clinical observations that relate atopy with a lower risk for developing cancer and open new avenues for the design of immunotherapeutics relevant for clinical oncology.

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    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Influence of Extracellular RNAs, Released by Rheumatoid Arthritis Synovial Fibroblasts, on Their Adhesive and Invasive Properties   SCI SCIE

    Zimmermann-Geller, Birgit (Department of Internal Medicine and Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, 61231 Bad Nauheim, Germany) , Kö (Department of Internal Medicine and Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, 61231 Bad Nauheim, Germany) , ppert, Sina (Department of Biochemistry, Medical School, Justus Liebig University Giessen, 35392 Giessen, Germany) , Fischer, Silvia (Department of Biochemistry, Medical School, Justus Liebig University Giessen, 35392 Giessen, Germany) , Cabrera-Fuentes, Hector A. (Department of Internal Medicine and Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, 61231 Bad Nauheim, Germany) , Lefè (Department of Orthopedics and Orthopedic Surgery, University Hospital Giessen and Marburg, 35392 Giessen, Germany) , vre, Stephanie (Laboratory for Experimental Orthopedics, Department of Orthopedics and Orthopedic Surgery, University Hospital Giessen and Marburg, 35392 Giessen, Germany) , Rickert, Markus (Department of Orthopedics and Trauma Surgery, Markus Hospital, 60431 Frankfurt, Germany) , Steinmeyer, Jü (Department of Vascular Surgery) , rgen , Rehart, Stefan , Umscheid, Thomas , Schö , nburg, Markus , Mü , ller-Ladner, Ulf , Preissner, Klaus T. , Frommer, Klaus W. , Neumann, Elena
    The journal of immunology : official journal of the American Association of Immunologists v.197 no.7 ,pp. 2589 - 2597 , 2016 , 0022-1767 ,

    초록

    Extracellular RNA (exRNA) has been characterized as a molecular alarm signal upon cellular stress or tissue injury and to exert biological functions as a proinflammatory, prothrombotic, and vessel permeability–regulating factor. In this study, we investigated the contribution of exRNA and its antagonist RNase1 in a chronic inflammatory joint disease, rheumatoid arthritis (RA). Upon immunohistochemical inspection of RA, osteoarthritis (OA), and psoriatic arthritis synovium, exRNA was detectable only in the RA synovial lining layer, whereas extracellular DNA was detectable in various areas of synovial tissue. In vitro, exRNA (150–5000 nt) was released by RA synovial fibroblasts (RASF) under hypoxic conditions but not under normoxia or TNF-α treatment. RNase activity was increased in synovial fluid from RA and OA patients compared with psoriatic arthritis patients, whereas RNase activity of RASF and OASF cultures was not altered by hypoxia. Reduction of exRNA by RNase1 treatment decreased adhesion of RASF to cartilage, but it had no influence on their cell proliferation or adhesion to endothelial cells. In vivo, treatment with RNase1 reduced RASF invasion into coimplanted cartilage in the SCID mouse model of RA. We also analyzed the expression of neuropilins in synovial tissue and SF, as they may interact with vascular endothelial growth factor signaling and exRNA. The data support the concepts that the exRNA/RNase1 system participates in RA pathophysiology and that RASF are influenced by exRNA in a prodestructive manner.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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  10. [해외논문]   ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid   SCI SCIE

    Aggelakopoulou, Maria (Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens 115 27, Greece) , Kourepini, Evangelia (Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens 115 27, Greece) , Paschalidis, Nikolaos (Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens 115 27, Greece) , Simoes, Davina C. M. (Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens 115 27, Greece) , Kalavrizioti, Dimitra (Division of Hematology, Department of Internal Medicine, University of Patras Medical School, Rion 265 00, Greece) , Dimisianos, Nikolaos (and ) , Papathanasopoulos, Panagiotis (Department of Neurology, Patras University Hospital, Patras 265 00, Greece ) , Mouzaki, Athanasia (Department of Neurology, Patras University Hospital, Patras 265 00, Greece ) , Panoutsakopoulou, Vily (Division of Hematology, Department of Internal Medicine, University of Patras Medical School, Rion 265 00, Greece)
    The journal of immunology : official journal of the American Association of Immunologists v.197 no.7 ,pp. 2598 - 2609 , 2016 , 0022-1767 ,

    초록

    Multiple sclerosis (MS), an autoimmune disease of the CNS, is mediated by autoreactive Th cells. A previous study showed that the neurosteroid dehydroepiandrosterone (DHEA), when administered preclinically, could suppress progression of relapsing-remitting experimental autoimmune encephalomyelitis (EAE). However, the effects of DHEA on human or murine pathogenic immune cells, such as Th17, were unknown. In addition, effects of this neurosteroid on symptomatic disease, as well as the receptors involved, had not been investigated. In this study, we show that DHEA suppressed peripheral responses from patients with MS and reversed established paralysis and CNS inflammation in four different EAE models, including the 2D2 TCR-transgenic mouse model. DHEA directly inhibited human and murine Th17 cells, inducing IL-10–producing regulatory T cells. Administration of DHEA in symptomatic mice induced regulatory CD4 + T cells that were suppressive in an IL-10–dependent manner. Expression of the estrogen receptor β by CD4 + T cells was necessary for DHEA-mediated EAE amelioration, as well as for direct downregulation of Th17 responses. TGF-β1 as well as aryl hydrocarbon receptor activation was necessary for the expansion of IL-10–producing T cells by DHEA. Thus, our studies demonstrate that compounds that inhibit pathogenic Th17 responses and expand functional regulatory cells could serve as therapeutic agents for autoimmune diseases, such as MS.

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    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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