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Archives of pharmacal research : a publication of ... 24건

  1. [국내논문]   Effects of Opioid Pure Agonists on the Excitibility of Frog Sciatic Nerve Fibers  

    Lee, Jong-Hwa (Dept. of Pharmacy, Sahmyook University ) , Frank, George-B. (Dept. of Pharmacology, University of Alberta, Faculty of Medicine)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.16 no.2 ,pp. 83 - 88 , 1993 , 0253-6269 ,

    초록

    opioid pure agonists, morphine, meperidine and methadone, were used to investigate the effect on the opioid receptor of fron sciatic nerve fibers using sucrose gap apparatus. When applied extracellularly by perfusion, morphine, methadone and meperidine significantly depressed the amplitude of the action potential in frog sciatic nerve fibers as a dose-dependent $(10^{-10}\;M-10^{-2}\;M)$ manner. The depression with morphine or methadone was partially antagonized by the simultaueous treatment with a lower $(10^{-10}\;M-10^{-8}\;M)$ concentration of naloxone, but that of meperidine was not blocked. When the three opioid agonists were applied intracellularly by placing it in a compartment with a cut end of the sciatic nerve fibers, all of themn depressed the amplitude of the action potentials by similar potency, and these reductions significantly blocked by pretreatment of lower concentration $(10^{-10}\;M-10^{-8}M)$ of naloxone. These results support the previous findings by other workers that the stereospecific opioid receptors of this preparation are located on or near the intracellular opening of the sodium channels which are sensitive to naloxone.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

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  2. [국내논문]   Metabolism-dependent covalent binding of S(−)-3H-nicotine to lung microsomes in vitro  

    Kim, Bong Hee , Shigenaga, Mark K.
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.16 no.2 ,pp. 89 - 93 , 1993 , 0253-6269 ,

    초록

    opioid pure agonists, morphine, meperidine and methadone, were used to investigate the effect on the opioid receptor of fron sciatic nerve fibers using sucrose gap apparatus. When applied extracellularly by perfusion, morphine, methadone and meperidine significantly depressed the amplitude of the action potential in frog sciatic nerve fibers as a dose-dependent $(10^{-10}\;M-10^{-2}\;M)$ manner. The depression with morphine or methadone was partially antagonized by the simultaueous treatment with a lower $(10^{-10}\;M-10^{-8}\;M)$ concentration of naloxone, but that of meperidine was not blocked. When the three opioid agonists were applied intracellularly by placing it in a compartment with a cut end of the sciatic nerve fibers, all of themn depressed the amplitude of the action potentials by similar potency, and these reductions significantly blocked by pretreatment of lower concentration $(10^{-10}\;M-10^{-8}M)$ of naloxone. These results support the previous findings by other workers that the stereospecific opioid receptors of this preparation are located on or near the intracellular opening of the sodium channels which are sensitive to naloxone.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  3. [국내논문]   Metabolism-Dependent Cavalent Binding of $S(-)-^3H-Nicotine$ to Lung Microsomes in Vitro  

    Kim, Bong-Hee (College of Pharmacy, Chung Nam National University ) , Shingenaga, Mark-K. (Department of Pharmacology and Division of Toxicology, University of Califonia)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.16 no.2 ,pp. 89 - 93 , 1993 , 0253-6269 ,

    초록

    Incubation of $S(-)-^3H$ -nicotine with rabbit lung microsomes in the presence of dioxygen and NADPH results in the formation of metabolities that bind covalently to microsomal macro-molecules. The addition of cytochrome P-450 monooxygenase inhibitors, $\alpha$ -methylbenzyl ami-nobenzotriazole and aroclor 1260, inhibited both (S)-nicotine metabolism and covalent binding. The relative rates of oxidation of nicotine $\Delta^{1',5'}$ iminium ion to continine indicates that lung $100,000\times{g}$ supematant catalyzed this oxidation approximately 18 times slower than that of liver system based on mg of protein, and increased covalent interactions. Since than that of liver system based on mg of protein, nd increased covalent interactions. Since the activity of lung iminium oxidase appears much lowr than the liver, it is tempting to speculate that localized concentrations of nicotine $\Delta^{1',5'}$ iminium ion in the lung will survive for a longer period of time. These results support that cytochrome P-450 catalyzed oxidation of nicotine leads to the formation of reactive nad electrophilic intemediates capable of chemical interactions with biomacromolecules.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  4. [국내논문]   Preparation of Azides from Hydrazines by using Dinitrogen Tetroxide as Nitrosonium Ion Source  

    Kim, Kweon (Department of Chemistry, Korea Advanced Institute of Science and Technology ) , Kim, Yong-Hae (Department of Chemistry, Korea Advanced Institute of Science and Technology)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.16 no.2 ,pp. 94 - 98 , 1993 , 0253-6269 ,

    초록

    Various hydrazines such as aryl-, carbonyl-, and sulfonyl-hydrazine were reacted with dinitrogen tetroxide to give the corresponding azides in excellent yields under mild ocnditions at low temperature $(-20-40^\circ{C)}$ in acetonitrile. The reaction appears to be initiated by formation of the .betha.-nitroso hydrazine intermediate which converts into the azide product.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  5. [국내논문]   Improved Phosphotyrosine Analysis by TLC and HPLC  

    Song, Young-Me (College of Pharmacy, Chonnam National University ) , Yoo, Gyurng-Soo (College of Pharmacy, Chonnam National University ) , Lee, Seung-Ki (College of Pharmacy, Seoul National University ) , Choi, Jung-Kap (College of Pharmacy, Chonnam National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.16 no.2 ,pp. 99 - 103 , 1993 , 0253-6269 ,

    초록

    We describe here the conditions of thin layer chromatography (TLC) and high pressures liquid chromatography (HPLC) to improve the analytical method of phosphotyrosine (p-Tyr) in biological sample. TLC was performed on silica plate with the mixture of propanol and water (2.1 : 1 v/v) as a mobile phase and $R_1$ values were 0.42, 0.39 and 0.33 for phosphotyrosine, phosphothreonine and phosphoserine, respectively. HPLC was performed on $NH_2$ column with a mobile phase of potassium biphosphate solution by UV deterction at 192 nm. The optimum condition of HPLC was obtained at 0.01 M, pH 4.5 with a clear separation within 12 min. These procedures have been applied to the analysis of phosphotyrosine obtained from tyrosine-phosphorylated enolase. Both TLC and HPLC methods were suitable to analyze tyrosine-phosphorylated protein without being affected by contaminants from hydrolysates.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  6. [국내논문]   Triterpenoid Saponins from the Root Barks of Aralia elata  

    Kang, Sam-Sik (Natural Products Research Institute, Seoul National University ) , Kim, Ju-Sun (Natural Products Research Institute, Seoul National University ) , Kim, Ok-Kyung (Natural Products Research Institute, Seoul National University ) , Lee, Eun-Bang (Natural Products Research Institute, Seoul National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.16 no.2 ,pp. 104 - 108 , 1993 , 0253-6269 ,

    초록

    From the root barks of Araila elata Seem.(Araliaceae) three known saponins together with oleanolic acid and $\beta$ -sitosterol $3-O-\beta$ -D-glucoside were isolated. The saponins were identified as oleanolic acid $28-O-\beta$ -D-glucoside were isolated. The saponins were identified as oleanolic acid $28-O-\beta$ -D-glucopyranosyl ester, oleanolic acid $3-O-\beta$ -D-glucuronopyranoside and oleanolic acid $3-O-\alpha$ -L-arabinofuranoysyl-(1 $\rightarrow$ 4)- $\beta$ -D-glucuronopyranoside(narcissiflo on the basis of chemical and spectra data. The latter two saponins were isolated as their dimethylesters as well as monomethylesters.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  7. [국내논문]   Triterpenoids from Rubi Fructus (Bogbunja)  

    Kim, Young Hee , Kang, Sam Sik
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.16 no.2 ,pp. 109 - 113 , 1993 , 0253-6269 ,

    초록

    From the root barks of Araila elata Seem.(Araliaceae) three known saponins together with oleanolic acid and $\beta$ -sitosterol $3-O-\beta$ -D-glucoside were isolated. The saponins were identified as oleanolic acid $28-O-\beta$ -D-glucoside were isolated. The saponins were identified as oleanolic acid $28-O-\beta$ -D-glucopyranosyl ester, oleanolic acid $3-O-\beta$ -D-glucuronopyranoside and oleanolic acid $3-O-\alpha$ -L-arabinofuranoysyl-(1 $\rightarrow$ 4)- $\beta$ -D-glucuronopyranoside(narcissiflo on the basis of chemical and spectra data. The latter two saponins were isolated as their dimethylesters as well as monomethylesters.

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    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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  8. [국내논문]   Triterpenoids from Rubi Fructus (Bogbumja)   피인용횟수: 2

    Kim, Young-Hee (College of Natural Sciences, Sangji University ) , Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.16 no.2 ,pp. 109 - 113 , 1993 , 0253-6269 ,

    초록

    The dried unnipe fruits of Rubus sp. (Rubi Fructus, Bogabunja) have yielded $\beta$ -sitosterol glucoside and four urs 12 en-28-oic acid derivatives, three of which were as their glucosiders. They were identified as 23-hydroxytomentic acid, rosamultin, niga-ichigosides $F_1\;and\;F_2$ on the basis of spectral data.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

    Fig. 1 이미지
  9. [국내논문]   Stimulatory Effect of Ginsenosides on $pp60^{c-src}$ Protein Tyrosine Kinase  

    Hong, Hee-Youn (College of Pharmacy, Chonnam National University ) , Park, Seon-Yang (College of Pharmacy, Chonnam National University ) , Lee, Seung-Ki (College of Pharmacy, Seoul National University ) , Yoo, Gyurng-Soo (College of Pharmacy, Chonnam National University ) , Choi, Jung-Kap (College of Pharmacy, Chonnam National University)
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.16 no.2 ,pp. 114 - 117 , 1993 , 0253-6269 ,

    초록

    Ginsenosides present in the roots of panax ginseng C.A. Meyer were shown to induce a stimulatory effect on the overexpressed cellular chicken c-src protein tyrossine kinase in NH3T3 cells. Among 4 ginsenosides studied $(G-Rb_2,\;G-Rc,\;G-Re\;and\;G-Rg_1),\;G-Rg_1$ showed the most stimulatory effect at $16.7\mu{g/ml}$ ginsenoside concentration increasing the activity by 2-4 times. Inhibitors of either protein synthesis or RNA synthesis blocked the activation of c-src proein tyrosine kinase. These results suggest that the csrc kinase activation apprars to involve an increase in the amount of protein of the kinase by transcriptional control mechanism rather than an increase in the kinase activity.

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    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

    이미지

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  10. [국내논문]   Effects of n-alkanols on the rotational relaxation time of 1,6-Diphenyl-1,3,5-hexatriene in the synaptosomal plasma membrane vesicles isolated from bovine cerebral cortex  

    Chung, Yong-Za , Cho, Goon-Jae , Yun, Il
    Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea v.16 no.2 ,pp. 118 - 122 , 1993 , 0253-6269 ,

    초록

    Ginsenosides present in the roots of panax ginseng C.A. Meyer were shown to induce a stimulatory effect on the overexpressed cellular chicken c-src protein tyrossine kinase in NH3T3 cells. Among 4 ginsenosides studied $(G-Rb_2,\;G-Rc,\;G-Re\;and\;G-Rg_1),\;G-Rg_1$ showed the most stimulatory effect at $16.7\mu{g/ml}$ ginsenoside concentration increasing the activity by 2-4 times. Inhibitors of either protein synthesis or RNA synthesis blocked the activation of c-src proein tyrosine kinase. These results suggest that the csrc kinase activation apprars to involve an increase in the amount of protein of the kinase by transcriptional control mechanism rather than an increase in the kinase activity.

    원문보기

    원문보기
    무료다운로드 유료다운로드

    회원님의 원문열람 권한에 따라 열람이 불가능 할 수 있으며 권한이 없는 경우 해당 사이트의 정책에 따라 회원가입 및 유료구매가 필요할 수 있습니다.이동하는 사이트에서의 모든 정보이용은 NDSL과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니담기를 통하여 원문복사서비스 이용이 가능합니다.

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