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저널/프로시딩 상세정보

권호별목차 / 소장처보기

H : 소장처정보

T : 목차정보

藥劑學會誌 = Journal of Korean pharmaceutical sciences 8건

  1. [국내논문]   경피제제로서 수종의 플루비프로펜 Vehicle과 O/W 마이크로에멀젼의 평가  

    이계원 (충남대학교 약학대학 ) , 지웅길 (충남대학교 약학대학)
    藥劑學會誌 = Journal of Korean pharmaceutical sciences v.28 no.3 ,pp. 141 - 149 , 1998 , 0259-2347 ,

    초록

    In order to reduce systemic side effects following administration, flurbiprofen was formulated as O/W microemulsion consisting of the surfactant, oil phase and aqueous phase. Particle size distribution, apparent viscosity, solubility and skin permeation of flurbiprofen in various vehicles and microemulsion were evaluated. The domain of O/W microemulsion s phase diagram had difference between oil types and the area of O/W microemulsion was wide distributed by adding to PG and cosurfactant than that of water alone. As increasing 10, 15 and 20% of Brij 97 content and 1, 2.5, 5% of oil content, the solubility of flurbiprofen in O/W microemulsions and various vehicles was $400{\sim}1,000$ and $10{\sim}500$ times higher than that of control. Also, apparent viscosity of soybean oil microemulsions was higher than that of IPM microemulsions and that of vehicle were increased as increasing vehicle content. Since skin permeation of flurbiprofen decreased as increasing viscosity, in each vehicle, it was not affected 2% ${\beta}-CD$ and decreased as increasing PG content and to 2, 5 and 10% of $HP-{\beta}-CD$ . In O/W microemulsion, 5% soybean oil. 20% Brij 97 and 75% water(A-1) with high viscosity showed low skin penetration.

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  2. [국내논문]   키토산을 함유한 알긴산 칼슘 마이크로캅셀의 항균효과  

    양재헌 (우석대학교 약학대학 ) , 임종필 (우석대학교 약학대학)
    藥劑學會誌 = Journal of Korean pharmaceutical sciences v.28 no.3 ,pp. 151 - 158 , 1998 , 0259-2347 ,

    초록

    The inhibition rate of bacteria growth per molecular weight was higher according as the molecular weight increased, the rate was the highest at the molecular weight 200,000. Microcapsule of ionized calcium was able to be produced by molecular weight 15,000, 30,000, 50,000 and 200,000 of chitosan which was dried for 48 hours after melting it in 2% of acetic acid, adding ionized calcium and controlling pH 1.2. The size of ionized calcium microcapsule was between 200 and $300\;{\mu}m$ , the solvency, concentration and the content showed big difference by the molecular weight of chitosan. The inhibition rate of bacteria growth of microcapsule designated high in Gram positive, which was high in S. aureus, S. epidermidis and Bacillus subtilis, low in S. mutans, high in C. albicans in fungi, low in A. niger. The inhibition rate of bacteria growth of chitosan was comparatively high in Gram positive, low in S. mutans and it showed high numerical value in C. albicans of fungi. The rate recorded good result at molecular weight 200,000 relatively, there was no difference according to the molecular weight. The inhibition rate of bacteria growth according to the concentration of the microcapsule increased differently between $1.000{\sim}10,000\;{\mu}g/ml$ , it showed antibacterial activity close to the inhibition rate of growth of chitosan rather than ionized calcium. The minimum inhibitory concentration marked the highest in the mixture of chitosan and ionized calcium for all kind of bacteria generally, there was a little difference between yeast and fungi.

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  3. [국내논문]   바이칼린을 함유한 황금 엑스 유제의 제조 및 항균효과  

    양재헌 (우석대학교 약학대학 ) , 김영일 (우석대학교 약학대학)
    藥劑學會誌 = Journal of Korean pharmaceutical sciences v.28 no.3 ,pp. 159 - 164 , 1998 , 0259-2347 ,

    초록

    The O/W and W/O emulsions containing Scutellariae Radix extract(SRE) which is very slightly soluble in oil phases and sparingly soluble in water phases, were prepared by homogenizing water and oil phases with emulsifier. The diameters of emulsion were ranged from 100 to $300\;{\mu}m$ . The viscosity of W/O emulsion was higher than that of O/W emulsion. W/O emulsion was more stable than O/W emulsion which was gradually degraded when tested by centrifuge method and temperature tolerance method at $50^{\circ}C$ . The antibacterial activity of two emulsions was not significantly different from that of aqueous solution of SRE, and showed similar MIC and bacterial growth inhibition rate.

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  4. [국내논문]   케토프로펜의 피부투과도를 증진시키는 다양한 용매의 작용기전  

    조영주 (조선대학교 약학대학 ) , 최후균 (조선대학교 약학대학)
    藥劑學會誌 = Journal of Korean pharmaceutical sciences v.28 no.3 ,pp. 165 - 169 , 1998 , 0259-2347 ,

    초록

    The effect of various vehicles on the permeation of a model drug, ketoprofen in solution formulation was evaluated using a flow-through diffusion cell system at $37^{\circ}C$ . To investigate the mechanism of permeation rate enhancement, the effects of pretreatment with various vehicles on the permeation of the drug were evaluated using 5 mg/ml solution and saturated solution. The order of permeation rate of ketoprofen across hairless mouse skin after pretreatment with various vehicles was similar to the case where the vehicles and the drug were coadministered except ethanol and oleic acid. The results indicate that the mechanism of enhancement can be direct action of the vehicles on the barrier property of the skin and/or carrier mechanism.

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  5. [국내논문]   새로운 백금 착체(II) 화합물의 흰쥐 혈장에서 대사체 확인  

    김종환 (경희대학교 약학대학 ) , 조요나 (경희대학교 약학대학 ) , 노영수 (경희대학교 약학대학 ) , 서성훈 (경희대학교 약학대학 ) , 정지창 (경희대학교 의과대학 ) , 장성구 (경희대학교 의과대학 ) , 이규홍 (보령제약 중앙연구소 ) , 이주한 (보령제약 중앙연구소 ) , 이경태 (경희대학교 약학대학)
    藥劑學會誌 = Journal of Korean pharmaceutical sciences v.28 no.3 ,pp. 171 - 175 , 1998 , 0259-2347 ,

    초록

    KHPC-002 $[(trans-l-diaminocyclohexane-bis-l,2(diphenylphosphinoethane)platinum)\;{\cdot}2NO_3]$ and $KHPC-006[(cis-diaminocyclohexane-bis-1,2(diphenylphosphinoethane)platinum)\;{\cdot}2NO_3]$ were synthesized as candidates for third platinum antitumor agent. Before their pharmacokinetic study, we optimized the analytical condition with HPLC and identified the major metabolites in the rat plasma. HPLC analysis by $C_{18}$ reverse-phase column showed that standard peak of both compounds appeared rapidly at around 1 minutes, whereas metabolites of KHPC-002 and KHPC-006 which were extracted from plasma after single I.V. administration in rats or incubation for 24 hr at $37^{\circ}C$ showed retention time of $10{\sim}11$ minutes. These metabolites were identified as the major compound by Matrix Associated Laser Deposition/Ionization (MALDI), which only lose the 2 molecules of $NO_3$ . Based on these results, we suggest that the major metabolites of KHPC-002 and KHPC-006 were [trans-l-diamino-cyclohexane-bis-l,2(diphenylphosphinoethane)platinum] and [cis-diaminocyclohexane-bis-l.2(diphenylphosphinoethane)platinum], respectively.

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  6. [국내논문]   코지산을 함유한 폴록사머 겔 제제의 약물방출 및 피부자극성  

    박은우 (중앙대학교 약학대학 ) , 조성완 (중앙대학교 약학대학 ) , 김동섭 (국립독성연구소 약효약리과 ) , 최기환 (국립독성연구소 약효약리과 ) , 최영욱 (중앙대학교 약학대학)
    藥劑學會誌 = Journal of Korean pharmaceutical sciences v.28 no.3 ,pp. 177 - 183 , 1998 , 0259-2347 ,

    초록

    Low toxicity, reverse thermal gelation and high drug loading capabilities suggest that poloxamer 407 gels have great potential as a topical drug delivery system. Kojic acid (KA) is an antimelanogenic agent which has been widely used in cosmetics to whiten the skin color. However, it has the drawbacks of skin irritancy due to its acidic pH. Poloxamer gels of different polymer contents were formulated to overcome the problem and compared to the cream type formulations of either w/o/w multiple emulsion cream or o/w type emulsion cream. Using Franz diffusion cells mounted with a synthetic cellulose membrane (MWCO 12,000), drug release characteristics of the formulations were evaluated by the HPLC assay of KA concentration in the receptor compartment of pH 7.4 phosphate buffered saline solutions. Drug release from w/o/w multiple emulsion cream was controlled by oil membrane, showing the apparent zero order release kinetics. The KA release from the poloxamer gels was also controlled by the gel matrix, showing that drug release increased linearly as KA contents increase, but decreased exponentially as the polymer contents increase. In the skin irritancy test, the primary irritancy index(PII) of poloxamer gel base was lower than those of multiple emulsion cream base and o/w cream. Depending on KA contents or polymer contents in the gel. PH values in poloxamer gels were ranged from 1.3 to 2.0, which are interpreted as low or negligible irritation on skin. There was a good correlation between the log value of flux in drug release and PII value in skin irritation. It was possible to conclude that the poloxamer gels containing KA might be a good candidate for an antimelanogenic topical delivery system by virtue of the controlled release of the drug and the reduced skin irritancy.

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  7. [국내논문]   록소닌 정(록소프로펜 나트륨 무수물 60 mg)에 대한 록시펜 정의 생물학적 동등성  

    김인화 (서울대학교 약학대학 ) , 한태규 (서울대학교 약학대학 ) , 김경식 (순화병원 ) , 정석재 (서울대학교 약학대학 ) , 이민화 (서울대학교 약학대학 ) , 심창구 (서울대학교 약학대학)
    藥劑學會誌 = Journal of Korean pharmaceutical sciences v.28 no.3 ,pp. 185 - 191 , 1998 , 0259-2347 ,

    초록

    A bioequivalence study of the Loxipen tablets (Dae Wha Pharmaceutical Co., Korea) to the Loxonin tablets (Dong Hwa Pharmaceutical Co., Korea), formulations of sodium loxoprofen anhydrous 60 mg, was conducted. Sixteen healthy Korean male subjects received each formulation at the dose of 60 mg as sodium loxoprofen anhydrous in a $2{\times}2$ crossover study. There was a 2-week washout period between the dose. Plasma concentrations of loxoprofen were monitored by an HPLC method for over a period of 6 h after each administration. AUC (area under the plasma concentration-time curve from time zero to infinity) was calculated by the linear trapezoidal and extrapolation method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ $(time\;to\;reach\;C_{max})$ were compiled from the plasma drug concentration-time data. Analysis of variance (ANOVA) revealed that there are no differences in AUC, $C_{max}$ and $T_{max}$ between the formulations. The apparent differences between the formulations in these parameters were all far less than 20% (i.e., 5.88, 7.81 and 6.09% for AUC, $C_{max}$ and $T_{max}$ , respectively). Minimum detectable differences (%) at ${\alpha}=0.1$ and $1-{\beta}=0.8$ were all less than 20% difference in these parameters between the formulations were all over 0.8 (i.e., 15.81, 13.13 and 19.85 for AUC, $C_{max}$ and $T_{max}$ , respectively). The 90% confidence intervals for these parameters were also within ${\pm}20%$ (i.e., $-16.52{\sim}4.77$ , $-16.65{\sim}1,02$ and $-19.45{\sim}7.28%$ for AUC, $C_{max}$ and $T_{max}$ , respectively). These results satisfy the bioequivalence criteria of the Korea Food and Drug Administration (KFDA) guidelines (No. 98-51). Therefore, these results indicate that the 2 formulations of loxoprofen are bioequivalent and, thus, may be prescribed interchangeably.

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  8. [국내논문]   프레탈 정(시로스타졸 50 mg)에 대한 로사졸 정의 생물학적 동등성  

    김수진 (전남대학교 약학대학/약품개발연구소 ) , 임동구 (전남대학교 약학대학/약품개발연구소 ) , 오인준 (전남대학교 약학대학/약품개발연구소 ) , 조행남 (전남대학교 병원 약제부 ) , 서순팔 (전남대학교 의과대학 ) , 이용복 (전남대학교 약학대학/약품개발연구소)
    藥劑學會誌 = Journal of Korean pharmaceutical sciences v.28 no.3 ,pp. 193 - 198 , 1998 , 0259-2347 ,

    초록

    Bioequivalence of two cilostazol tablets, the $Pletaal^{TM}$ (Korea Otsuka Pharmaceutical Co., Ltd.) and the $Losazol^{TM}$ (Kyoung Dong Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age $20{\sim}28$ years old) were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After two tablets containing 50 mg of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters $(C_{max},\;T_{max}\;and\;AUC_t)$ were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in $C_{max},\;T_{max}\;and\;AUC_t$ between two tablets were 3.14%, 10.0% and 7.35%, respectively. The powers $(1-{\beta})$ for $C_{max},\;T_{max}\;and\;AUC_t$ were 89.67%, 80.97% and 83.87%, respectively. Detectable differences $({\Delta})$ and confidence intervals were all less than 20% except $T-{max}$ , but confidence interval of $T_{max}$ was also less than 20% at the significance $level({\alpha})$ of 0.1. All of these parameters met the criteria of KFDA for bioequivalence, indicating that $Losazol^{TM}$ tablet is bioequivalent to $Pletaal^{TM} tablet$ .

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