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Journal of cellular physiology 78건

  1. [해외논문]   Cover Image, Volume 233, Number 10, October 2018  


    Journal of cellular physiology v.233 no.10 ,pp. i - i , 2018 , 0021-9541 ,

    초록

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  2. [해외논문]   Table of Contents, Editor's Choice, Highlights  


    Journal of cellular physiology v.233 no.10 ,pp. 6305 - 6316 , 2018 , 0021-9541 ,

    초록

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Cell tracking, survival, and differentiation capacity of adipose‐derived stem cells after engraftment in rat tissue  

    Muñ (Departamento de Bioquímica y Biología Molecular, Universidad de Sevilla, Sevilla, Spain) , oz, Mario F. (Departamento de Fisiología, Universidad de Sevilla, Sevilla, Spain) , Argü (Departamento de Nutrición, Bromatología, Toxicología y Medicina Legal, . Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain) , elles, Sandro (Departamento de Nutrición, Bromatología, Toxicología y Medicina Legal, . Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain) , Guzman‐ (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Departamento de Señalización Celular, Universidad de Sevilla, Sevilla, Spain) , Chozas, Matias (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Departamento de Señalización Celular, Universidad d) , Guillé , n‐ , Sanz, Remedios , Franco, Jaime M. , Pintor‐ , Toro, José , A. , Cano, Mercedes , Ayala, Antonio
    Journal of cellular physiology v.233 no.10 ,pp. 6317 - 6328 , 2018 , 0021-9541 ,

    초록

    Adipose tissue is an important source of adipose derived stem cells (ADSCs). These cells have the potential of being used for certain therapies, in which the main objective is to recover the function of a tissue/organ affected by a disease. In order to contribute to repair of the tissue, these cells should be able to survive and carry out their functions in unfavorable conditions after being transplanted. This process requires a better understanding of the biology involved: such as the time cells remain in the implant site, how long they stay there, and whether or not they differentiate into host tissue cells. This report focuses on these questions. ADSC were injected into three different tissues (substantia nigra, ventricle, liver) and they were tracked in vivo with a dual GFP‐Luc reporter system. The results show that ADSCs were able to survive up to 4 months after the engraftment and some of them started showing resident cell tissue phenotype. These results demonstrate their long‐term capacity of survival and differentiation when injected in vivo.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Early endplate remodeling and skeletal muscle signaling events following rat hindlimb suspension  

    Chibalin, Alexander V. (Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden) , Benziane, Boubacar (Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden) , Zakyrjanova, Guzalija F. (Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia) , Kravtsova, Violetta V. (Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia) , Krivoi, Igor I. (Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia)
    Journal of cellular physiology v.233 no.10 ,pp. 6329 - 6336 , 2018 , 0021-9541 ,

    초록

    Motor endplates naturally undergo continual morphological changes that are altered in response to changes in neuromuscular activity. This study examines the consequences of acute (6–12 hr) disuse following hindlimb suspension on rat soleus muscle endplate structural stability. We identify early changes in several key signaling events including markers of protein kinase activation, AMPK phosphorylation and autophagy markers which may play a role in endplate remodeling. Acute disuse does not change endplate fragmentation, however, it decreases both the individual fragments and the total endplate area. This decrease was accompanied by an increase in the mean fluorescence intensity from the nicotinic acetylcholine receptors which compensate the endplate area loss. Muscle disuse decreased phosphorylation of AMPK and its substrate ACC, and stimulated mTOR controlled protein synthesis pathway and stimulated autophagy. Our findings provide evidence that changes in endplate stability are accompanied by reduced AMPK phosphorylation and an increase in autophagy markers, and these changes are evident within hours of onset of skeletal muscle disuse.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   Baseline neutrophilia, derived neutrophil‐to‐lymphocyte ratio (dNLR), platelet‐to‐lymphocyte ratio (PLR), and outcome in non small cell lung cancer (NSCLC) treated with Nivolumab or Docetaxel  

    Russo, Alessandro (Medical Oncology Unit A.O. Papardo & Department of Human Pathology, University of Messina, Messina, Italy) , Franchina, Tindara (Medical Oncology Unit A.O. Papardo & Department of Human Pathology, University of Messina, Messina, Italy) , Ricciardi, Giuseppina R.R. (Medical Oncology Unit A.O. Papardo & Department of Human Pathology, University of Messina, Messina, Italy) , Battaglia, Alessandra (Medical Oncology Unit A.O. Papardo & Department of Human Pathology, University of Messina, Messina, Italy) , Scimone, Antonino (Medical Oncology Unit A.O. Papardo & Department of Human Pathology, University of Messina, Messina, Italy) , Berenato, Rosa (Medical Oncology Unit A.O. Papardo & Department of Human Pathology, University of Messina, Messina, Italy) , Giordano, Antonio (Department of Medicine, Surgery and Neuroscience, University of Siena and Istituto Toscano Tumori (ITT), Siena, Italy<countr) , Adamo, Vincenzo
    Journal of cellular physiology v.233 no.10 ,pp. 6337 - 6343 , 2018 , 0021-9541 ,

    초록

    Nivolumab is a novel therapeutic option in NSCLC, associated with a significant survival gain compared with Docetaxel. However, predictive biomarkers are lacking. The presence of systemic inflammation has been correlated with poor outcome in many cancer types. We aimed to evaluate whether there is a correlation between some indicators of inflammation and response to Nivolumab or Docetaxel in pre‐treated NSCLCs. Data of 62 patients receiving Nivolumab or Docetaxel were analyzed. Baseline neutrophilia and thrombocytosis were not associated with response. High dNLR was associated with no response to Nivolumab, but not with Docetaxel, whereas high PLR correlated with low treatment response in both groups. Among refractory patients, a higher incidence of thrombocytosis, neutrophilia, high PLR, and high dNLR levels were observed compared with the overall population. This is one of the first reports in this field and suggests that indicators of inflammation might be included together with other predictive biomarkers in the baseline evaluation of patients candidate for immunotherapy.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Protective effect of miR378* on doxorubicin‐induced cardiomyocyte injury via calumenin  

    Wang, Yu (Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China) , Cui, Xiaoxue (Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China) , Wang, Yilin (Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China) , Fu, Yao (Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China) , Guo, Xin (Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China) , Long, Jie (Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China) , Wei, Chengxi (Medicinal Chemistry and Pharmacology Institute, Inner M) , Zhao, Ming
    Journal of cellular physiology v.233 no.10 ,pp. 6344 - 6351 , 2018 , 0021-9541 ,

    초록

    Doxorubicin (Dox) is a highly effective antitumor antibiotic, however myocardial toxicity severely limits its use clinically. The pathogenesis of doxorubicin‐induced cardiomyopathy is unclear. In Dox cardiomyopathy mice, there is a decline in cardiac function, a change in myocardial pathology and a reduction in miR378* expression. Expression changes in calumenin, an endoplasmic reticulum stress (ERS) chaperone protein and pathway factor, as well as apoptosis, were observed in cardiomyocytes after doxorubicin‐induced injury. However, miR378* increased calumenin expression, eased ERS, and reduced cardiomyocyte apoptosis, while, silencing miR378* reduced calumenin expression, aggravated ERS, and increased cardiomyocyte apoptosis. The above results indicate that miR378* alleviates ERS and inhibits the activation of the ERS‐mediated apoptosis signaling pathway in cardiomyocytes via regulating calumenin expression, thereby reducing cardiomyocyte apoptosis after doxorubicin‐induced injury. Increasing miR378* expression may be a new way to improve cardiac function and quality of life in patients with Dox cardiomyopathy.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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    Fig. 1 이미지
  7. [해외논문]   Gp78 involvement in cellular proliferation: Can act as a promising modulator for cell cycle regulatory proteins?  

    Joshi, Vibhuti (Cellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Rajasthan, India) , Upadhyay, Arun (Cellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Rajasthan, India) , Chhangani, Deepak (Cellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Rajasthan, India) , Amanullah, Ayeman (Cellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Rajasthan, India) , Sharan, Rajesh N. (Radiation and Molecular Biology Unit, Department of Biochemistry, North‐Eastern Hill University, Shillong, Meghalaya, India) , Mishra, Amit (Cellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Rajasthan, India)
    Journal of cellular physiology v.233 no.10 ,pp. 6352 - 6368 , 2018 , 0021-9541 ,

    초록

    In cells, protein synthesis and degradation are normal processes, which are tightly regulated by various cellular metabolic pathways. Cellular protein quality control (PQC) mechanisms always present a continuous and rigorous check over all intracellular proteins before they can participate in various cellular physiological processes with the help of PQC pathways like autophagy and ubiquitin proteasome system (UPS). The UPS employs few selective E3 ubiquitin ligases for the intracellular degradation of cyclin‐dependent kinase inhibitor 1B (p27 Kip1 ) that tightly controls cell cycle progression. But, the complex mechanistic interactions and the interplay between E3 ubiquitin ligases involved in the functional regulation as well as expression of p27 are not well known. Here, we demonstrate that cell surface glycoprotein Gp78, a putative E3 ubiquitin ligase, is involved in the stabilization of intracellular steady‐state levels of p27. Transient overexpression of Gp78 increases the accumulation of p27 in cells in the form of massive inclusions like structures, which could be due to its cumulative increased stability in cells. We have also monitored how under stress condition, E3 ubiquitin ligase Gp78 regulates endogenous levels of p27 in cells. ER stress treatment generates a marginal increase in Gp78 endogenous levels, and this elevation effect was prominent for intracellular accumulation of p27 in cells. Taken together, our current findings suggest a valuable multifactorial regulatory mechanism and linkage of p27 with UPS pathway.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   A new gold standard approach to characterize the transport of Si across cell membranes in animals  

    Garneau, Alexandre P. (The Nephrology Research Group, Department of Medicine, Laval University, Québec, Canada) , Marcoux, André (The Nephrology Research Group, Department of Medicine, Laval University, Québec, Canada) , e‐ (The Nephrology Research Group, Department of Medicine, Laval University, Québec, Canada) , Anne (Horticulture Research Group, Phytology Department, Laval University, Pavillon Paul‐Comtois, Québec, Canada) , Frenette‐ (The Nephrology Research Group, Department of Medicine, Laval University, Québec, Canada) , Cotton, Rachelle , Bé , langer, Richard , Isenring, Paul
    Journal of cellular physiology v.233 no.10 ,pp. 6369 - 6376 , 2018 , 0021-9541 ,

    초록

    Silicon (Si) is increasingly recognized as an essential trace element in animals, especially since the identification of mammalian Si transport systems and Si responsive genes not long ago. During many years, however, efforts to gain substantial insight into the biological role of this element in animals have achieved partial success due in part to the unavailability of validated protocols to study Si movement across biological membranes. To circumvent such limitations, we have developed a general transport assay in which cellular Si content was determined by automated electrothermal atomic absorption spectrophotometry. We have found this assay to provide great analytic sensitivity with Si detection thresholds of less than 1 μM, that is, below or very close to the concentration range of animal cells. We have also found this assay to provide valid and cost‐effective determinations in Si transport studies while requiring workable quantities of samples. The protocol described here should thus become gold standard toward accelerated progress in the field of Si transport.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Beyond voltage‐gated ion channels: Voltage‐operated membrane proteins and cellular processes  

    Zhang, Jianping (Department of Pharmacology, Hebei University of Chinese Medicine, Shijiazhuang, China) , Chen, Xingjuan (Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana ) , Xue, Yucong (Department of Pharmacology, Hebei University of Chinese Medicine, Shijiazhuang, China) , Gamper, Nikita (Faculty of Biological Sciences, University of Leeds, Leeds, UK) , Zhang, Xuan (Department of Pharmacology, Hebei University of Chinese Medicine, Shijiazhuang, China)
    Journal of cellular physiology v.233 no.10 ,pp. 6377 - 6385 , 2018 , 0021-9541 ,

    초록

    Voltage‐gated ion channels were believed to be the only voltage‐sensitive proteins in excitable (and some non‐excitable) cells for a long time. Emerging evidence indicates that the voltage‐operated model is shared by some other transmembrane proteins expressed in both excitable and non‐excitable cells. In this review, we summarize current knowledge about voltage‐operated proteins, which are not classic voltage‐gated ion channels as well as the voltage‐dependent processes in cells for which single voltage‐sensitive proteins have yet to be identified. Particularly, we will focus on the following. (1) Voltage‐sensitive phosphoinositide phosphatases (VSP) with four transmembrane segments homologous to the voltage sensor domain (VSD) of voltage‐gated ion channels; VSPs are the first family of proteins, other than the voltage‐gated ion channels, for which there is sufficient evidence for the existence of the VSD domain; (2) Voltage‐gated proton channels comprising of a single voltage‐sensing domain and lacking an identified pore domain; (3) G protein coupled receptors (GPCRs) that mediate the depolarization‐evoked potentiation of Ca 2+ mobilization; (4) Plasma membrane (PM) depolarization‐induced but Ca 2+ ‐independent exocytosis in neurons. (5) Voltage‐dependent metabolism of phosphatidylinositol 4,5‐bisphosphate (PtdIns[4,5]P 2 , PIP 2 ) in the PM. These recent discoveries expand our understanding of voltage‐operated processes within cellular membranes.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [해외논문]   N1‐methylnicotinamide (MNAM) as a guardian of cardiovascular system  

    Nejabati, Hamid Reza (Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran) , Mihanfar, Aynaz (Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran) , Pezeshkian, Masoud (Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran) , Fattahi, Amir (Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran) , latifi, Zeinab (Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran) , Safaie, Naser (Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran) , Valiloo, Mohammad (Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran) , Jodati, Ahmad Reza (Cardiovascular Research Cente) , Nouri, Mohammad
    Journal of cellular physiology v.233 no.10 ,pp. 6386 - 6394 , 2018 , 0021-9541 ,

    초록

    Atherosclerosis is identified as the formation of atherosclerotic plaques, which could initiate the formation of a blood clot in which its growth to coronary artery can lead to a heart attack. N‐methyltransferase (NNMT) is an enzyme that converts the NAM (nicotinamide) to its methylated form, N1‐methylnicotinamide (MNAM). Higher levels of MNAM have been reported in cases with coronary artery disease (CAD). Further, MNAM increases endothelial prostacyclin (PGI2) and nitric oxide (NO) and thereby causes vasorelaxation. The vasoprotective, anti‐inflammatory and anti‐thrombotic roles of MNAM have been well documented; however, the exact underlying mechanisms remain to be clarified. Due to potential role of MNAM in the formation of lipid droplets (LDs), it might exert its function in coordination with lipids, and their targets. In this study, we summarized the roles of MNAM in cardiovascular system and highlighted its possible mode of actions.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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