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The Thoracic and cardiovascular surgeon 15건

  1. [해외논문]   A Thing of Beauty is a Joy Forever   SCI SCIE

    Heinemann, Markus (Department of Cardiac, Thoracic and Vascular Surgery, Universitaetsmedizin Mainz, Mainz, Germany)
    The Thoracic and cardiovascular surgeon v.66 no.1 ,pp. 001 - 001 , 2018 , 0171-6425 ,

    초록

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  2. [해외논문]   Do We Need Basic Research in Cardiac Surgery?   SCI SCIE

    Doenst, Torsten (Department of Cardiothoracic Surgery, Friedrich Schiller University Jena, Jena, Germany ) , Schlensak, Christian (Department of Cardiothoracic and Vascular Surgery, University of Tuebingen, Tuebingen, Germany ) , Schibilsky, David (Department of Cardiothoracic and Vascular Surgery, University of Tuebingen, Tuebingen, Germany ) , Faerber, Gloria (Department of Cardiothoracic Surgery, Friedrich Schiller University Jena, Jena, Germany)
    The Thoracic and cardiovascular surgeon v.66 no.1 ,pp. 002 - 006 , 2018 , 0171-6425 ,

    초록

    Thinking about the daily practice of cardiac surgery, genetically altered mouse models, polymerase chain reactions, western blots, and other laboratory tools are the last that comes to mind. It is, therefore, not surprising that the pursuit of such basic science activities by practicing surgeons and those in training is often limited. However, there is an innate connection between these two seemingly different disciplines. To address and visualize this connection, we propose the following three hypotheses. First, cardiac surgery would not be at its present level of expertise without fundamental contributions of basic science. Second, without practicing cardiac surgeons performing basic research and translating their results to clinical practice next to their daily work, our ability to care for cardiac surgery patients would be poorer. Third, basic science training for those aiming to become practicing cardiac surgeons improves their ability to properly care for their patients. Finally, we will discuss some potentially even unexpected implications for our currently changing daily clinical practice.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [해외논문]   Data Science Meets the Clinician: Challenges and Future Directions   SCI SCIE

    Charitos, Efstratios (Department of Cardiac Surgery, University of Halle (Saale), Halle, Germany ) , Wilbring, Manuel (Department of Cardiac Surgery, University of Halle (Saale), Halle, Germany ) , Treede, Hendrik (Department of Cardiac Surgery, University of Halle (Saale), Halle, Germany)
    The Thoracic and cardiovascular surgeon v.66 no.1 ,pp. 007 - 010 , 2018 , 0171-6425 ,

    초록

    In the last three decades a profound transformation of the medical profession has taken place. The modern clinician is required to consume vast amounts of information from clinical studies, critically reviewing evidence that may or may not lead to changes in clinical practice. The present article presents some challenges that this era of information poses to clinicians and patients.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [해외논문]   Heart and Mitochondria: Pathophysiology and Implications for Cardiac Surgeons   SCI SCIE

    Niemann, Bernd (Klinik für Herz-, Kinderherz- und Gefäßchirurgie, Justus-Liebig-Universität Giessen, UKGM, Giessen, Hessen, Germany ) , Schwarzer, Michael (Department of Cardiothoracic Surgery, Friedrich Schiller University of Jena, Jena, Germany ) , Rohrbach, Susanne (Institute for Physiology, Justus Liebig University Giessen, Giessen, Germany)
    The Thoracic and cardiovascular surgeon v.66 no.1 ,pp. 011 - 019 , 2018 , 0171-6425 ,

    초록

    Excluding the heart from systemic circulation during cardiac surgery renders the myocardium ischemic, resulting in cardiac damage. In addition, another hit to the myocardium will occur upon restoration of blood flow, in the reperfusion phase. Experimental data from animal models have revealed that loss of cardiac metabolic flexibility and mitochondrial dysfunctions contributes to contractile impairment in hypertrophied, failing, obese, and diabetic hearts. Such diseased hearts are prone to myocardial ischemia–reperfusion (I/R) injury. Although analyses in human cardiac samples are not as comprehensive as animal data, similar disease-associated metabolic and mitochondrial changes exist. Considering increasing age and comorbidities in patients nowadays, it is not surprising that I/R injuries remain a major cause of morbidity and mortality after cardiac surgery. Mitochondria have emerged as critical targets but also key regulators of myocardial I/R injury, and the extent of mitochondrial damage is a major determinant of myocardial I/R injury. Although cardioprotective mechanisms are diverse, many come together and involve steps at the point of mitochondria. We will, therefore, provide a description of mitochondrial alterations observed in various cardiac disease states and discuss the current experimental knowledge of the role of mitochondria in I/R and of potential protective mechanisms against myocardial I/R injury involving mitochondria. Within this review, we will focus on the protection against I/R injury conferred by caloric restriction (CR) and by ischemic conditioning. Further research is needed to establish whether strategies targeting mitochondria, which have been proposed from preclinical studies, could be translated into cardioprotective therapies against I/R injury in patients.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [해외논문]   New Targets for the Prevention of Chronic Rejection after Thoracic Organ Transplantation   SCI SCIE

    Heim, Christian (Department of Cardiac Surgery, University of Erlangen-Nuremberg, Erlangen, Germany ) , Gocht, Annika (Department of Cardiac Surgery, University of Erlangen-Nuremberg, Erlangen, Germany ) , Weyand, Michael (Department of Cardiac Surgery, University of Erlangen-Nuremberg, Erlangen, Germany ) , Ensminger, Stephan (Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany)
    The Thoracic and cardiovascular surgeon v.66 no.1 ,pp. 020 - 030 , 2018 , 0171-6425 ,

    초록

    The gold standard for the treatment of terminal heart failure and irreversible lung diseases includes thoracic organ transplantation. The major obstacle for long-term survival after successful transplantation is chronic rejection, an ongoing immunomodulatory disease so far without effective therapy. Therefore, the aim of this review is to elucidate scientific efforts targeting different new mechanisms of cardiac allograft vasculopathy (CAV) and chronic lung allograft dysfunction (CLAD). For this purpose, we performed a systematic review of the literature to assess recent strategies in transplant immunology research. We searched MEDLINE from 2015 up to date for articles addressing the following keywords: CAV, transplant vasculopathy, transplant arteriosclerosis, CLAD, bronchiolitis obliterans transplant, and obliterative bronchiolitis transplant. All articles including experimental models in the field of transplant immunology addressing new aspects for the prevention of chronic rejection after heart and lung transplantation were included in this review. The prevention of chronic rejection would clearly improve the survival of patients after heart and lung transplantation. Interesting targets were addressed in recent research, but further research is necessary to effectively treat this life-threatening disease in transplant recipients.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [해외논문]   Mechanisms Involved in Premature Aging in the Heart—Is There an Implication for Cardiac Surgery?   SCI SCIE

    Niemann, Bernd (Department of Adult and Pediatric Cardiac and Vascular Surgery, Justus-Liebig-University Giessen, University Hospital Giessen and Marburg (UKGM), Giessen, Germany ) , Simm, Andreas (Department of Cardiac Surgery, University Hospital Halle (Saale), Halle (Saale), Germany ) , Rohrbach, Susanne (Institute for Physiology, Justus-Liebig-University Giessen, Giessen, Germany)
    The Thoracic and cardiovascular surgeon v.66 no.1 ,pp. 031 - 041 , 2018 , 0171-6425 ,

    초록

    Abstract During the past century, life expectancy has risen in Germany from 35.6 and 38.5 years in men and women (1871/1881) to 78.2 and 83.1 years (2013/2015). In recent years, the dominance of chronic diseases as major contributors to total global mortality has emerged. The incidence of cardiovascular diseases (CVD) increases in westernized societies and projected trends suggest that by 2030, CVD alone will also be responsible for more deaths in low-income countries than infectious diseases. The occurrence of CVD also seems to correlate to a further increase of biological age within westernized societies. Therefore, age-associated changes in the heart are an issue of high interest in cardiac surgery. The chronological age is a prognostic marker in some clinical scoring systems. However, it does not represent an adequate estimation of the biological age of patients or their perioperative risk. In fact, frailty might be a more powerful predictor for normal perioperative course or risk escalation. An unhealthy, sedentary lifestyle can induce premature aging of vessels and myocardium. Understanding the age-associated genetic, biochemical, and pathophysiological changes can help identify the therapeutic capability of aged myocardium. Future “therapeutic myocardial rejuvenation” may represent a powerful tool for the stabilization of the perioperative course in aged patients. In this review, we will focus on selected mediators or conditions with impact on age-associated myocardial changes with a major focus on obesity and discuss potential therapeutic strategies to utilize or modify these mediators.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [해외논문]   Regenerative Medicine/Cardiac Cell Therapy: Adult/Somatic Progenitor Cells   SCI SCIE

    Nazari-Shafti, Timo (Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany ) , Kempfert, Jö (DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany ) , rg (DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany ) , Falk, Volkmar (Klinik für Herzchirurgie, Universitätsklinikum Bonn, Bonn, Germany ) , Rö (Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany) , ll, Wilhelm , Stamm, Christof
    The Thoracic and cardiovascular surgeon v.66 no.1 ,pp. 042 - 052 , 2018 , 0171-6425 ,

    초록

    Abstract Preclinical data suggested that somatic stem or progenitor cells derived induce and/or support endogenous repair mechanisms of the myocardium. Such cell populations were clearly shown to promote neovascularization in postischemic tissue, and some evidence also indicated transdifferentiation into cardiomyocytes. In the clinical setting, however, many attempts to regenerate damaged myocardium with a variety of autologous and allogeneic somatic progenitors have failed to generate the expected therapeutic efficacy. Currently, efforts are being made to select specific cellular subpopulations, modify somatic cells to augment their regenerative capacity, improve delivery methods, and develop markers selection of potentially responding patients. Cardiac surgical groups have pioneered and continue to advance the field of cellular therapies. While the initial excitement has subsided, the field has evolved into one of the pillars of surgical research and benefits from novel methods such as cellular reprogramming, genetic modification, and pluripotent stem cell technology. This review highlights developments and controversies in somatic cardiac cell therapy and provides a comprehensive overview of completed and ongoing clinical trials.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [해외논문]   Regenerative Medicine/Cardiac Cell Therapy: Pluripotent Stem Cells   SCI SCIE

    Duran, Ana (Universitätsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany ) , Reidell, Olivia (Universitätsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany ) , Stachelscheid, Harald (Universitätsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany ) , Klose, Kristin (Universitätsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany ) , Gossen, Manfred (Universitätsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany ) , Falk, Volkmar (DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany ) , Rö (Klinik für Herzchirurgie, Universitätsklinikum Bonn, Bonn, Nordrhein-Westfalen Germany ) , ll, Wilhelm (Universitätsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies, Berlin, Germany) , Stamm, Christof
    The Thoracic and cardiovascular surgeon v.66 no.1 ,pp. 053 - 062 , 2018 , 0171-6425 ,

    초록

    Abstract For more than 20 years, tremendous efforts have been made to develop cell-based therapies for treatment of heart failure. However, the results of clinical trials using somatic, nonpluripotent stem or progenitor cells have been largely disappointing in both cardiology and cardiac surgery scenarios. Surgical groups were among the pioneers of experimental and clinical myocyte transplantation (“cellular cardiomyoplasty”), but little translational progress was made prior to the development of cellular reprogramming for creation of induced pluripotent stem cells (iPSC). Ever since, protocols have been developed which allow for the derivation of large numbers of autologous cardiomyocytes (CMs) from patient-specific iPSC, moving translational research closer toward clinical pilot trials. However, compared with somatic cell therapy, the technology required for safe and efficacious pluripotent stem cell (PSC)-based therapies is extremely complex and requires tremendous resources and close interactions between basic scientists and clinicians. This review summarizes PSC sources, strategies to derive CMs, current cardiac tissue engineering approaches, concerns regarding immunogenicity and cellular maturity, and highlights the contributions made by surgical groups.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  9. [해외논문]   Localization of Exogenous Mesenchymal Stem Cells in a Pig Model of Lung Transplantation   SCI SCIE

    Piatkowski, Tanja (Institute of Functional and Applied Anatomy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany ) , Brandenberger, Christina (Institute of Functional and Applied Anatomy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany ) , Rahmanian, Parwis (Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Kerpener Str. 61, 50924 Cologne, Germany ) , Choi, Yeong-Hoon (Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Kerpener Str. 61, 50924 Cologne, Germany ) , Zeriouh, Mohamed (Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Kerpener Str. 61, 50924 Cologne, Germany ) , Sabashnikov, Anton (Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Kerpener Str. 61, 50924 Cologne, Germany ) , Wittwer, Thorsten (Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Kerpener Str. 61, 50924 Cologne, Germany ) , Wahlers, Thorsten (Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Kerpener Str. 61, 50924 Cologne, Germany ) , Ochs, Matthias (Institute of Functional and Applied Anatomy, Hannover Medi) , Mü , hlfeld, Christian
    The Thoracic and cardiovascular surgeon v.66 no.1 ,pp. 063 - 070 , 2018 , 0171-6425 ,

    초록

    Background Mesenchymal stem cells (MSCs) have a great potential for the treatment of acute lung injury. This study provides a detailed immunohistochemical and stereological analysis of the localization and distribution of exogenous MSC in a pig model of lung transplantation after intravascular or endobronchial application. Methods MSC derived from human bone marrow were labeled by DiI and administered intravascularly or endobronchially to the lungs of donor pigs after a period of 3 hours warm and 3 hours cold ischemia. The left lung was transplanted to a recipient pig and reperfused for 4 hours before fixation. The right donor lung was fixed for microscopic analysis directly after the ischemia time. Results After both administration routes, a similar number of exogenous MSC was found in the lungs. Within each animal, the heterogeneity of MSC distribution was high both with respect to left and right lung as well as to the different lobes of each lung. After endobronchial application, MSC were found in alveolar and bronchial/bronchiolar lumen, whereas after intravascular administration, they were mainly observed in blood vessels. Conclusion Although the administration of exogenous MSC is possible by endobronchial or intravascular application, it yields a heterogeneous distribution in the lungs which may warrant strategies to improve a more homogeneous distribution.

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    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  10. [해외논문]   Large-Animal Biventricular Working Heart Perfusion System with Low Priming Volume—Comparison between in vivo and ex vivo Cardiac Function   SCI SCIE

    Abicht, Jan-Michael (Department of Anaesthesiology, Ludwig Maximilian University, Munich, Germany ) , Mayr, Tanja (Department of Anaesthesiology, Ludwig Maximilian University, Munich, Germany ) , Jauch, Judith (Department of Anaesthesiology, Ludwig Maximilian University, Munich, Germany ) , Guethoff, Sonja (Department of Cardiac Surgery, Ludwig Maximilian University, Munich, Germany ) , Buchholz, Stefan (Department of Cardiac Surgery, Ludwig Maximilian University, Munich, Germany ) , Reichart, Bruno (Walter Brendel Center, Ludwig Maximilian University, Munich, Germany ) , Bauer, Andreas (Department of Anaesthesiology, Ludwig Maximilian University, Munich, Germany)
    The Thoracic and cardiovascular surgeon v.66 no.1 ,pp. 071 - 082 , 2018 , 0171-6425 ,

    초록

    Background Existing large-animal, ex vivo, cardiac perfusion models are restricted in their ability to establish an ischemia/reperfusion condition as seen in cardiac surgery or transplantation. Other working heart systems only challenge one ventricle or require a substantially larger priming volume. We describe a novel biventricular cardiac perfusion system with reduced priming volume. Methods Juvenile pig hearts were cardiopleged, explanted, and reperfused ex vivo after 150 minutes of cold ischemia. Autologous whole blood was used as perfusate (minimal priming volume 350 mL). After 15 minutes of Langendorff perfusion (LM), the system was switched into a biventricular working mode (WM) and studied for 3 hours. Results During reperfusion, complete unloading of both ventricles and constant-pressure coronary perfusion was achieved. During working mode perfusion, the preload and afterload pressure of both ventricles was controlled within the targeted physiologic range. Functional parameters such as left ventricular work index were reduced in ex vivo working mode (in vivo: 787 ± 186 vs. 1 h WM 498 ± 66 mm Hg·mL/g·min; p Conclusion In the ex vivo perfusion system, stable hemodynamic and metabolic conditions can be established for a period of 3 hours while functional and blood parameters are easily accessible. Moreover, because of the minimal priming volume, the novel ex vivo cardiac perfusion circuit allows for autologous perfusion, using the limited amount of blood available from the organ donating animal.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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